1. Articles from Joseph M. Backer

    1-2 of 2
    1. In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model

      In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model
      Purpose: Increased vascular endothelial growth factor (VEGF) receptor expression has been found at the sites of angiogenesis, particularly in tumor growth areas, as compared with quiescent vasculature. An increase in VEGF receptor-2 is associated with colon cancer progression. The in vivo detection of VEGF receptor is of interest for the purposes of studying basic mechanisms of carcinogenesis, making clinical diagnoses, and monitoring the efficacy of chemopreventive and therapeutic agents. In this study, a novel single chain (sc)VEGF-based molecular probe is utilized in the azoxymethane (AOM)-treated mouse model of colorectal cancer to study delivery route and specificity for disease ...
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    2. Fluorescent and scattering contrast agents in a mouse model of colorectal cancer

      Fluorescent and scattering contrast agents in a mouse model of colorectal cancer
      Amy M. Winkler, Photini F. S. Rice, Timothy S. Troutman et al. In previous work we have demonstrated the utility of laser-induced fluorescence (LIF) and optical coherence tomography (OCT) to identify adenoma in mouse models of colorectal cancer with high sensitivity and specificity. However, improved sensitivity to early disease, as well as the ability to disti ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 68510L (2008)] published Tue Feb 5, 2008.
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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Arizona
    2. (2 articles) Amy M. Winkler
    3. (2 articles) Photini F. S. Rice
    4. (1 articles) Jan Weichsel
    5. (1 articles) Marina V. Backer
    6. (1 articles) Marek Romanowski
    7. (1 articles) Jennifer K. Barton
    8. (1 articles) Joseph M. Backer
    9. (1 articles) Harvard University
    10. (1 articles) Thomas Jefferson University
    11. (1 articles) Massachusetts General Hospital
    12. (1 articles) Nippon Medical School
    13. (1 articles) Kyung Hee University
    14. (1 articles) Wakayama Medical University
    15. (1 articles) Masamichi Takano
    16. (1 articles) Carol L. Shields
    17. (1 articles) Ik-Kyung Jang
    18. (1 articles) Kyoichi Mizuno
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