1. Articles from Photini F. S. Rice

    1-6 of 6
    1. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must first be separated from the image background using the process ...

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    2. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depthresolved, high-resolution images of biological tissue in real time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to quantitatively assess the diagnostic potential of OCT for ovarian cancer imaging; however, due to small organ size, the ovaries must rst be separated from the image background using the ...

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    3. Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer

      Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer

      Optical coherence tomography (OCT) is a minimally-invasive imaging modality capable of tracking the development of individual colonic adenomas. As such, OCT can be used to evaluate the mechanisms and effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer models. The data presented here represent part of a larger study evaluating α-difluoromethylornithine (DFMO) and Sulindac as chemopreventive and chemotherapeutic agents using mice treated with the carcinogen azoxymethane (AOM). 27 A/J mice were included in the chemoprevention study, subdivided into four treatment groups (No Drug, DFMO, Sulindac, DFMO/Sulindac). 30 mm lateral images of each colon at eight different rotations were ...

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    4. In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model

      In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model
      Purpose: Increased vascular endothelial growth factor (VEGF) receptor expression has been found at the sites of angiogenesis, particularly in tumor growth areas, as compared with quiescent vasculature. An increase in VEGF receptor-2 is associated with colon cancer progression. The in vivo detection of VEGF receptor is of interest for the purposes of studying basic mechanisms of carcinogenesis, making clinical diagnoses, and monitoring the efficacy of chemopreventive and therapeutic agents. In this study, a novel single chain (sc)VEGF-based molecular probe is utilized in the azoxymethane (AOM)-treated mouse model of colorectal cancer to study delivery route and specificity for disease ...
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    5. Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon

      Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon
      Amy M. Winkler, Photini F. S. Rice, Rebekah A. Drezek et al. Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of co ... [J. Biomed. Opt. 15, 041512 (2010)] published Wed Jul 7, 2010.
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    6. Fluorescent and scattering contrast agents in a mouse model of colorectal cancer

      Fluorescent and scattering contrast agents in a mouse model of colorectal cancer
      Amy M. Winkler, Photini F. S. Rice, Timothy S. Troutman et al. In previous work we have demonstrated the utility of laser-induced fluorescence (LIF) and optical coherence tomography (OCT) to identify adenoma in mouse models of colorectal cancer with high sensitivity and specificity. However, improved sensitivity to early disease, as well as the ability to disti ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 68510L (2008)] published Tue Feb 5, 2008.
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    1-6 of 6
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  2. Topics in the News

    1. (6 articles) University of Arizona
    2. (6 articles) Photini F. S. Rice
    3. (5 articles) Jennifer K. Barton
    4. (3 articles) Amy M. Winkler
    5. (1 articles) Rice University
    6. (1 articles) Jan Weichsel
    7. (1 articles) Marina V. Backer
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    Fluorescent and scattering contrast agents in a mouse model of colorectal cancer Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies Simon Poole, Cylite co-founder, elected as Fellow of Australian Academy of Science Influence of neoatherosclerosis on prognosis and treatment response in patients with in-stent restenosis Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis Coronary Artery Occlusion Caused by Intramural Hematoma Due to In-Stent Dissection Ocular biometric repeatability using a new high-resolution swept-source optical coherence tomographer