1. Articles from atsushi sakamoto

    1-16 of 16
    1. Detection of Cholesterol Crystals by Optical Coherence Tomography

      Detection of Cholesterol Crystals by Optical Coherence Tomography

      Aim: To determine the ability of optical frequency domain imaging (OFDI)/optical coherence tomography (OCT) imaging systems to visualize presence of cholesterol crystals (CCR) in human atherosclerotic coronary arteries. Methods and Results: We performed ex vivo imaging by OFDI/OCT of human coronary arteries. A total of 559 cross-sectional images from 45 autopsy cases were co-registered with histology and 117 histologic sections showed presence of necrotic core with cholesterol clefts (CC). We modified a previously used OFDI/OCT definition for identification of CCRs which we now define as a linear and discreet high intensity signal (bright area) within the plaque ...

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    2. Automated Assessment of Drusen Using Three-dimensional Spectral-domain Optical Coherence Tomography

      Automated Assessment of Drusen Using Three-dimensional Spectral-domain Optical Coherence Tomography

      Purpose: To compare automated assessment of macular drusen delineated by our originally-developed algorithm on 3-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) with the assessment by certificated graders on color fundus photographs in non-neovascular age-related macular degeneration (AMD). Design: Prospective case series. Methods: Automated assessment of macular drusen was performed using raster scan by 3D OCT-1000 (Topcon) in 18 eyes with non-neovascular AMD with at least one large druse (≥125μm) and predominantly soft indistinct drusen. We defined drusen as the regions that have the distance between the RPE and calculated Bruch's membrane lines > predefined threshold distances. We assessed the agreement ...

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    3. Characteristics of Optical Coherence Tomographic Hyperreflective Foci in Retinal Vein Occlusion

      Characteristics of Optical Coherence Tomographic Hyperreflective Foci in Retinal Vein Occlusion
      Purpose: To evaluate the hyperreflective foci in branch retinal vein occlusion and central retinal vein occlusion depicted by spectral-domain optical coherence tomography (OCT). Methods: Consecutive series of 73 eyes of 73 patients with retinal vein occlusion (58 branch retinal vein occlusion and 15 central retinal vein occlusion) who had Spectralis OCT images obtained were retrospectively reviewed, comparing color fundus photographs and fluorescein angiography. Results: Hyperreflective foci were detected in 54 eyes (74.0%) by spectral-domain OCT, and hard exudates were detected in 17 eyes (23.3%) by color fundus photography. Hard exudates on the color photographs corresponded to the confluence ...
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    4. High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy

      High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy
      Objective: To compare, in eyes with an idiopathic epiretinal membrane (ERM), photoreceptor cell structural abnormalities identified on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO-SLO) with the severity of metamorphopsia and anatomic findings on spectral-domain optical coherence tomography (SD-OCT). Design: Observational case series. Participants: Twenty-five eyes of 24 patients with idiopathic ERM and 20 normal eyes of 20 volunteer subjects. Methods: All participants underwent a full ophthalmologic examination, SD-OCT, and imaging with an original prototype AO-SLO system that incorporated liquid crystal-on-silicon technology. In eyes with ERM, M-CHARTS results were used to quantify metamorphopsia. Main Outcome Measures: Cone mosaic ...
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    5. Optical Coherence Tomographic Characteristics of Microaneurysms in Diabetic Retinopathy

      Optical Coherence Tomographic Characteristics of Microaneurysms in Diabetic Retinopathy
      Purpose: To characterize microaneurysms in diabetic retinopathy (DR) depicted by spectral-domain optical coherence tomography (SD-OCT).Design: Retrospective, observational case series.Methods: We surveyed a consecutive series of 76 eyes from 60 patients with DR (22 mild nonproliferative diabetic retinopathy [NPDR]; 43 moderate NPDR; 9 severe NPDR; 2 proliferative diabetic retinopathy [PDR]) who underwent Spectralis OCT, fluorescein angiography (FA), and color fundus photography on the same day. The microaneurysms on OCT were oval and well demarcated at the points where those on color fundus photographs and FA were delineated. The characteristics of microaneurysms were evaluated.Results: Based on the status of ...
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    6. Optical Coherence Tomographic Evaluation of Foveal Hard Exudates in Patients with Diabetic Maculopathy Accompanying Macular Detachment

      Optical Coherence Tomographic Evaluation of Foveal Hard Exudates in Patients with Diabetic Maculopathy Accompanying Macular Detachment
      Objective:: To study morphologic changes of serous retinal detachment (SRD) and hyperreflective dots, which have been reported to be precursors of hard exudates, detectable in SRD using optical coherence tomography (OCT) to assess whether or not the OCT findings are correlated with the subfoveal deposition of hard exudates in patients with diabetic macular edema (DME) accompanied by SRD.Design:: Retrospective chart review.Participants:: Twenty-eight eyes of 19 patients with DME accompanied by SRD.Methods:: We imaged SRD and the hyperreflective dots in SRD using spectral domain OCT (SD-OCT). The number and distribution of the hyperreflective dots in SRD were evaluated ...
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    7. High-Resolution Imaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy

      High-Resolution Imaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy

      Objective To compare pathologic changes in photoreceptors in eyes with resolved central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT). Design Observational case series. Participants Forty-five eyes of 38 patients with resolved CSC and 20 normal eyes of 20 volunteer subjects. Methods All patients underwent a full ophthalmologic examination, SD OCT, and imaging with an original prototype AO SLO system fabricated using liquid crystal-on-silicon technology. Main Outcome Measures Cone mosaic patterns and cone density on AO SLO images and ...

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    8. Three-Dimensional Imaging of Macular Retinal Nerve Fiber Layer in Glaucoma Using Spectral-Domain Optical Coherence Tomography

      Three-Dimensional Imaging of Macular Retinal Nerve Fiber Layer in Glaucoma Using Spectral-Domain Optical Coherence Tomography
      Purpose: To investigate the three-dimensional (3D), spectral-domain (SD) optical coherence tomography (3D,SD-OCT) imaging of the macular retinal nerve fiber layer (RNFL) in eyes with glaucoma. Methods: We studied 38 eyes of 38 patients with glaucoma and 38 normal eyes of 38 volunteers. Using a 3D raster scan protocol, 512 x 128 axial scans were acquired over a 6 mm x 6 mm square area of the macula using SD-OCT. Findings on 3D,SD-OCT images were compared with those on color and red-free fundus photographs and time-domain (TD) OCT. Results: Fourteen (30.4%) more RNFL defects were detected on 3D ...
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    9. Spectral-domain Optical Coherence Tomography Measurement of Macular Volume for Diagnosing Glaucoma

      Purpose: To determine the glaucoma diagnostic power of measuring the volume of the ganglion cell complex (GCC; 3 innermost retinal layers) using spectral-domain optical coherence tomography (SD-OCT). Patients and Methods: Fifty eyes with open-angle glaucoma and 35 normal partipants were included for this study. SD-OCT (RTVue-100), and time-domain (TD)-OCT were used to measure total retinal, GCC (SD-OCT only), and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses in 50 eyes with open-angle glaucoma and in 35 without glaucoma. Results: Total retinal and GCC volumes in a macular area correlated with visual field mean deviation (GCC: r=0.580, P<0 ...
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    10. Three-dimensional Profile of Macular Retinal Thickness in Normal Japanese Eyes

      Purpose: To demonstrate the 3-dimensional macular thickness distribution in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate its association with sex, age, and axial length. Methods: Mean regional retinal thickness measurements on the Early Treatment Diabetic Retinopathy Study (ETDRS) layout were obtained by 3-dimensional raster scanning (6 X 6 mm) using SD-OCT in 248 normal eyes of 248 Japanese subjects. Results: Mean foveal thickness was 222 ± 19 µm; it was significantly greater in men (226 ± 19 µm) than in women (218 ± 18 µm; P = 0.002) and did not correlate with age in either sex. Mean sectorial ...
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    11. Retinal Structural Changes Associated With Retinal Arterial Macroaneurysm Examined With Optical Coherence Tomography.

      Retinal arterial macroaneurysm can cause hemorrhagic and/or exudative complications. Eyes with minimal hemorrhage from the aneurysm often showed an extensive exudative change that extended to the fovea. In these eyes, retinal edema was seen predominantly in the outer nuclear layer, accompanying a focal serous retinal detachment beneath the fovea.Page: 782DOI: 10.1097/IAE.0b013e3181a2f26aAuthors: TSUJIKAWA, AKITAKA MD; SAKAMOTO, ATSUSHI MD; OTA, MASAFUMI MD; OH, HIDEYASU MD; MIYAMOTO, KAZUAKI MD; KITA, MIHORI MD; YOSHIMURA, NAGAHISA MD
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    12. Evaluation of potential visual acuity in eyes with macular oedema secondary to retinal vein occlusion

      Purpose: To evaluate the potential visual acuity (VA) of eyes with macular oedema (MO) associated with retinal vein occlusion (RVO). Methods: Thirty-one eyes of 31 patients with MO associated with RVO were examined and then treated with an intravitreal injection of bevacizumab. Of these 31 eyes, 22 showed complete resolution of the MO at 1 month after treatment, at which time potential VA was determined; 12 eyes had good function and 10 had poor function at this time. Optical coherence tomography was used to detect the junctions between inner and outer segments of the photoreceptors (IS/OS) as a hallmark ...
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    13. Ultrahigh-resolution versus speckle noise-reduction in spectral-domain optical coherence tomography

      Ultrahigh-resolution versus speckle noise-reduction in spectral-domain optical coherence tomography
      Ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) and speckle noise-reduced SD-OCT instruments were compared with regard to their ability to visualize retinal microstructures and detect micropathologies in the same series of eyes in this hospital-based study. Both the instruments identically visualized normal retinal structures, except for the retinal ganglion cell layer, which was better delineated by the speckle noise-reduced SD-OCT instrument. Retinal pigment epithelium (RPE) and Bruch’s membrane were better delineated by UHR SD-OCT. Retinal and sub-RPE pathologies were also identically visualized by both the instruments. Layer differentiation for locating each pathology was better visualized by speckle noise-reduced SD-OCT.
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    14. IMPROVED VISUALIZATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY LESIONS USING SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY.

      Purpose: To report the tomographic features of vascular lesions beneath the retinal pigment epithelium in eyes with polypoidal choroidal vasculopathy by using spectral-domain optical coherence tomography (SD-OCT). Design: Retrospective observational case series. Methods: Angiograms and images obtained using the prototype SD-OCT system were compared for 21 eyes of 21 patients with polypoidal choroidal vasculopathy to identify sub-retinal pigment epithelium abnormalities visible on three-dimensional and enhanced SD-OCT images. Results: On angiography, a branching vascular network and at least 1 polypoidal lesion were visible in all 21 eyes; 10 eyes also had pigment epithelial detachment (PED). SD-OCT revealed a thin straight line ...
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    15. SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING OF THE DETACHED MACULA IN RHEGMATOGENOUS RETINAL DETACHMENT

      Purpose: To assess detached macula in rhegmatogenous retinal detachment by using spectral-domain optical coherence tomography. Methods: This retrospective study included 15 eyes of 15 patients with macula-off rhegmatogenous retinal detachment and 16 eyes of 16 patients with acute central serous chorioretinopathy. These patients were examined with a prototype spectral-domain optical coherence tomography system. Results: Spectral-domain optical coherence tomography of eyes with rhegmatogenous retinal detachment revealed macular structural abnormalities, such as small cystoid cavities in the inner nuclear layer (2/15 eyes, 13%), cystoid and/or diffuse edema in the outer nuclear layer (10/15 eyes, 67%), undulations of the photoreceptor ...
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    16. Foveal Photoreceptor Layer in Eyes with Persistent Cystoid Macular Edema Associated with Branch Retinal Vein Occlusion

      A prototype high-speed OCT system was fabricated for patient examinations based on Fourier domain OCT. The system had a sensitivity of 98 dB, a tissue axial resolution of 4.3 μm, and an acquisition rate of approximately 18 700 axial scans per second. Three-dimensional imaging was performed based on a raster-scan protocol. Anatomic features of CSC distinguished by 3-D OCT. A line corresponding to backreflection from the external limiting membrane (ELM) was visible in images from eyes with all sta
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    1-16 of 16
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    Ultrahigh-resolution versus speckle noise-reduction in spectral-domain optical coherence tomography High-Resolution Imaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy Optical Coherence Tomographic Characteristics of Microaneurysms in Diabetic Retinopathy High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies Simon Poole, Cylite co-founder, elected as Fellow of Australian Academy of Science Influence of neoatherosclerosis on prognosis and treatment response in patients with in-stent restenosis Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis Coronary Artery Occlusion Caused by Intramural Hematoma Due to In-Stent Dissection Ocular biometric repeatability using a new high-resolution swept-source optical coherence tomographer IMPROVING ROBUSTNESS USING JOINT ATTENTION NETWORK FOR DETECTING RETINAL DEGENERATION FROM OPTICAL COHERENCE TOMOGRAPHY IMAGES Fluid surface tension evaluation using capillary wave measurement with optical coherence tomography