1. Articles from Hai Sun

    1-3 of 3
    1. Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography

      Volumetric in-vivo imaging of intra-cochlear microstructures and microvascular perfusion in mice using high-speed spectral domain optical coherence tomography and ultra-high sensitive optical microangiography

      Studying the inner ear microstructures and microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention and treatment of many otologic disorders. There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea and the micro vascular perfusion within it for both clinical as well as fundamental studies. In this study, we explored the feasibility of high-speed spectral domain optical coherence tomography (SD-OCT) and ultra-high sensitive optical microangiography (UHS-OMAG) for volumetric in vivo imaging of intracochlear microstructures and microvascular perfusion in mice, respectively.

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    2. Volumetric In Vivo Imaging of Microvascular Perfusion Within the Intact Cochlea in Mice Using Ultra-High Sensitive Optical Microangiography

      Volumetric In Vivo Imaging of Microvascular Perfusion Within the Intact Cochlea in Mice Using Ultra-High Sensitive Optical Microangiography
      Studying the inner ear microvascular dynamics is extremely important to understand the cochlear function and to further advance the diagnosis, prevention, and treatment of many otologic disorders. However, there is currently no effective imaging tool available that is able to access the blood flow within the intact cochlea. In this paper, we report the use of an ultrahigh sensitive optical micro-angiography (UHS-OMAG) imaging system to image 3-D microvascular perfusion within the intact cochlea in living mice. The UHS-OMAG image system used in this study is based on spectral domain optical coherence tomography, which uses a broadband light source centered at ...
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    3. Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography

      Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography
      There is considerable interest in developing new methods for in vivo imaging of the complex anatomy of the mammalian cochlea for clinical as well as fundamental studies. In this study, we explored, the feasibility of spectral domain optical coherence tomography (SD-OCT) for 3-D in vivo imaging of the cochlea in mice. The SD-OCT system employed in this study used a broadband light source centered at 1300 nm, and the imaging speed of the system was 47,000 A-scans per second using the InGaAs camera. The system was capable of providing fully processed, high-resolution B-scan images [512 (axial)×128 (lateral) pixels ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Oregon Health & Science University
    2. (3 articles) Ruikang K. Wang
    3. (3 articles) Viviana Davila
    4. (3 articles) Hai Sun
    5. (3 articles) Alfred L. Nuttall
    6. (3 articles) Anh T. Nguyen-Huynh
    7. (3 articles) Hrebesh M. Subhash
    8. (2 articles) Massachusetts General Hospital
    9. (1 articles) University of Washington
    10. (1 articles) Harvard University
    11. (1 articles) The Chinese University of Hong Kong
    12. (1 articles) University of Miami
    13. (1 articles) VU University Amsterdam
    14. (1 articles) David A. Boas
    15. (1 articles) Brett E. Bouma
    16. (1 articles) Johannes F. de Boer
    17. (1 articles) Frank D. Verbraak
    18. (1 articles) Apollo Medical Optics
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