1. Articles from Vasilica Crecea

    1-6 of 6
    1. High Resolution Phase-Sensitive Magnetomotive Optical Coherence Microscopy for Tracking Magnetic Microbeads and Cellular Mechanics

      High Resolution Phase-Sensitive Magnetomotive Optical Coherence Microscopy for Tracking Magnetic Microbeads and Cellular Mechanics

      We present a real-time multimodal near-infrared imaging technology that tracks externally-induced axial motion of magnetic microbeads in single cells in culture. The integrated multimodal imaging technique consists of phase-sensitive magnetomotive optical coherence microscopy (MM-OCM) and multiphoton microscopy (MPM). MPM is utilized for the visualization of multifunctional fluorescent and magnetic microbeads, while MM-OCM detects, with nanometer-scale sensitivity, periodic displacements of the microbeads induced by the modulation of an external magnetic field. Magnetomotive signals are measured from mouse macrophages, human breast primary ductal carcinoma cells, and human breast epithelial cells in culture, and validated with full-field phase-sensitive microscopy. This methodology demonstrates the ...

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    2. Magnetomotive optical coherence tomography

      Magnetomotive optical coherence tomography
      A spectral-domain magnetomotive optical coherence tomography apparatus, includes (a) a spectral-domain optical coherence tomography device, and (b) a magnet. The magnet is coupled with the optical coherence tomography device so that changes in the magnetic field are coordinated with collection of data by the optical coherence tomography device. This device may be used to examine a sample by spectral-domain magnetomotive optical coherence tomography, which includes examining the sample with a spectral-domain optical coherence tomography device, to collect optical coherence tomography data. The sample contains magnetic particles, and the magnetic particles are subjected to a changing magnetic field during the examining.
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    3. Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials

      Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials
      The availability of a real-time non-destructive modality to interrogate the mechanical properties of viscoelastic materials would facilitate many new investigations. We introduce a new optical method for measuring elastic properties of samples which employs magnetite nanoparticles as perturbative agents. Magnetic nanoparticles distributed in silicone-based samples are displaced upon probing with a small external magnetic field gradient and depth-resolved optical coherence phase shifts allow for the tracking of scatterers in the sample with nanometer-scale sensitivity. The scatterers undergo underdamped oscillations when the magnetic field is applied step-wise, allowing for the measurement of the natural frequencies of oscillation of the samples. Validation ...
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    4. Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues

      Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues
      Magnetic nanoparticles (MNPs) are increasingly important in magnetic resonance and biomedical optical imaging. We describe a method for imaging MNPs by detecting nanoscale displacements using a phase-resolved spectral-domain optical coherence tomography (OCT) system. Biological tissues and phantoms are exposed to ~800 G magnetic fields modulated at 56 and 100 Hz to mechanically actuate embedded iron oxide MNPs (~20 nm diameter). Sensitivity to 27 μg/g (~2 nM) MNPs within tissue phantoms is achieved by filtering paramagnetic from diamagnetic vibrations. We demonstrate biological feasibility by imaging topically applied MNPs during their diffusion into an excised rat tumor over a 2 hour ...
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    5. Optical micro-scale mapping of dynamic biomechanical tissue properties

      Optical micro-scale mapping of dynamic biomechanical tissue properties
      Xing Liang, Amy L. Oldenburg, Vasilica Crecea, Eric J. Chaney, Stephen A. Boppart Mechanical forces such as adhesion, shear stress and compression play crucial roles in tissue growth, patterning and development. To understand the role of these mechanical stimuli, it is of great importance to measure biomechanical properties of developing, engineered, and natural tissues. To ... [Opt. Express 16, 11052-11065 (2008)]
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    6. Modeling and measurement of tissue elastic moduli using optical coherence elastography

      Xing Liang, Amy L. Oldenburg, Vasilica Crecea et al. Mechanical forces play crucial roles in tissue growth, patterning and development. To understand the role of mechanical stimuli, biomechanical properties are of great importance, as well as our ability to measure biomechanical properties of developing and engineered tissues. To enable these measurem ... [Proc. SPIE Int. Soc. Opt. Eng. 6858, 685803 (2008)] published Tue Feb 5, 2008.
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    1-6 of 6
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  2. Topics in the News

    1. (5 articles) University of Illinois at Urbana-Champaign
    2. (5 articles) Amy L. Oldenburg
    3. (5 articles) Stephen A. Boppart
    4. (4 articles) Vasilica Crecea
    5. (4 articles) Xing Liang
    6. (2 articles) Kyungpook National University
    7. (2 articles) University of Washington
    8. (2 articles) Jeehyun Kim
    9. (2 articles) Ruchire Eranga Wijesinghe
    10. (2 articles) Mansik Jeon
    11. (1 articles) Gabriel Popescu
    12. (1 articles) Eric J. Chaney
    13. (1 articles) Tyler S. Ralston
    14. (1 articles) University of Ulsan
    15. (1 articles) Tokyo Medical & Dental University
    16. (1 articles) University of Toronto
    17. (1 articles) Yasunori Sumi
    18. (1 articles) Ali M. Fard
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    Optical micro-scale mapping of dynamic biomechanical tissue properties Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials Magnetomotive optical coherence tomography High Resolution Phase-Sensitive Magnetomotive Optical Coherence Microscopy for Tracking Magnetic Microbeads and Cellular Mechanics A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations Vision-Inspection-Synchronized Dual Optical Coherence Tomography for High-Resolution Real-Time Multidimensional Defect Tracking in Optical Thin Film Industry Relative retinal flow velocity detection using optical coherence tomography angiography imaging Comparison of Optical Flow Ratio and Fractional Flow Ratio in Stent-Treated Arteries Immediately After Percutaneous Coronary Intervention Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions Retinal Thickness and Microvascular Pattern in Early Parkinson's Disease Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice