1. Articles from Shigenobu Inami

    1-14 of 14
    1. Target lesion evaluation by multiple modalities in vivo: near-infrared spectroscopy (NIRS), virtual histology intravascular ultrasound, optical coherence tomography, and angioscopy

      Target lesion evaluation by multiple modalities in vivo: near-infrared spectroscopy (NIRS), virtual histology intravascular ultrasound, optical coherence tomography, and angioscopy

      A 60-year-old man presented with ischaemic heart failure. We conducted coronary angiography (CAG) after improvement of the heart failure. On CAG, there was a hazy stenosis in the proximal left anterior descending artery (Figure 1, Moving image 1) . The lesion was observed by four modalities: near-infrared spectroscopy (NIRS), virtual histology intravascular ultrasound (VH-IVUS), optical coherence tomography (OCT), and angioscopy. NIRS detected lipid core plaque with echolucency on greyscale IVUS. VH-IVUS showed necrotic core plaque (Figure 1, Moving image 1) . OCT showed lipid-rich plaque, and angioscopy showed yellow intima (Figure 1, Moving image 1) . All modalities could detect lipid content and ...

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    2. Relationship between cholesterol crystals and culprit lesion characteristics in patients with stable coronary artery disease: an optical coherence tomography study

      Relationship between cholesterol crystals and culprit lesion characteristics in patients with stable coronary artery disease: an optical coherence tomography study

      Aims Some recent studies have reported the role of cholesterol crystals (ChCs) in plaque rupture in patients with coronary artery disease. We used optical coherence tomography (OCT) to investigate the characteristics of coronary plaques that were associated with derived ChCs. Methods We evaluated 101 subjects with stable coronary artery disease who underwent OCT. We compared the OCT findings of the culprit lesions with ChCs to those without ChCs and investigated the background characteristics. Results ChCs were observed in culprit lesions of 39 patients. The frequencies of spotty calcification, microchannel structure, and lipid-rich plaque were significantly higher in patients with ChCs ...

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    3. Clear view, clear benefit (editorial)

      Clear view, clear benefit (editorial)

      In this issue of the Journal, a clinical investigation by Ozaki et al focuses on the flushing solution used for image acquisition with frequency-domain optical coherence tomography (FD-OCT). 1 The authors present the cross-sectional area measurement as a quantitative evaluation using low-molecular dextran L (LMD-L) approximate to that of contrast media, and the non-inferiority of LMD-L to contrast media with regard to FD-OCT image quality. Although the cross-sectional and longitudinal images of OCT are analogous with those of intravascular ultrasound (IVUS), the image resolution of OCT is extremely high ( ≈10– 20 μm), which is more than 10-fold that of IVUS ...

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    4. Current status of optical coherence tomography

      Current status of optical coherence tomography
      Optical coherence tomography (OCT) is a novel imaging technology based on low-coherence interferometry that use near-infrared light in real-time, and allows cross-sectional in-situ visualization of the vessel wall at the microscopic level. OCT provides 10-fold higher resolution than intravascular ultrasound which is currently the most used modality for intra-coronary imaging. OCT offers the obvious advantages when characterizing precise plaque microstructure and distinguishing various type of plaques. OCT is also being assessed for its potential role in the understanding of neointimal coverage, vascular healing and the progression of atherosclerosis in coronary vasculature after stenting on the micron scale. These unique capabilities ...
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    5. Coronary angioscopy: current topics and future direction

      Coronary angioscopy: current topics and future direction
      Disruption of vulnerable plaque and following thrombus formation are considered the main cause of acute coronary syndrome (ACS). Intracoronary angioscopy is an endoscopic technology that allows direct visualization of the coronary artery lumen and provides detailed information regarding plaque morphology in patients with coronary artery disease. The color and morphology of coronary plaque under angioscopy observation are proposed to be determinants for plaque stability. Angioscopically yellow plaque represents a thin-cap fibroatheroma, and is associated with a higher incidence of disruption and thrombus formation, and may be associated with future acute coronary syndromes. To circumvent the subjectivity of color interpretation, various ...
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    6. Optical coherence tomography analysis for restenosis of drug-eluting stents

      Optical coherence tomography analysis for restenosis of drug-eluting stents
      Although drug-eluting stents (DES) dramatically reduce the risk of in-stent restenosis (ISR) in comparison to bare-metal stents (BMS) , DES ISR still remains at 5 to 10% in real-world . According to pathological researches, BMS ISR is mainly composed of proliferating smooth muscle cells (SMC). A recent study showed lower effectiveness of DES for target lesion revascularization (TLR) of DES ISR than that of BMS ISR . Therefore, a hypothesis that tissues constituting DES ISR differ from those of BMS ISR has arisen. However, morphology of DES ISR has not been fully investigated. Intracoronary optical coherence tomography (OCT) with high-resolution images (≈15μm) provides ...
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    7. Development of a Novel Prohealing Stent Designed to Deliver Sirolimus From a Biodegradable Abluminal Matrix

      Development of a Novel Prohealing Stent Designed to Deliver Sirolimus From a Biodegradable Abluminal Matrix
      Background— We aimed to demonstrate that, by separating endothelial progenitor cell capture from sirolimus delivery through the application of drug to the abluminal surface of the stent, the degree of endothelialization can be enhanced. Methods and Results— Stainless steel R Stents, with biodegradable SynBiosys polymer coating with sirolimus abluminally applied and surface modified with anti-CD34 antibody were prepared at 2 dosages (low-dose sirolimus [LD-Combo, 2.5 µg sirolimus/mm] and full-dose sirolimus [Combo, 5 µg sirolimus/mm). These Combo stents and the Cypher stent (10 µg sirolimus/mm) were deployed in 98 normal porcine arteries and harvested for pharmacokinetic analysis ...
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    8. Impact of small thrombus formation in restenotic bare-metal stent lesions associated with acute coronary syndrome: Identification by optical coherence tomography

      Abstract: Background: Although in-stent restenosis (ISR) after bare-metal stent (BMS) implantation is considered to be clinically benign, ISR is often associated with adverse complications, such as acute coronary syndrome (ACS). The frequency, type, and location of thrombi in ISR lesions and their clinical presentation have not yet been precisely validated.Methods: Thirty angiographic ISR lesions occurring within 3 to 8months after stenting were evaluated by optical coherence tomography (OCT). A thrombus was defined as a mass protruding into the lumen with an irregular surface, and its type was divided into red or white. The maximum size of a thrombus and ...
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    9. Appearance of Lipid-Laden Intima and Neovascularization After Implantation of Bare-Metal Stents: Extended Late-Phase Observation by Intracoronary Optical Coherence Tomography

      Objectives We examined the neointimal characteristics of bare-metal stents (BMS) in extended late phase by the use of optical coherence tomography (OCT). Background The long-term neointimal features after BMS implantation have not yet been fully characterized. Methods Intracoronary OCT observation of BMS segments was performed during the early phase (<6 months, n = 20) and late phase (≥5 years, n = 21) after implantation. Internal tissue of the BMS was categorized into normal neointima, characterized by a signal-rich band without signal attenuation, or lipid-leaden intima, with marked signal attenuation and a diffuse border. In addition, the presence of disrupted intima and thrombus ...
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    10. Advanced Neointimal Growth is Not Associated With a Low Risk of In-Stent Thrombus: Optical Coherence Tomographic Findings After

      Advanced Neointimal Growth is Not Associated With a Low Risk of In-Stent Thrombus: Optical Coherence Tomographic Findings After
      Background: There is a hypothesis that advanced neointimal stent coverage may protect against stent thrombosis. In the present study, differences in neointimal growth and prevalence of in-stent thrombus between paclitaxel- and sirolimus-eluting stent (PES and SES) were evaluated by optical coherence tomography (OCT). Methods and Results: Follow-up angiographic and OCT examinations at approximately 6 months were performed for 40 patients (20 PES, 20 SES). Late loss was measured by quantitative coronary angiography. Neointimal hyperplasia (NIH) thickness on stent struts was measured by cross-sectional OCT images at 1 mm intervals. After measuring the NIH area in each cross-section, NIH volume was ...
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    11. Delayed Endothelialization After Polytetrafluoroethylene-Covered Stent Implantation for Coronary Aneurysm

      A polytetrafluoroethylene (PTFE)-covered stent is specially used to treat coronary perforation complicating percutaneous intervention in order to prevent the aneurysm from rupturing, but until now it has not been known if endothelialization occurs inside this type of stent. A patient with a giant aneurysm of the right coronary artery underwent successful implantation of a PTFE-covered stent. Angiography at 9-month follow-up showed focal restenosis at the proximal edge of the stent and coronary angioscopy revealed restenosis as a result of thrombus formation. Absence of endothelialization in the covered stent was also detected by angioscopy and optical coherence tomography. These findings ...
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    12. Novel neointimal formation over sirolimus-eluting stents identified by coronary angioscopy and optical coherence tomography

      Novel neointimal formation over sirolimus-eluting stents identified by coronary angioscopy and optical coherence tomography
      eointimal proliferation after sirolimus-eluting stent (SES) implantation is generally inhibited by the pharmacological effects of sirolimus in comparison to bare metal stent (BMS). Neointimal hyperplasia after BMS implantation is mainly composed of vascular smooth muscle cells, and is usually observed as a white mass by angioscopy and as a layer of uniform signal intensity without attenuation on optical coherence tomography (OCT). In this case, angioscopic color of the neointima covering the SES was obviously yellow and OCT signal patterns of the neointima showed rapid attenuation similar to lipid tissues in atherosclerotic lesions. These findings suggest that neointima within the SES ...
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    13. Comparison of Neointimal Coverage by Optical Coherence Tomography of a Sirolimus-Eluting Stent Versus a Bare-Metal Stent Three Months After Implantation

      No detailed data regarding neointimal coverage of bare-metal stents (BMSs) at 3 months after implantation was reported to date. This investigation was designed to evaluate the neointimal coverage of BMSs compared with sirolimus-eluting stents (SESs) using optical coherence tomography. A prospective optical coherence tomographic follow-up examination was performed 3 months after stent implantation for patients who underwent BMS (n = 16) or SES implantation (n = 24). Neointimal hyperplasia (NIH) thickness on each stent strut and percentage of NIH area in each cross section were measured. Malapposition of stent struts to the vessel wall and the existence of in-stent thrombi were also ...
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    14. In Vivo Comparison of Optical Coherence Tomography and Angioscopy for the Evaluation of Coronary Plaque Characteristics

      Atherosclerotic yellow plaques identified by coronary angioscopy are considered as vulnerable plaques. However, characteristics of yellow plaques are not well understood. Optical coherence tomography (OCT) provides accurate tissue characterization in vivo and has the capability to measure fibrous cap thickness covering a lipid plaque. Characteristics of yellow plaques identified by angioscopy were evaluated by OCT. We examined 205 plaques of 41 coronary arteries in 26 patients. In OCT analysis, plaques were classified as fibrous or lipid. Minimal lumen area of the plaque, arch of the lipid, and fibrous cap thickness on the lipid plaque were measured. Yellow grade of the ...
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    1-14 of 14
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    1. (14 articles) Shigenobu Inami
    2. (13 articles) Nippon Medical School
    3. (13 articles) Kyoichi Mizuno
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    Novel neointimal formation over sirolimus-eluting stents identified by coronary angioscopy and optical coherence tomography Advanced Neointimal Growth is Not Associated With a Low Risk of In-Stent Thrombus: Optical Coherence Tomographic Findings After Development of a Novel Prohealing Stent Designed to Deliver Sirolimus From a Biodegradable Abluminal Matrix Optical coherence tomography analysis for restenosis of drug-eluting stents Coronary angioscopy: current topics and future direction Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma 3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT The evaluation of juvenile ocular hypertension by optical coherence tomography angiography