1. Articles from I. Meglinski

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    1. Noninvasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles

      Noninvasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles

      The studies were carried out on groups of clinically healthy mice line of outbred CD-1 stock. The model animals were divided into 2 groups and received experimental liposomal formulations. Using the method of fluorescence spectroscopy, we investigated the effectiveness of penetration into the circulatory system of fluorescently stained liposomes with polyethylene glycol (PEG) and without PEG when administered orally. Fluorescence channel with a fiber probe series of multifunctional laser non-invasive diagnostic system “LAKK-M” (SPE “LAZMA” Ltd, Russia) was used as the measuring equipment.

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    2. Mapping of spatial distribution of superficial blood vessels in human skin by double correlation analysis of optical coherence tomography images

      Mapping of spatial distribution of superficial blood vessels in human skin by double correlation analysis of optical coherence tomography images

      2D/3D spatial distribution of superficial blood vessels in human skin in vivo was conducted by double correlation analysis of the swept source Optical Coherence Tomography (OCT) images. An adaptive Wiener filtering technique has been employed to remove background noise and increase the overall quality of the OCT images acquired experimentally. Correlation Mapping and Fourier domain correlation approaches have been subsequently applied to enhance spatial resolution of images of vascular network in human skin. The analysis of images performed on Graphics Processing Units (GPUs) utilizing the recently developed Compute Unified Device Architecture (CUDA) framework.

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    3. Assessment of transcutaneous vaccine delivery by optical coherence tomography

      Assessment of transcutaneous vaccine delivery by optical coherence tomography

      Immunization is one of the most efficient and cost-effective means for the prevention of diseases. The latest trend for inducing protective immunity is topical application of vaccines to intact skin rather than invasive administration via injection. Apart from being a non-invasive route of drug delivery, skin itself also offers advantages through the presence of cells of the immune system in both the dermis and epidermis. However, vaccine penetration through the outermost layers of skin is limited by the barrier provided by the Stratum corneum. In the current study utilizing conventional Optical Coherence Tomography (OCT) we investigate the transcutaneous delivery of ...

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    4. In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography

      In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography
      Author(s): P O Bagnaninchi, Y Yang, M Bonesi, G Maffulli, C Phelan, I Meglinski, A El Haj and N MaffulliAffiliation(s): Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK; Cranfield Health, Cranfield University, Cranfield MK43 0AL, UK; Department of Pathology, University Hospital of North Staffordshire, Stoke-on-Trent ST4 7QB, UK
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    5. Doppler optical coherence tomography in cardiovascular applications

      Doppler optical coherence tomography in cardiovascular applications

      Abstract  The study of flow dynamics in complex geometry vessels is highly important in various biomedical applications where the knowledge of the mechanic interactions between the moving fluid and the housing media plays a key role for the determination of the parameters of interest, including the effect of blood flow on the possible rupture of atherosclerotic plaques. Doppler Optical Coherence Tomography (DOCT), as a functional extension of Optical Coherence Tomography (OCT), is an optic, non-contact, noninvasive technique able to achieve detailed analysis of the flow/vessel interactions. It allows simultaneous high resolution imaging (∼10 µm typical) of the morphology and ...

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    6. Optical coherence tomography: A potential tool for unsupervised prediction of treatment response for Port-Wine Stains

      Background: Treatment of Port-Wine Stains (PWS) suffers from the absence of a reliable real-time tool for monitoring a clinical endpoint. Response to treatment varies substantially according to blood vessel geometry. Even though optical coherence tomography (OCT) has been identified as a modality with potential to suit this need, it has not been introduced as a standard clinical monitoring tool. One reason could be that – although OCT acquires data in real-time – gigabyte data transfer, processing and communication to a clinician may impede the implementation as a clinical tool. Objectives: We investigate whether an automated algorithm can address this problem. Methods: Based ...
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    7. Optical properties of human tendons characterized by Psoct and their relation to tendinopathy: a clinical study

      Polarisation-sensitive optical coherence tomography (PSOCT) is a non destructive technique with great potential for tendinopathy diagnosis. Functional optical assessment can be used in operating theatres to delineate in depth the margin of the non-healthy area, and limit the amount of tissue to be r ... [Proc. SPIE Int. Soc. Opt. Eng. 6854, 68541C (2008)] published Tue Feb 12, 2008.
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    8. Imaging of flow velocity profiles within the complex geometry vessels by Doppler optical coherence tomography

      Doppler Optical Coherence Tomography (DOCT) technique was applied to non-invasive monitoring of cross-sectional velocity profiles distributions within complex geometry vessels. A set of micro vessels of different diameters with T-shaped and Y-shaped bifurcation and vessels with aneurysm were built. ... [Proc. SPIE Int. Soc. Opt. Eng. 6855, 68550B (2008)] published Wed Feb 6, 2008.
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    1-8 of 8
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  2. Topics in the News

    1. (8 articles) Igor V. Meglinski
    2. (5 articles) National Institutes of Health
    3. (3 articles) University of Otago
    4. (2 articles) Cranfield University
    5. (1 articles) University of Oulu
    6. (1 articles) University of Sheffield
    7. (1 articles) Gloucestershire Royal Hospital
    8. (1 articles) Ying Yang
    9. (1 articles) Florian Bazant-Hegemark
    10. (1 articles) Nick Stone
    11. (1 articles) Alexander V. Bykov
    12. (1 articles) University of Houston
    13. (1 articles) University of Minnesota
    14. (1 articles) Indiana University
    15. (1 articles) Yale University
    16. (1 articles) Massachusetts Institute of Technology
    17. (1 articles) James G. Fujimoto
    18. (1 articles) Taner Akkin
    19. (1 articles) Donald T. Miller
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    Doppler optical coherence tomography in cardiovascular applications In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography Assessment of transcutaneous vaccine delivery by optical coherence tomography Mapping of spatial distribution of superficial blood vessels in human skin by double correlation analysis of optical coherence tomography images Noninvasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles Indiana University Receives NIH Grant for Imaging Spatial and Temporal Dynamics of Retinal Ganglion Cells University of Houston Receives NIH Grant for Structural and Molecular Phenotyping of Embryonic Development Through Multi-Modal Optical Imaging. Massachusetts Institute of Technology Receives NIH Grant for Novel Optical Diagnostics with Optical Coherence Tomography Yale University Receives a NIH Grant for Xenopus As A Model System for Hydrocephaly and Ependymal Ciliogenesis University of Minnesota Receives NIH Grant for Optical Imaging of Neural Activity Based on Lorentz Effect Skin Imaging to Inform Laser Treatments Diabetes and Fundus OCT: 1st Edition (Textbook)