1. Articles from sandeep grover

    1-18 of 18
    1. The application of optical coherence tomography angiography in retinal diseases

      The application of optical coherence tomography angiography in retinal diseases

      Optical coherence tomography angiography (OCTA) is a new, noninvasive imaging technique that generates real-time volumetric data on chorioretinal vasculature and its flow pattern. With the advent of high-speed optical coherence tomography, established en face chorioretinal segmentation, and efficient algorithms, OCTA generates images that resemble an angiogram. The principle of OCTA involves determining the change in backscattering between consecutive B-scans and then attributing the differences to the flow of erythrocytes through retinal blood vessels . OCTA has shown promise in the evaluation of common ophthalmologic diseases such as diabetic retinopathy , age-related macular degeneration , and retinal vascular occlusions . It quantifies vascular compromise reflecting ...

      Read Full Article
    2. TEMPORAL THINNING IN SICKLE CELL RETINOPATHY IS ASSOCIATED WITH DIMINISHED PERFUSION ON OCTA AND DENSE SCOTOMA ON MICROPERIMETERY

      TEMPORAL THINNING IN SICKLE CELL RETINOPATHY IS ASSOCIATED WITH DIMINISHED PERFUSION ON OCTA AND DENSE SCOTOMA ON MICROPERIMETERY

      Purpose: To establish correlation between the structural compromise (capillary loss and hypoperfusion on optical coherence tomography [optical coherence tomography angiography]) with perimacular functional impairment noted on microperimetry. Methods: Retrospective case series. Clinical records and multimodal imaging findings of patients presenting with sickle cell disease were reviewed. Results: Three eyes of three patients (two men) were included in the study with a visual acuity of 20/20 and no sickle cell retinopathy. Images using optical coherence tomography angiography (AngioVue OCT angiography system; Optovue, Inc, Fremont, CA) were obtained along with spectral domain optical coherence tomography, fluorescein angiography, and microperimetry (MP-1). Spectral ...

      Read Full Article
    3. The Application of Optical Coherence Tomography Angiography in Retinal Diseases

      The Application of Optical Coherence Tomography Angiography in Retinal Diseases

      Optical coherence tomography angiography (OCTA) is a new, non-invasive imaging technique that generates real time volumetric data of chorioretinal vasculature and its flow pattern. With the advent of high-speed optical coherence tomography, established en-face chorioretinal segmentation, and efficient algorithms, OCTA generate images that resembles an angiogram. The principle of OCTA involves determining the change in backscattering between consecutive B-scans and then attributing the differences to the flow of erythrocytes through retinal blood vessels. OCTA has shown promise in the evaluation of common ophthalmologic diseases such as diabetic retinopathy, age- related macular degeneration (AMD) and retinal vascular occlusions. It quantifies vascular ...

      Read Full Article
    4. SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY VALIDATES LAMINA CRIBROSA ANOMALY IN OPTIC DISK PIT

      SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY VALIDATES LAMINA CRIBROSA ANOMALY IN OPTIC DISK PIT

      Purpose: Swept Source Optical Coherence Tomography validates lamina cribrosa anomaly in optic disk pit. Method: Observational case report. Results: A 25-year-old African American male presented with decreased vision in right eye of 4 days duration. Best corrected visual acuity (BCVA) for distance in right eye was 20/200 and in left eye was 20/20. Dilated fundus examination of right eye showed serous macular detachment of entire posterior pole along with an optic pit on temporal margin of optic disk. En-face image of the optic disk on Swept source OCT (SS-OCT) confirmed defect in the lamina cribrosa in the right ...

      Read Full Article
    5. Clinical applications of spectral domain optical coherence tomography in retinal diseases

      Clinical applications of spectral domain optical coherence tomography in retinal diseases

      Optical coherence tomography (OCT) was introduced about two decades ago and has revolutionized ophthalmic practice in recent years. It is a noninvasive noncontact imaging modality that provides a high-resolution cross-sectional image of the cornea, retina, choroid and optic nerve head, analogous to that of the histological section. Advances in OCT technology in signal detection technique from time-domain (TD) to spectral-domain (SD) detection have given us the potential to study various retinal layers more precisely and in less time. SD-OCT better delineates structural changes and fine lesions in the individual retinal layers. Thus, we have gained substantial information about the pathologic ...

      Read Full Article
    6. Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan

      Comparison of central corneal thickness: ultrasound pachymetry versus slit-lamp optical coherence tomography, specular microscopy, and Orbscan

      Background: Central corneal thickness (CCT) can be measured by using contact and non-contact methods. Ultrasound pachymetry (US pachymetry) is a contact method for measuring CCT and is perhaps the most commonly used method. However, non-contact methods like scanning slit topography (Orbscan II), slit-lamp optical coherence tomography (SL-OCT), and specular microscopy are also used. Not many studies have correlated the measurement of CCT with all four modalities. The purpose of this study was to compare and correlate the CCT measurements obtained by US pachymetry with SL-OCT, specular microscopy, and Orbscan. Method: This is a prospective, comparative study done in an institutional ...

      Read Full Article
    7. Retinal Thickness Measurement Obtained with Spectral Domain Optical Coherence Tomography Assisted Optical Biopsy Accurately Correlates with Ex Vivo Histology

      Retinal Thickness Measurement Obtained with Spectral Domain Optical Coherence Tomography Assisted Optical Biopsy Accurately Correlates with Ex Vivo Histology

      Background This study determines ‘correlation constants’ between the gold standard histological measurement of retinal thickness and the newer spectral-domain optical coherence tomography (SD-OCT) technology in adult C57BL/6 mice. Methods Forty-eight eyes from adult mice underwent SD-OCT imaging and then were histologically prepared for frozen sectioning with H&E staining. Retinal thickness was measured via 10x light microscopy. SD-OCT images and histological sections were standardized to three anatomical sites relative to the optic nerve head (ONH) location. The ratios between SD-OCT to histological thickness for total retinal thickness (TRT) and six sublayers were defined as ‘correlation constants’. Results Mean (± SE ...

      Read Full Article
    8. Retinal Thickness in People with Diabetes and Minimal or No Diabetic Retinopathy: Heidelberg Spectralis Optical Coherence Tomography

      Retinal Thickness in People with Diabetes and Minimal or No Diabetic Retinopathy: Heidelberg Spectralis Optical Coherence Tomography

      Purpose: To evaluate macular thickness in people with diabetes but minimal or no retinopathy using Heidelberg Spectralis optical coherence tomography (OCT). Methods: In a multi-center, cross-sectional study of mean retinal thickness, on Spectralis OCT in the 9 standard OCT subfields, spanning a zone with 6 mm diameter, center point, and total retinal volume were evaluated. Central subfield (CSF) thickness was evaluated for association with demographic and clinical factors. Stratus OCT scans also were performed on each participant. Results: The analysis included 122 eyes (122 participants) with diabetes and no (N = 103) or minimal diabetic retinopathy (N = 19) and no macular ...

      Read Full Article
    9. Modified protocol for in vivo imaging of wild-type mouse retina with customized miniature spectral domain optical coherence tomography (SD-OCT) device

      Modified protocol for in vivo imaging of wild-type mouse retina with customized miniature spectral domain optical coherence tomography (SD-OCT) device

      This protocol outlines and evaluates a modified scanning procedure for a customized spectral domain optical coherence tomography (SD-OCT) imaging apparatus within the wild-type C57Bl/6 mouse posterior segment. This modified protocol allows for the capture of a 50 degree field of view spanning 3 mm by 3 mm perimeter with the optic disc as the central point. By utilizing this scanning protocol a more reliable measurement of retinal thickness can be achieved outside the fluctuating region of the optic disc. This protocol, when applied to this high resolution device, enables non-invasive in vivo histological imaging and biometric assessment of the ...

      Read Full Article
    10. Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report

      Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report
      Introduction Spectral-domain optical coherence tomography findings in a patient with acute macular neuroretinopathy, and correlation with functional defects on microperimetry, are presented. Case presentation A 25-year old Caucasian woman presented with bitemporal field defects following an upper respiratory tract infection. Her visual acuity was 20/20 in both eyes and a dilated fundus examination revealed bilateral hyperpigmentary changes in the papillomacular bundle. Our patient underwent further evaluation with spectral-domain optical coherence tomography, infrared and fundus autofluorescence imaging. Functional changes were assessed by microperimetry. Infrared imaging showed the classic wedge-shaped defects and spectral-domain optical coherence tomography exhibited changes at the inner ...
      Read Full Article
    11. Infrared imaging and spectral-domain optical coherence tomography

      Infrared imaging and spectral-domain optical coherence tomography

      Introduction Spectral-domain optical coherence tomography findings in a patient with acute macular neuroretinopathy, and correlation with functional defects on microperimetry, are presented. Case presentation A 25-year old Caucasian woman presented with bitemporal field defects following an upper respiratory tract infection. Her visual acuity was 20/20 in both eyes and a dilated fundus examination revealed bilateral hyperpigmentary changes in the papillomacular bundle. Our patient underwent further evaluation with spectral-domain optical coherence tomography, infrared and fundus autofluorescence imaging. Functional changes were assessed by microperimetry. Infrared imaging showed the classic wedge-shaped defects and spectral-domain optical coherence tomography exhibited changes at the inner ...

      Read Full Article
    12. Temporal Macular Thinning on Spectral-Domain Optical Coherence Tomography in Proliferative Sickle Cell Retinopathy

      Temporal Macular Thinning on Spectral-Domain Optical Coherence Tomography in Proliferative Sickle Cell Retinopathy
      Sickle cell retinopathy is associated with retinal ischemia due to sickling of red blood cells in retinal arterioles that supply nutrients to the inner retinal layers.1-2 Proliferative sickle cell retinopathy (PSR) results in neovascularization caused by occlusion of the peripheral arteriole, typically at the branching points of the arterioles.3 Although neovascularization may be seen at the optic disc and the macula, PSR is primarily a peripheral ischemic retinal disease that results in vitreous hemorrhage and retinal detachment.1 However, peripheral ischemia can easily be missed on clinical examination, and invasive techniques such as wide-field angiography are required to ...
      Read Full Article
    13. In-vivo high resolution imaging of optic nerve head drusen using spectral-domain Optical Coherence Tomography

      In-vivo high resolution imaging of optic nerve head drusen using spectral-domain Optical Coherence Tomography
      Background Optic nerve head drusen (ONHD) are white calcareous deposits, seen either superficially on the optic nerve head or buried within it. Diagnosis of ONHD is made by one or more ways: clinical exam, autofluorescence, ultrasound of the optic nerve, CT scan and/or visual field examination. The present study describes features of ONHD based on another diagnostic modality, the spectral-domain OCT (Spectralis). Methods This is an observational case series of 5 patients with bilateral ONHD with a best-corrected visual acuity of 20/20 and no other posterior segment pathology. All the patients underwent fundus photography, fundus autofluorescence, B-scan ultrasonography ...
      Read Full Article
    14. Comparison of Retinal Thickness in Normal Eyes Using Stratus and Spectralis Optical Coherence Tomography

      Comparison of Retinal Thickness in Normal Eyes Using Stratus and Spectralis Optical Coherence Tomography
      Purpose. Spectral-domain optical coherence tomography (SD-OCT) is an advancement over time-domain OCT (TD-OCT) in the imaging of retinal disorders. Retinal thickness measured by SD-OCT differs from that measured by TD-OCT because the delineation of the outer boundary of the retina differs in the two instruments. The present study aims to evaluate this difference by comparing macular thickness, as obtained by Stratus and Spectralis OCT, in subjects without any known retinal disease. Methods. Thirty-six subjects with no history of retinal disease and with normal vision and normal intraocular pressure were enrolled in the study. Both Stratus and Spectralis OCT scanning were ...
      Read Full Article
    15. Foveal structure defined by spectral domain optical coherence tomography correlates with visual function after macular hole surgery

      Purpose. To study the correlation between final visual acuity after successful anatomic macular hole repair and features on spectral domain optical coherence tomography (SD-OCT). Methods. Retrospective review of charts of patients who underwent macular hole surgery. Data collection included pre- and postoperative best-corrected visual acuity (BCVA), central subfield foveal thickness (CSFT), and presence or absence of inner segment–outer segment (IS-OS) line changes on SD-OCT. Data collected from SD-OCT were correlated with Snellen BCVA, which was converted to logMAR score. Subjects were divided into 2 groups: group I had improvement in BCVA of 2 lines or more and group II ...
      Read Full Article
    16. Comparison of retinal thickness in normal eyes using Stratus and Spectralis Optical Coherence Tomography

      Purpose: Spectral-domain OCT (SD-OCT) is an advancement over time-domain OCT (TD-OCT) in the imaging of retinal disorders. The retinal thickness, as measured by SD-OCT (Spectralis) differs from that by TD-OCT (Stratus) as the delineation of outer boundary of the retina differs in the two instruments. The present study aims to evaluate this difference by comparing the macular thickness, as obtained by Stratus and Spectralis OCT in subjects without any known retinal disease. Methods: Thirty-six subjects with no history of any prior retinal disease, normal vision and intraocular pressure were enrolled in the study. Both Stratus and Spectralis OCT scanning were ...
      Read Full Article
    17. Normative Data for Macular Thickness by High-Definition Spectral-Domain Optical Coherence Tomography (Spectralis)

      Purpose To establish normative data for the macular thickness by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease. Design Prospective, observational study in an academic institutional setting. Methods Fifty subjects (age range, 20 to 84 years) with no known retinal disease, best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. The subjects were divided into 3 age groups: group 1 included subjects 20 to 40 years of age; group 2 included subjects 41 to 60 years of age; and group 3 included subjects 61 years of age and older. All subjects underwent a complete ...
      Read Full Article
    18. Rebound Of Cystoid Macular Edema With Continued Use Of Acetazolamide In Patients With Retinitis Pigmentosa.

      Optical coherence tomography is more sensitive than fluorescein angiography for the detection and monitoring of cystoid macular edema during treatment with acetazolamide in patients with retinitis pigmentosa.Page: 1112DOI: 10.1097/IAE.0b013e31805f6b79Authors: APUSHKIN, MARSHA A. MD; FISHMAN, GERALD A. MD; GROVER, SANDEEP MD; JANOWICZ, MARK J. BA
      Read Full Article
    1-18 of 18
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (18 articles) Sandeep Grover
    2. (17 articles) University of Florida
    3. (17 articles) Kakarla V. Chalam
    4. (8 articles) Ravi K. Murthy
    5. (7 articles) Heidelberg Engineering
    6. (6 articles) Heidelberg Spectralis
    7. (3 articles) Zeiss Stratus OCT
    8. (2 articles) Carl Zeiss Meditec
    9. (1 articles) Johns Hopkins University
    10. (1 articles) Leica
    11. (1 articles) FDA
    12. (1 articles) Harvard University
    13. (1 articles) Massachusetts General Hospital
    14. (1 articles) Guillermo J. Tearney
    15. (1 articles) Brian K. Courtney
    16. (1 articles) Conavi Medical Inc.
  3. Popular Articles

  4. Picture Gallery

    Comparison of Retinal Thickness in Normal Eyes Using Stratus and Spectralis Optical Coherence Tomography In-vivo high resolution imaging of optic nerve head drusen using spectral-domain Optical Coherence Tomography Temporal Macular Thinning on Spectral-Domain Optical Coherence Tomography in Proliferative Sickle Cell Retinopathy Infrared imaging and spectral-domain optical coherence tomography findings correlate with microperimetry in acute macular neuroretinopathy: a case report Modified protocol for in vivo imaging of wild-type mouse retina with customized miniature spectral domain optical coherence tomography (SD-OCT) device Retinal Thickness in People with Diabetes and Minimal or No Diabetic Retinopathy: Heidelberg Spectralis Optical Coherence Tomography Conavi Medical and Japan Lifeline Announce MHLW Approval of Novasight Hybrid Intravascular Imaging System for Japanese Market Capsule Endomicroscopy for Visualization of the Small Intestine in EED Population in Pakistan Three-dimensional detection and quantification of defects in SiC by optical coherence tomography University of Illinois at Chicago Receives NIH Grant for Functional Tomography of Neurovascular Coupling Interactions in Healthy and Diseased Retinas Dyad Medical Receives NIH Grant for Software For OCT Analysis of Vascular Stents Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases