1. Articles from Rebekah A. Drezek

    1-4 of 4
    1. Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have been demonstrated as a useful tool for evaluating resolution and its spatial variation across image volumes in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, 400-nm-diameter iron oxide particles and 1.5-micron-diameter silica ...

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    2. Characterizing the point spread function of retinal OCT devices with a model eye-based phantom

      Characterizing the point spread function of retinal OCT devices with a model eye-based phantom

      We have designed, fabricated, and tested a nanoparticle-embedded phantom (NEP) incorporated into a model eye in order to characterize the point spread function (PSF) of retinal optical coherence tomography (OCT) devices in three dimensions under realistic imaging conditions. The NEP comprises a sparse distribution of highly backscattering silica-gold nanoshells embedded in a transparent UV-curing epoxy. The commercially-available model eye replicates the key optical structures and focusing power of the human eye. We imaged the model eye-NEP combination with a research-grade spectral domain OCT system designed for in vivo retinal imaging and quantified the lateral and axial PSF dimensions across the ...

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    3. Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon

      Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon
      Amy M. Winkler, Photini F. S. Rice, Rebekah A. Drezek et al. Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of co ... [J. Biomed. Opt. 15, 041512 (2010)] published Wed Jul 7, 2010.
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    4. Fluorescent and scattering contrast agents in a mouse model of colorectal cancer

      Fluorescent and scattering contrast agents in a mouse model of colorectal cancer
      Amy M. Winkler, Photini F. S. Rice, Timothy S. Troutman et al. In previous work we have demonstrated the utility of laser-induced fluorescence (LIF) and optical coherence tomography (OCT) to identify adenoma in mouse models of colorectal cancer with high sensitivity and specificity. However, improved sensitivity to early disease, as well as the ability to disti ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 68510L (2008)] published Tue Feb 5, 2008.
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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) Rice University
    2. (2 articles) University of Maryland
    3. (2 articles) FDA
    4. (2 articles) University of Arizona
    5. (2 articles) Anant Agrawal
    6. (2 articles) Yu Chen
    7. (2 articles) Amy M. Winkler
    8. (2 articles) Photini F. S. Rice
    9. (1 articles) Marek Romanowski
    10. (1 articles) Jennifer K. Barton
    11. (1 articles) Northwestern University
    12. (1 articles) Wenzhou Medical College
    13. (1 articles) Jay S. Duker
    14. (1 articles) Joel S. Schuman
    15. (1 articles) Jin Wook Jeoung
    16. (1 articles) Hao F. Zhang
    17. (1 articles) James G. Fujimoto
    18. (1 articles) Cheng Sun
    19. (1 articles) Andre J. Witkin
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    Fluorescent and scattering contrast agents in a mouse model of colorectal cancer Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon Characterizing the point spread function of retinal OCT devices with a model eye-based phantom Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison SPATIAL DISTRIBUTION OF CHORIOCAPILLARIS IMPAIRMENT IN EYES WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION: A Quantitative OCT Angiography Study A Deep Learning Approach in Rebubbling After Descemet's Membrane Endothelial Keratoplasty Impact of optical coherence tomography‐derived neointimal tissue morphology on development of very late in‐stent restenosis Handheld volumetric manual compression‐based quantitative micro‐elastography Comparison of the Iowa Reference Algorithm to the Heidelberg Spectralis optical coherence tomography segmentation algorithm Quantitative assessment of the effect of acute anaerobic exercise on macular perfusion via swept-source optical coherence tomography angiography in young football players Axial length measurement and detection rates using a swept-source optical coherence tomography based biometer in the presence of a dense vitreous hemorrhage Diagnosing Glaucoma with Spectral-domain Optical Coherence Tomography Using Deep Learning Classifier