1. Articles from Toshio Hisatomi

    1-8 of 8
    1. Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography

      Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography

      Purpose To evaluate the retinal structure-function relationships in the macula of retinitis pigmentosa (RP) patients by comparing microperimetry-3 (MP-3) images with co-registered optical coherence tomography (OCT) images. Methods Thirty patients with typical RP were recruited from our hospital. The maculae of patients were examined with MP-3 and OCT. The retinal sensitivity was measured by MP-3 at 40 testing points arranged concentrically in a 16° diameter of the central retina, and we divided the 40 points into four zones according to degree from the fovea (2°, 4°, 6°, and 8°). We analyzed the correlation coefficients between the retinal sensitivity and the ...

      Read Full Article
    2. Microaneurysm Imaging using Multiple En Face Optical Coherence Tomography Angiography Image Averaging: Morphology and Visualization

      Microaneurysm Imaging using Multiple En Face Optical Coherence Tomography Angiography Image Averaging: Morphology and Visualization

      Purpose In diabetic retinopathy (DR), optical coherence tomography angiography (OCTA) could not image all fluorescein angiography (FA)-detected microaneurysms. We investigated if multiple image averaging could enhance its microaneurysm detection capability in DR. Design Prospective- and cross-sectional observational study. Participants Consecutive 31 patients (n = 62 eyes) with DR. Methods All eyes underwent FA, and 3 x 3 mm fovea-centered OCTA images were obtained using two devices (RTVue XR Avanti: Optovue Inc. and OCT HS-100: Canon Inc.). OCTA imaging (HS-100) was performed ten consecutive times. Microaneurysm detection capability was compared among five OCTA images (single image, 3x, 5x, and 10x averaged ...

      Read Full Article
    3. Retinal flow density by optical coherence tomography angiography is useful for detection of nonperfused areas in diabetic retinopathy

      Retinal flow density by optical coherence tomography angiography is useful for detection of nonperfused areas in diabetic retinopathy

      Purpose Fluorescein angiography (FA) has been conventionally used for detection of retinal nonperfused area (NPA) in diabetic retinopathy (DR) in spite of its qualitative evaluation. Optical coherence tomography angiography (OCTA) has been recently reported to be useful for the quantification of retinal vascular disorder in DR. In this study, we examined whether retinal flow density (FD) measurement in OCTA was useful for NPA detection in DR. Methods The study included 41 eyes from 29 patients with DR who underwent FA and OCTA. Regions surrounded by arteries or veins were extracted in the OCTA image, and the FDs in each region ...

      Read Full Article
    4. Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy

      Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy

      Purpose : Our purpose is to evaluate the spatial bias of macular capillary dropout accompanying diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods : This study included 47 patients with diabetes and 29 healthy individuals who underwent OCTA. Retinal capillary flow density (FD) of 2.6 × 2.6 or 5.2 × 5.2 mm foveal area as well as the four divided areas (superior, inferior, temporal, nasal) without a foveal avascular zone (FAZ) at the superficial capillary plexus and deep capillary plexus (DCP) were measured respectively using ImageJ and NI Vision. Spatial biases of FD (orientation bias ratio and hierarchical ...

      Read Full Article
    5. Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa

      Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa

      Purpose To investigate the macular microvasculature changes by optical coherence tomography angiography (OCTA) and analyse the correlation between these changes and central visual function in patients with retinitis pigmentosa (RP). Methods We measured the area of the foveal avascular zone (FAZ) and the foveal and parafoveal flow density (FFD and PFD, respectively) in the superficial (S) and deep (D) retinal plexus by OCTA (AngioVue) and compared these values between 73 RP patients and 36 healthy controls. We analysed the relationships between these microvasculature measurements and central visual functions such as visual acuity (VA) and the values of static perimetry tests ...

      Read Full Article
    6. INDIVIDUALIZED, SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY–GUIDED FACEDOWN POSTURING AFTER MACULAR HOLE SURGERY: Minimizing Treatment Burden and Maximizing Outcome

      INDIVIDUALIZED, SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY–GUIDED FACEDOWN POSTURING AFTER MACULAR HOLE SURGERY: Minimizing Treatment Burden and Maximizing Outcome

      Purpose: To evaluate the individualized, optical coherence tomography-guided facedown posturing after macular hole (MH) surgery in minimizing the burden and maximizing outcome. Methods: A retrospective comparative study. One hundred and seven consecutive eyes with an MH (<500 μ m) received vitrectomy and gas tamponade. After surgery, optical coherence tomography examination was performed from 6 hours to postoperative Day 2. In Group A, with a pro re nata posturing protocol, the duration of facedown posturing was determined from the optical coherence tomography findings. Group A was subdivided as follows: Group A1, facedown posturing required postoperatively and Group A2, no posturing required. When ...

      Read Full Article
    7. OCT Predicts VEGF Levels in Human Eyes

      OCT Predicts VEGF Levels in Human Eyes

      Sonoda et al . 1 reported a new aspect of diagnostic imaging by optical coherence tomography (OCT) in their manuscript, “Correlation between reflectivity of subretinal fluid in OCT images and concentration of intravitreal VEGF in eyes with diabetic macular edema.” Neudorfer and the authors found that OCT reflectivity is variable in subretinal fluid in diabetic macula edema cases. 2 They have already reported the cytokine profiles in diabetic retinopathy cases from intra-operative vitreous samples. 3 In this manuscript, they examined the correlation between OCT reflectivity and the intravitreal concentration of major cytokines/growth factors, VEGF, IL-6, and IL-8. To test the ...

      Read Full Article
    8. Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

      Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization
      Purpose The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. Methods CNV lesions were induced in rats using laser photocoagulation. The utility of NP for in vivo imaging and gene delivery was evaluated by coupling the NP with a green fluorescing protein plasmid (NP-GFPg). Rhodamine labeling (Rd-NP) was used to localize NP in choroidal flatmounts. Rd-NP-GFPg particles were injected intravenously on weeks 1, 2, or 3. In the treatment arm, rats received NP containing a ...
      Read Full Article
    1-8 of 8
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (4 articles) Kyushu University
    2. (2 articles) Tatsuro Ishibashi
    3. (1 articles) Massachusetts Eye and Ear Infirmary
    4. (1 articles) Stanford University
    5. (1 articles) Harvard University
    6. (1 articles) Tokyo Medical & Dental University
    7. (1 articles) Massachusetts Institute of Technology
    8. (1 articles) Andrea Giani
    9. (1 articles) Optovue
    10. (1 articles) Topcon Medical Systems
  3. Popular Articles

  4. Picture Gallery

    Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization OCT Predicts VEGF Levels in Human Eyes INDIVIDUALIZED, SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY–GUIDED FACEDOWN POSTURING AFTER MACULAR HOLE SURGERY: Minimizing Treatment Burden and Maximizing Outcome Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy Retinal flow density by optical coherence tomography angiography is useful for detection of nonperfused areas in diabetic retinopathy Microaneurysm Imaging using Multiple En Face Optical Coherence Tomography Angiography Image Averaging: Morphology and Visualization Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography Postdoctoral opening in optical instrumentation and retinal imaging at University of Illinois at Chicago Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol Optical coherence tomography versus intravascular ultrasound for culprit lesion assessment in patients with acute myocardial infarction Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study