1. Articles from Rebekah A. Drezek

    1-4 of 4
    1. Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have been demonstrated as a useful tool for evaluating resolution and its spatial variation across image volumes in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, 400-nm-diameter iron oxide particles and 1.5-micron-diameter silica ...

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    2. Characterizing the point spread function of retinal OCT devices with a model eye-based phantom

      Characterizing the point spread function of retinal OCT devices with a model eye-based phantom

      We have designed, fabricated, and tested a nanoparticle-embedded phantom (NEP) incorporated into a model eye in order to characterize the point spread function (PSF) of retinal optical coherence tomography (OCT) devices in three dimensions under realistic imaging conditions. The NEP comprises a sparse distribution of highly backscattering silica-gold nanoshells embedded in a transparent UV-curing epoxy. The commercially-available model eye replicates the key optical structures and focusing power of the human eye. We imaged the model eye-NEP combination with a research-grade spectral domain OCT system designed for in vivo retinal imaging and quantified the lateral and axial PSF dimensions across the ...

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    3. Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon

      Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon
      Amy M. Winkler, Photini F. S. Rice, Rebekah A. Drezek et al. Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of co ... [J. Biomed. Opt. 15, 041512 (2010)] published Wed Jul 7, 2010.
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    4. Fluorescent and scattering contrast agents in a mouse model of colorectal cancer

      Fluorescent and scattering contrast agents in a mouse model of colorectal cancer
      Amy M. Winkler, Photini F. S. Rice, Timothy S. Troutman et al. In previous work we have demonstrated the utility of laser-induced fluorescence (LIF) and optical coherence tomography (OCT) to identify adenoma in mouse models of colorectal cancer with high sensitivity and specificity. However, improved sensitivity to early disease, as well as the ability to disti ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 68510L (2008)] published Tue Feb 5, 2008.
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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) Rice University
    2. (2 articles) University of Maryland
    3. (2 articles) FDA
    4. (2 articles) University of Arizona
    5. (2 articles) Anant Agrawal
    6. (2 articles) Yu Chen
    7. (2 articles) Amy M. Winkler
    8. (2 articles) Photini F. S. Rice
    9. (1 articles) Marek Romanowski
    10. (1 articles) Jennifer K. Barton
    11. (1 articles) Academic Medical Center at the University of Amsterdam
    12. (1 articles) Jichi Medical University
    13. (1 articles) University of Milan
    14. (1 articles) Bern University Hospital
    15. (1 articles) Capital Medical University
    16. (1 articles) Nanjing University of Science and Technology
    17. (1 articles) Martin S. Zinkernagel
    18. (1 articles) Junya Ako
    19. (1 articles) Frank D. Verbraak
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    Fluorescent and scattering contrast agents in a mouse model of colorectal cancer Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon Characterizing the point spread function of retinal OCT devices with a model eye-based phantom Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study Longitudinal retinal layer changes in preclinical Alzheimer’s disease Clinical expert consensus document on rotational atherectomy from the Japanese association of cardiovascular intervention and therapeutics Optical coherence tomography features of choroidal neovascularization and their correlation with age, gender and underlying disease