1. Articles from Amy M. Winkler

    1-7 of 7
    1. Using optical coherence tomography to characterize thick-glaze structure: Chinese Southern Song Guan glaze case study

      Using optical coherence tomography to characterize thick-glaze structure: Chinese Southern Song Guan glaze case study

      This study explores the structure characteristics of thick glaze, in terms of the case study of Chinese Southern Song Guan (SSG) ware, focusing on the bubble and its media structure, using a novel focus-tracking optical coherence tomography (OCT) system. The OCT images we obtained not only unveil the structural uniqueness of the thick-glaze SSG sample, but also establish a distinguishable structural pattern for aiding authentication. In addition, information revealed in our images provides a logical explanation for the subtle texture and tone of SSG glaze as well as insights into the technologies used in layering and firing these thick glazes.

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    2. In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model

      In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model
      Purpose: Increased vascular endothelial growth factor (VEGF) receptor expression has been found at the sites of angiogenesis, particularly in tumor growth areas, as compared with quiescent vasculature. An increase in VEGF receptor-2 is associated with colon cancer progression. The in vivo detection of VEGF receptor is of interest for the purposes of studying basic mechanisms of carcinogenesis, making clinical diagnoses, and monitoring the efficacy of chemopreventive and therapeutic agents. In this study, a novel single chain (sc)VEGF-based molecular probe is utilized in the azoxymethane (AOM)-treated mouse model of colorectal cancer to study delivery route and specificity for disease ...
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    3. Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon

      Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon
      Amy M. Winkler, Photini F. S. Rice, Rebekah A. Drezek et al. Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of co ... [J. Biomed. Opt. 15, 041512 (2010)] published Wed Jul 7, 2010.
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    4. New scheme for polarimetric glucose sensing without polarizers

      New scheme for polarimetric glucose sensing without polarizers
      Polarimetric glucose sensing is a promising method for noninvasive estimation of blood glucose concentration. Published methods of polarimetric glucose sensing generally rely on measuring the rotation of light as it traverses the aqueous humor of the eye. In this article, an interferometer is described that can detect polarization changes due to glucose without the use of polarization control or polarization analyzing elements. Without polarizers, this system is sensitive to optical activity, inherent to glucose, but minimally sensitive to linear retardance, inherent to the cornea. The underlying principle of the system was experimentally verified using spectral domain optical coherence tomography. A ...
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    5. Laparoscopic optical coherence tomography imaging of human ovarian cancer

      Objectives Ovarian cancer is the fourth leading cause of cancer-related death among women in the US largely due to late detection secondary to unreliable symptomology and screening tools without adequate resolution. Optical coherence tomography (OCT) is a recently emerging imaging modality with promise in ovarian cancer diagnostics, providing non-destructive subsurface imaging at imaging depths up to 2 mm with near-histological grade resolution (10–20 μm). In this study, we developed the first ever laparoscopic OCT (LOCT) device, evaluated the safety and feasibility of LOCT, and characterized the microstructural features of human ovaries in vivo. Methods A custom LOCT device was ...
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    6. Inherent homogenous media dispersion compensation in frequency domain optical coherence tomography by accurate k-sampling

      Alexandre R. Tumlinson, Bernd Hofer, Amy M. Winkler, Boris Považay, Wolfgang Drexler, Jennifer K. Barton. Depth dependent broadening of the axial point spread function due to dispersion in the imaged media, and algorithms for postprocess correction, have been previously described for both time domain and frequency domain optical coherence tomography. We show that homogeneous media dispersion artifacts ... [Appl. Opt. 47, 687-693 (2008)]
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    7. Fluorescent and scattering contrast agents in a mouse model of colorectal cancer

      Fluorescent and scattering contrast agents in a mouse model of colorectal cancer
      Amy M. Winkler, Photini F. S. Rice, Timothy S. Troutman et al. In previous work we have demonstrated the utility of laser-induced fluorescence (LIF) and optical coherence tomography (OCT) to identify adenoma in mouse models of colorectal cancer with high sensitivity and specificity. However, improved sensitivity to early disease, as well as the ability to disti ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 68510L (2008)] published Tue Feb 5, 2008.
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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) University of Arizona
    2. (7 articles) Amy M. Winkler
    3. (6 articles) Jennifer K. Barton
    4. (3 articles) Photini F. S. Rice
    5. (2 articles) Garret T. Bonnema
    6. (1 articles) Rice University
    7. (1 articles) Jan Weichsel
    8. (1 articles) Marek Romanowski
    9. (1 articles) John R. Davis
    10. (1 articles) Joseph M. Backer
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    Fluorescent and scattering contrast agents in a mouse model of colorectal cancer New scheme for polarimetric glucose sensing without polarizers Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model Using optical coherence tomography to characterize thick-glaze structure: Chinese Southern Song Guan glaze case study Retinal Vascular Features in Ocular Blunt Trauma by Optical Coherence Tomography Angiography Non-invasive imaging of a choroidal macrovessel Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Digital Wavefront Sensing Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study