1. Articles from donna m. hutchison

    1-7 of 7
    1. Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects

      Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects

      Background/aims Quantitative analysis of optical coherence tomography angiography (OCT-A) images requires a reproducible approach that accounts for sectoral loss. The objective of this study was to determine whether an index that accounts for both global (perfusion density, PD) and asymmetric loss of perfusion, rather than PD alone, more reliably measures loss of perfusion in patients with glaucoma. Methods We analysed macular OCT-A scans of 95 glaucoma patients and 59 control subjects. Two-dimensional projection images corresponding to the superficial vascular plexus were exported and analyses performed to calculate global PD and image asymmetry. An unsigned perfusion asymmetry index (PAI) that ...

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    2. Influence of Bruch’s Membrane Opening Area in Diagnosing Glaucoma with Neuroretinal Parameters from Optical Coherence Tomography

      Influence of Bruch’s Membrane Opening Area in Diagnosing Glaucoma with Neuroretinal Parameters from Optical Coherence Tomography

      Purpose To determine whether the glaucoma diagnostic accuracy of age and Bruch’s membrane opening area (BMOA) adjusted normative classifications of minimum rim width (MRW) and retinal nerve fibre layer thickness (RNFLT) is dependent on BMOA, in a European descent population. Design Retrospective, cross-sectional study. Methods We included 182 glaucoma patients and 166 healthy controls for the primary study, and 105 glaucoma patients in a second sample used for a replication study. Optical coherence tomography (Spectralis) measurements of BMOA, global MRW and RNFLT and normative classifications from the device software were exported for analysis. Sensitivity and specificity were calculated for ...

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    3. Imaging of the Temporal Raphe with Optical Coherence Tomography

      Imaging of the Temporal Raphe with Optical Coherence Tomography

      There has been considerable debate about the arrangement and composition of the temporal raphe in the human retina. In postmortem studies, Vrabec 1 showed that axons of retinal ganglion cells temporal to the fovea are forced to take an arched course above and below the papillomacular bundle and that the temporal raphe generally represents a watershed midline. However, there is scarce published literature on the relationship between the orientation of the papillomacular bundle and the temporal raphe.

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    4. Automated Segmentation of Optic Nerve Head Structures with Optical Coherence Tomography

      Automated Segmentation of Optic Nerve Head Structures with Optical Coherence Tomography

      Purpose: To quantify and characterise the difference between automated and manual segmentation of optic nerve head structures with spectral domain-optical coherence tomography (SD-OCT). Methods: Optic nerve head radial scans in 107 glaucoma patients and 48 healthy controls were conducted with SD-OCT. Independent segmentations of the internal limiting membrane (ILM) and Bruch's membrane opening (BMO) were performed manually with custom software and with an automated algorithm in each radial scan. The minimum distance between BMO and ILM, termed BMO-minimum rim width (BMO-MRW) was calculated with each segmentation method. Absolute differences between automated and manual segmentations of ILM (ΔILM) and BMO ...

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    5. Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter

      Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter

      Objective Neuroretinal rim assessment based on the clinical optic disc margin (DM) lacks a sound anatomic basis for 2 reasons: (1) The DM is not reliable as the outer border of rim tissue because of clinically and photographically invisible extensions of Bruch's membrane (BM) inside the DM and (2) nonaccountability of rim tissue orientation in the optic nerve head (ONH). The BM opening-minimum rim width (BMO-MRW) is a parameter that quantifies the rim from its true anatomic outer border, BMO, and accounts for its variable orientation. We report the diagnostic capability of BMO-MRW. Design Case control. Participants Patients with ...

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    6. Comparison between confocal scanning laser tomography, scanning laser polarimetry and optical coherence tomography on the ability to detect localized retinal nerve fiber layer defects in glaucoma patients

      Background/Aim: To compare the ability of confocal scanning laser tomography (CSLT), scanning laser polarimetry (SLP) and optical coherence tomography (OCT) in recognizing localized retinal nerve fiber layer (RNFL) defects. Methods: 51 eyes from 43 patients with glaucoma were identified by two observers as having RNFL defects visible on optic disc photographs. 51 eyes of 32 normal subjects were used as controls. Three masked observers evaluated CSLT, SLP and OCT images to determine subjectively the presence of localized RNFL defects. Results: Interobserver agreement was highest with OCT, followed by SLP and CSLT (mean kappa: 0.83, 0.69 and 0 ...

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    1-7 of 7
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    Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography–Derived Neuroretinal Rim Parameter Automated Segmentation of Optic Nerve Head Structures with Optical Coherence Tomography Imaging of the Temporal Raphe with Optical Coherence Tomography Influence of Bruch’s Membrane Opening Area in Diagnosing Glaucoma with Neuroretinal Parameters from Optical Coherence Tomography Asymmetry analysis of macular optical coherence tomography angiography in patients with glaucoma and healthy subjects Peripapillary Retinal Segmentation in Optical Coherence Tomography Angiography Optical coherence tomography features of neovascularization in proliferative diabetic retinopathy: a systematic review Retinal microvascular metrics in untreated essential hypertensives using optical coherence tomography angiography Optical coherence tomography angiography findings of fellow eye of proliferative macular telangiectasia type 2: Long term study Reorganization of the perifoveal microvasculature after macular hole closure assessed via optical coherence tomography angiography Optical coherence tomography angiography (OCTA) findings in Serpiginous Choroiditis Changes in retinal layer thickness with maturation in the dog: an in vivo spectral domain - optical coherence tomography imaging study