1. Articles from David Marshall

    1-3 of 3
    1. Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Optical coherence tomography (OCT) has revolutionises the diagnosis of retinal disease based on the detection of microscopic rather than subcellular changes in retinal anatomy. However, currently the technique is limited to the detection of microscopic rather than subcellular changes in retinal anatomy. However, coherence based imaging is extremely sensitive to both changes in optical contrast and cellular events at the micrometer scale, and can generate subtle changes in the spectral content of the OCT image. Here we test the hypothesis that OCT image speckle (image texture) contains information regarding otherwise unresolvable features such as organelle changes arising in the early ...

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    2. Automated choroidal segmentation of 1060 nm OCT in healthy and pathologic eyes using a statistical model

      Automated choroidal segmentation of 1060 nm OCT in healthy and pathologic eyes using a statistical model
      A two stage statistical model based on texture and shape for fully automatic choroidal segmentation of normal and pathologic eyes obtained by a 1060 nm optical coherence tomography (OCT) system is developed. A novel dynamic programming approach is implemented to determine location of the retinal pigment epithelium/ Bruch’s membrane /choriocapillaris (RBC) boundary. The choroid–sclera interface (CSI) is segmented using a statistical model. The algorithm is robust even in presence of speckle noise, low signal (thick choroid), retinal pigment epithelium (RPE) detachments and atrophy, drusen, shadowing and other artifacts. Evaluation against a set of 871 manually segmented cross-sectional scans ...
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    3. Robust segmentation of intraretinal layers in the normal human fovea using a novel statistical model based on texture and shape analysis

      Robust segmentation of intraretinal layers in the normal human fovea using a novel statistical model based on texture and shape analysis
      A novel statistical model based on texture and shape for fully automatic intraretinal layer segmentation of normal retinal tomograms obtained by a commercial 800nm optical coherence tomography (OCT) system is developed. While existing algorithms often fail dramatically due to strong speckle noise, non-optimal imaging conditions, shadows and other artefacts, the novel algorithm’s accuracy only slowly deteriorates when progressively increasing segmentation task difficulty. Evaluation against a large set of manual segmentations shows unprecedented robustness, even in the presence of additional strong speckle noise, with dynamic range tested down to 12dB, enabling segmentation of almost all intraretinal layers in cases previously ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Cardiff University
    2. (3 articles) Wolfgang Drexler
    3. (3 articles) Boris Považay
    4. (2 articles) Medical University of Vienna
    5. (2 articles) Vedran Kajic
    6. (2 articles) Bernd M. Hofer
    7. (1 articles) Marieh Esmaeelpour
    8. (1 articles) Boris Hermann
    9. (1 articles) Sara M. Rey
    10. (1 articles) UCLA
    11. (1 articles) University of Wisconsin
    12. (1 articles) University of St. Andrews
    13. (1 articles) Duke University
    14. (1 articles) Kishan Dholakia
    15. (1 articles) Cynthia A. Toth
    16. (1 articles) Richard B. Rosen
    17. (1 articles) Optovue
    18. (1 articles) Leica
    19. (1 articles) Heidelberg Engineering
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    Robust segmentation of intraretinal layers in the normal human fovea using a novel statistical model based on texture and shape analysis Automated choroidal segmentation of 1060 nm OCT in healthy and pathologic eyes using a statistical model Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY Nonperfusion Assessment in Retinal Vein Occlusion: Comparison between Ultra-Widefield Fluorescein Angiography and Widefield OCT-Angiography Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection Utility of optical coherence tomography angiography in pregnancy-associated central serous chorioretinopathy Multimodal Imaging at Depth Using Innovations in Raman Spectroscopy and Optical Coherence Tomography