1. Articles from vishali gupta

    1-24 of 31 1 2 »
    1. Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation

      Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation

      A 50-year-old male presented with recent metamorphopsia in the right eye. Fundus examination revealed bilateral multiple cuticular drusen along with few large colloid drusen (phenotype 3 cuticular drusen). No vitelliform material was evident in the macula in either eye. Fluorescein angiography (FA), indocyanine green angiography (ICGA) did not demonstrate a macular neovascularization (MNV) in either eye. Swept-source optical coherence tomography (SS-OCT) revealed sub-retinal pigment epithelial (RPE) drusen and a clear space beneath the inter-digitation zone and above the RPE-Bruch’s complex. SS-OCTA did not reveal MNV in either eye. The patient was kept under observation, and follow-up at 3 months ...

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    2. Bacillary layer detachment in tubercular choroidal granuloma: A new optical coherence tomography finding

      Bacillary layer detachment in tubercular choroidal granuloma: A new optical coherence tomography finding

      A 32-year-old Asian Indian male presented with sudden-onset and painless decrease in vision in the right eye (OD) for the past 1 day. On examination, his best-corrected visual acuity was 6/24 in OD and 6/6 in the left eye (OS). Anterior segment was quiescent in both eyes. Fundus examination showed ill-defined yellowish subretinal lesions inferior to fovea with surrounding fluid reaching the inferior arcade in OD. A cystic lesion with well-defined borders was seen in the foveal center. Fluorescein angiography (FA) showed early hypofluorescence and late hyperfluorescence indicating active choroidal inflammation. Pooling of dye was appreciated in the ...

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      Mentions: Vishali Gupta
    3. Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Aim To standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis. Methods Members of the International Uveitis Study Group, of the American Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared with uveitis specialists (users) who have less than five publications on the field of uveitis and OCT-A. Results A total of 108 uveitis specialists who participated in the survey were ...

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    4. Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease: A Novel Swept-Source Optical Coherence Tomography Analysis

      Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease: A Novel Swept-Source Optical Coherence Tomography Analysis

      Purpose: To report the frequency, optical coherence tomography (OCT) findings, and visual and anatomic outcomes of patients with acute Vogt-Koyanagi-Harada disease (VKH) presenting with bacillary layer detachment (BLD) (intraretinal split at the photoreceptor inner segment myoid). Methods: This was a retrospective analysis of a consecutive series of VKH patients having a minimum follow-up of 6 months. All patients had swept-source (SS)-OCT, fluorescein angiography (FA), and indocyanine green angiography (ICGA) performed at baseline. The characteristics of serial SS-OCT were recorded and analyzed. Results: Sixty-two subjects (42 females; age: 34.2 ± 12 years) with VKH were included. 118 eyes (95.2 ...

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    5. Longitudinal Follow-up of Tubercular Serpiginous-Like Choroiditis using Optical Coherence Tomography Angiography

      Longitudinal Follow-up of Tubercular Serpiginous-Like Choroiditis using Optical Coherence Tomography Angiography

      Purpose: To analyze and describe serial follow-up of choriocapillaris alterations in tubercular serpiginous like choroiditis (TB SLC) using optical coherence tomography angiography (OCTA) and to compare it with multimodal imaging. Methods: In this prospective cohort study, patients with active TB SLC underwent OCTA using Optovue RTVue XR Avanti® and other imaging including enhanced-depth imaging optical coherence tomography (EDI- OCT ) (Heidelberg Spectralis®), autofluorescence (FAF), fluorescein angiography (FA) and indocyanine green angiography (ICGA). Serial imaging was performed for a total follow-up of 3 months. Choriocapillaris alterations at the site of lesions were analyzed on OCTA imaging and their mean lesion areas (LA ...

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    6. Advances in imaging of uveitis

      Advances in imaging of uveitis

      Advances in multimodal imaging have significantly contributed to the management of many uveitis diseases in recent years. The most significant developments include the use of optical coherence tomography to obtain a more accurate and reproducible assessment of ocular inflammation, the application of optical coherence tomography angiography in choroiditis and retinal vasculitis, new possibilities for studying vitritis with ultrawide field imaging, and the most recent applications of fundus autofluorescence in uveitis. In this review, we provide an overview of the most significant advances in multimodal imaging of uveitis achieved in recent years.

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    7. Intraoperative optical coherence tomography and proportional reflux hydrodissection-guided pars plana vitrectomy for complex severe proliferative diabetic retinopathy

      Intraoperative optical coherence tomography and proportional reflux hydrodissection-guided pars plana vitrectomy for complex severe proliferative diabetic retinopathy

      The study describes the technique of combining microscope-integrated optical coherence tomography (mi-OCT) and proportional reflux hydrodissection (PRH) during pars plana vitrectomy (PPV) in eyes with complex proliferative diabetic retinopathy (PDR) including tractional retinal detachment (TRD), combined retinal detachment (CRD), and taut posterior hyaloid membrane (TPHM). In this technique, PRH is used to create tissue planes between fibrovascular adhesions in areas identified using mi-OCT for insinuating the vitrector, enabling tissue dissection and release of traction. About 46 patients were operated using this technique. 34 eyes had TRD, 9 eyes had CRD, and 3 eyes were diagnosed with TPHM. A second instrument ...

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    8. Swept-source optical coherence tomography angiography of choroidal neovascularization in vertically oriented oval dome-shaped maculopathy

      Swept-source optical coherence tomography angiography of choroidal neovascularization in vertically oriented oval dome-shaped maculopathy

      A 48-year-old female presented with complaints of recent onset diminution of vision of the left eye (OS) for the past 2 months. She was highly myopic and was using glasses for the past 30 years. Ocular examination revealed presence of a myopic fundus with high axial lengths in both the eyes. Fundus examination of the OS revealed a myopic tessellated fundus with prominent choroidal vessels and a blunted foveal reflex. There was a small pale whitish lesion just superior to the foveal center. Optical coherence tomography (OCT) scans (both horizontal and vertical) confirmed presence of dome-shaped maculopathy. There was subretinal ...

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      Mentions: Vishali Gupta
    9. Optical coherence tomography angiography versus fluorescein angiography in diagnosing choroidal neovascularization in chronic central serous chorioretinopathy

      Optical coherence tomography angiography versus fluorescein angiography in diagnosing choroidal neovascularization in chronic central serous chorioretinopathy

      Purpose: Diagnosis of choroidal neovascular membrane (CNVM) is difficult in chronic central serous chorioretinopathy (CCSC) due to overlapping features of both on conventional dye angiography. Optical coherence tomography angiography (OCTA) allows a quick and noninvasive detection of CNVM in these eyes. We compared the fluorescein angiography (FA) features of CNVM with those of OCTA to assess the role of FA in detecting CNVM in CCSC eyes. Methods: Patients with CCSC undergoing FA, spectral domain (SD)-OCT, and OCTA were identified (March 2015–June 2015). Four retina specialists individually reviewed FA images (without OCTA and SD-OCT) to determine whether CNVM was ...

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    10. Current role of optical coherence tomography angiography: Expert panel discussion

      Current role of optical coherence tomography angiography: Expert panel discussion

      Optical coherence tomography (OCT) angiography is a promising technique that provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging and offers several advantages over conventional angiography to visualize the chorioretinal vasculature in a rapid and noninvasive manner. However, as with any evolving imaging technique, there are ongoing challenges in terms of need for new equipment, limitations of imaging capability and software processing techniques, as well as in understanding the implications of the imaging and its correlation with pathophysiology of the retina and choroid. This ...

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    11. Type 2 Choroidal Neovascularization in a Choroidal Granuloma Detected Using Swept-Source Optical Coherence Tomography Angiography

      Type 2 Choroidal Neovascularization in a Choroidal Granuloma Detected Using Swept-Source Optical Coherence Tomography Angiography

      The authors describe the imaging characteristics and progression of a type 2 choroidal neovascular membrane (CNV) using swept-source optical coherence tomography (SS-OCTA). A 27-year-old male presented with an active possible tubercular choroidal granuloma associated with exudative retinal detachment in the right eye. The patient received anti-tubercular drugs, oral corticosteroids, and intravitreal bevacizumab and showed complete resolution in 3 months. At the 7-month follow-up, SS-OCTA imaging revealed a type 2 CNV. SS-OCTA is a very useful tool to detect and monitor the growth of CNV in active and healed posterior uveitis without the risks of dye-based angiography.

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      Mentions: Vishali Gupta
    12. DETECTION OF TYPE 1 CHOROIDAL NEOVASCULAR MEMBRANES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN TUBERCULAR POSTERIOR UVEITIS

      DETECTION OF TYPE 1 CHOROIDAL NEOVASCULAR MEMBRANES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN TUBERCULAR POSTERIOR UVEITIS

      Purpose: To study optical coherence tomography angiography (OCTA) and multimodal imaging features of Type 1 inflammatory choroidal neovascularization (CNV) in tubercular serpiginous-like choroiditis and response to anti–vascular endothelial growth factor therapy. Methods: In this study, multimodal imaging was performed using OCTA, enhanced-depth imaging optical coherence tomography, fluorescein angiography, and indocyanine green angiography . Correlation of OCTA with other imaging modalities in the detection of CNV was performed. The changes in CNV configuration after anti–vascular endothelial growth factor therapy were assessed. Results: In this study, nine eyes (8 patients; 5 females; mean age: 32.5 ± 11.57 years) with diagnosis ...

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      Mentions: Vishali Gupta
    13. Optical coherence tomography angiography features of bilateral retinopathy associated with Chikungunya fever

      Optical coherence tomography angiography features of bilateral retinopathy associated with Chikungunya fever

      A 66-year-old male patient presented with decreased vision in both eyes following episode of Chikungunya fever. Examination revealed bilateral retinal lesions with stippled pigmentary changes at the level of the choriocapillaris, involving the macula in the left eye. The retinopathy consisted of outer retinal disruption and retinochoroidal flow abnormalities detected using with additional imaging, including spectral-domain optical coherence tomography (OCT), autofluorescence, and OCT angiography (OCTA). The index case report describes unique OCTA findings in both eyes of an elderly male secondary to Chikungunya fever. Using the technique of OCTA, insights into the mechanisms of visual damage in viral retinopathies such ...

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      Mentions: Vishali Gupta
    14. Optical coherence tomography angiography features of acute macular neuroretinopathy in dengue fever

      Optical coherence tomography angiography features of acute macular neuroretinopathy in dengue fever

      A 39-year-old female with dengue fever presented with decreased vision in both eyes. Visual acuity was 20/200 and 20/80 in the right eye (OD) and left eye (OS), respectively. Fundus showed granular, grayish-white lesions in the parafoveal region in OD. Multimodal imaging including optical coherence tomography angiography (OCTA), optical coherence tomography (OCT), and fluorescein angiography (FA) was performed. FA showed late hyperfluorescence with few microaneurysms in OS. OCT showed hyperreflectivity in various layers, suggestive of acute macular neuroretinopathy (AMN). OCTA showed disruption of retinal capillary plexuses. This case shows how OCTA provides newer insights into the pathogenesis of ...

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      Mentions: Vishali Gupta
    15. Pearls and pitfalls of optical coherence tomography angiography in the multimodal evaluation of uveitis

      Pearls and pitfalls of optical coherence tomography angiography in the multimodal evaluation of uveitis

      Background Optical coherence tomography angiography (OCTA) employs a novel imaging algorithm that detects the amplitude or phase decorrelation of blood cell movement. It thus provides a flow map with depth-resolved visualization of the various vascular layers in the posterior pole of the eye including the retina capillary plexus and the choroid. In the past 3 years, the number of research papers on the subject of OCTA in retinal diseases has grown exponentially including important applications in the field of uveitis. While the study of OCTA in uveitic diseases has gained remarkable relevance worldwide, interpretation can be challenging, and many limitations ...

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      Mentions: UCLA Vishali Gupta
    16. Analysis of Retinochoroidal Vasculature in Human Immunodeficiency Virus Infection Using Spectral-Domain OCT Angiography

      Analysis of Retinochoroidal Vasculature in Human Immunodeficiency Virus Infection Using Spectral-Domain OCT Angiography

      Purpose To describe the retinochoroidal vascular alterations in patients with human immunodeficiency virus (HIV) infection using en face OCT angiography (OCTA). Design Cross-sectional study. Participants Twenty-six patients with HIV infection (5 women, with and without HIV retinopathy) were included in the study. Nineteen healthy participants (7 women) with no known ocular disease were recruited as healthy controls. Methods Multimodal imaging was performed using OCTA (Optovue RTVue XR Avanti; Optovue, Inc, Fremont, CA), enhanced-depth imaging OCT (Heidelberg Spectralis; Heidelberg Engineering, Heidelberg, Germany), color fundus photography, and fluorescein angiography (FA). Vessel flow density (VFD) was calculated automatically by the OCTA software. Morphologic ...

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    17. The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases

      The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases

      Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse. This review aims to establish the basis ...

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    18. Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging

      Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging

      Background The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. OCTA images were analyzed for alterations in retinochoroidal microvasculature. Results Thirty-four eyes (24 patients; 10 with VKH and 14 with CSC) were included. OCTA en face images showed apparent areas of choriocapillaris flow void due to shadowing effect from ...

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      Mentions: Vishali Gupta
    19. Morphological differences between optic disc collaterals and neovascularization on optical coherence tomography angiography

      Morphological differences between optic disc collaterals and neovascularization on optical coherence tomography angiography

      Background To study morphological features of optic disc venous collaterals (OVCs) and neovascularization of optic disc (NVD) on optical coherence tomography angiography (OCTA). Methods Patients with OVCs and NVDs secondary to ischemic retinal diseases were prospectively enrolled. Multimodal imaging was performed using color fundus photography, fluorescein angiography (FA), and OCTA. Morphological evaluation of en-face structural OCT, cross-sectional and en-face OCTA was performed. Results Twenty eyes (20 patients; OVCs: n  = 10 and NVD: n  = 10) were included. OVCs appeared as small, loopy vessels distinct from surrounding peripapillary capillaries on OCTA in the radial peripapillary capillary frame. NVDs appeared as a mesh ...

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      Mentions: Vishali Gupta
    20. Optical Coherence Tomography Angiography Reveals Choriocapillaris Flow Reduction in Placoid Chorioretinitis

      Optical Coherence Tomography Angiography Reveals Choriocapillaris Flow Reduction in Placoid Chorioretinitis

      Purpose To elucidate the origin of disease in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and related placoid disorders, and to determine the principle tissue level of involvement: retinal pigment epithelium (RPE) versus choriocapillaris (CC). To determine the prevalence, extent, and persistence of choroidal flow reduction in placoid chorioretinitis using en face optical coherence tomography (OCT) and OCT angiography (OCTA). Design Multicenter, prospective case series. Participants Patients with a clinical diagnosis of APMPPE, persistent placoid maculopathy (PPM), or relentless placoid chorioretinitis (RPC). Methods Morphologic evaluation of en face structural OCT and OCTA images with customized segmentation through the deep capillary ...

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    21. The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt–Koyanagi–Harada Disease

      The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt–Koyanagi–Harada Disease

      Purpose : To report the imaging characteristics of acute Vogt–Koyanagi–Harada (VKH) disease using optical coherence tomography angiography (OCTA). Methods : In this prospective study, patients with acute VKH ( n = 10; mean age: 30.5 ± 13.43 years) underwent multimodal imaging (baseline and follow-up) using fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA), OCT, and OCTA. The OCTA images were analyzed to assess the retinochoroidal vasculature and compared with other imaging techniques. Results : During the active stage, all eyes showed multiple foci of choriocapillaris flow void that correlated with ICGA. These foci decreased in number and size after initiation of ...

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      Mentions: Vishali Gupta
    22. Spectral domain optical coherence tomography changes following intravitreal dexamethasone implant, Ozurdex ® in patients with uveitic cystoid macular edema

      Spectral domain optical coherence tomography changes following intravitreal dexamethasone implant, Ozurdex ® in patients with uveitic cystoid macular edema

      Purpose: To correlate the structural and functional changes following intravitreal injection of dexamethasone 0.7 mg (Ozurdex ® ) implant in patients with recalcitrant uveitic cystoid macular edema (CME). Materials and Methods: In a prospective, interventional, nonrandomized study, 30 eyes (27 patients) with uveitic CME received Ozurdex ® implant and were followed-up for 24 weeks at periodic intervals to monitor structural alterations seen on spectral domain optical coherence tomography (SD-OCT). The outcome measures included change in central macular thickness (CMT) and best-corrected visual acuity (BCVA) as well as structural alterations seen on OCT such as change in the height of cystoid spaces (CSs ...

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    23. Atlas Optical Coherence Tomography of Macular Diseases and Glaucoma Fourth Edition (Book)

      Atlas Optical Coherence Tomography of Macular Diseases and Glaucoma Fourth Edition (Book)

      Optical Coherence Tomography (OCT) is a non-invasive, non contact, transpupillary imaging technology which can image two-dimensional retinal structures in vivo with a resolution of 10 to 17 microns. The fourth edition of this atlas has been completely updated to provide the latest thinking and technology developments in the use of OCT in macular diseases and glaucoma. Beginning with an introduction to OCT, the following section discusses its use with a range of conditions and disorders associated with macular diseases such as macular hole, foveal haemorrhage and retinal trauma. The final section examines the use of OCT for diagnosis and management ...

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