1. Articles from Rebekah A. Drezek

    1-4 of 4
    1. Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have been demonstrated as a useful tool for evaluating resolution and its spatial variation across image volumes in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, 400-nm-diameter iron oxide particles and 1.5-micron-diameter silica ...

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    2. Characterizing the point spread function of retinal OCT devices with a model eye-based phantom

      Characterizing the point spread function of retinal OCT devices with a model eye-based phantom

      We have designed, fabricated, and tested a nanoparticle-embedded phantom (NEP) incorporated into a model eye in order to characterize the point spread function (PSF) of retinal optical coherence tomography (OCT) devices in three dimensions under realistic imaging conditions. The NEP comprises a sparse distribution of highly backscattering silica-gold nanoshells embedded in a transparent UV-curing epoxy. The commercially-available model eye replicates the key optical structures and focusing power of the human eye. We imaged the model eye-NEP combination with a research-grade spectral domain OCT system designed for in vivo retinal imaging and quantified the lateral and axial PSF dimensions across the ...

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    3. Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon

      Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon
      Amy M. Winkler, Photini F. S. Rice, Rebekah A. Drezek et al. Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of co ... [J. Biomed. Opt. 15, 041512 (2010)] published Wed Jul 7, 2010.
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    4. Fluorescent and scattering contrast agents in a mouse model of colorectal cancer

      Fluorescent and scattering contrast agents in a mouse model of colorectal cancer
      Amy M. Winkler, Photini F. S. Rice, Timothy S. Troutman et al. In previous work we have demonstrated the utility of laser-induced fluorescence (LIF) and optical coherence tomography (OCT) to identify adenoma in mouse models of colorectal cancer with high sensitivity and specificity. However, improved sensitivity to early disease, as well as the ability to disti ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 68510L (2008)] published Tue Feb 5, 2008.
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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) Rice University
    2. (2 articles) University of Maryland
    3. (2 articles) FDA
    4. (2 articles) University of Arizona
    5. (2 articles) Anant Agrawal
    6. (2 articles) Yu Chen
    7. (2 articles) Amy M. Winkler
    8. (2 articles) Photini F. S. Rice
    9. (1 articles) Marek Romanowski
    10. (1 articles) Jennifer K. Barton
    11. (1 articles) National Taiwan University
    12. (1 articles) Singapore Eye Research Institute
    13. (1 articles) Columbia University
    14. (1 articles) Seoul National University
    15. (1 articles) UT Southwestern Medical Center
    16. (1 articles) Donald C. Hood
    17. (1 articles) K. Bailey Freund
    18. (1 articles) Carl Zeiss Meditec
    19. (1 articles) Apollo Medical Optics
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    Fluorescent and scattering contrast agents in a mouse model of colorectal cancer Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon Characterizing the point spread function of retinal OCT devices with a model eye-based phantom Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice Optical coherence tomography characteristics of taxane-induced macular edema and other multimodal imaging findings Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration The Use of Optical Coherence Tomography Angiography in the Diagnosis of Inflammatory Type 1 Choroidal Neovascularization Secondary to Tuberculosis: A Case Report Improving the Detection of Glaucoma and Its Progression: A Topographical Approach Vulnerability Zone of Glaucoma Progression in Combined Wide-field Optical Coherence Tomography Event-based Progression Analysis The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Reversal of Edematous Punctal Occlusion