1. Articles from M. Bonesi

    1-8 of 8
    1. Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length

      Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length

      We demonstrate, for the first time, OCT imaging capabilities of a novel, akinetic (without any form of movement in the tuning mechanism), all-semiconductor, all-electronic tunable, compact and flexible swept source laser technology at 1550 nm and 1310 nm. To investigate its OCT performance, 2D and 3D ex vivo and in vivo OCT imaging was performed at different sweep rates, from 20 kHz up to 200 kHz, with different axial resolutions, about 10 µm to 20 µm, and at different coherence gate displacements, from zero delay to >17 cm. Laser source phase linearity and phase repeatability standard deviation of <2 mrad ...

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    2. In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography

      In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography
      Author(s): P O Bagnaninchi, Y Yang, M Bonesi, G Maffulli, C Phelan, I Meglinski, A El Haj and N MaffulliAffiliation(s): Institute for Science and Technology in Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK; Cranfield Health, Cranfield University, Cranfield MK43 0AL, UK; Department of Pathology, University Hospital of North Staffordshire, Stoke-on-Trent ST4 7QB, UK
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    3. Doppler optical coherence tomography in cardiovascular applications

      Doppler optical coherence tomography in cardiovascular applications

      Abstract  The study of flow dynamics in complex geometry vessels is highly important in various biomedical applications where the knowledge of the mechanic interactions between the moving fluid and the housing media plays a key role for the determination of the parameters of interest, including the effect of blood flow on the possible rupture of atherosclerotic plaques. Doppler Optical Coherence Tomography (DOCT), as a functional extension of Optical Coherence Tomography (OCT), is an optic, non-contact, noninvasive technique able to achieve detailed analysis of the flow/vessel interactions. It allows simultaneous high resolution imaging (∼10 µm typical) of the morphology and ...

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    4. Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography

      Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography

      We have applied a compact low power rapid scanning Doppler Optical Coherence Tomography system to monitor multi-dimensional velocity profiles within the complex vessels and simultaneous real-time non-invasive imaging of skin tissues morphology in vivo, in the wavelength range of 1.3–1.5 nm. Optical clearing of skin tissues has been utilized to achieve depth of OCT images up to 1.7 mm. Current approach enables applying low-power (0.4–0.5 mW) and low-noise broadband near-infrared light sources and obtaining OCT images with down to 12 μm spatial resolution. Two-dimensional time-domain OCT images of complex flow velocity profiles in ...

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    5. Using swept source optical coherence tomography to monitor wound healing in tissue engineered skin

      Using swept source optical coherence tomography to monitor wound healing in tissue engineered skin
      There is an increasing need for a robust simple to use non-invasive imaging technology for monitoring tissue engineered constructs as they develop. We have applied optical coherence tomography (OCT), a relatively new optical technique, to image tissue engineered constructs. Our aim was to evaluate the use of swept-source optical coherence tomography (SSOCT) to non-invasively image reconstructed skin as it developed over several weeks. The epidermis of the reconstructed skin was readily distinguished from the neodermis when examined with standard histology - a destructive imaging technique - of samples. The development of reconstructed skin based on deepithelialised acellular dermis (DED) was accurately monitored ...
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    6. Novel optical imaging technique to determine the 3-D orientation of collagen fibers in cartilage: variable-incidence angle polarization-sensitive optical coherence tomography

      Objective To investigate a novel optical method to determine the three dimensional (3-D) structure of articular cartilage collagen non-destructively. Methods Polarization-sensitive optical coherence tomography was used to determine the apparent optical birefringence of articular cartilage for a number of different illumination directions. A quantitative method based on the theory of light propagation in uniaxial crystalline materials was validated on equine flexor tendon. Qualitative maps of fiber polar and azimuthal orientation at sites on the posterior and anterior segments of the equine third metacarpophalangeal (fetlock) joint were produced, and the azimuthal orientations compared with data from a split-line experiment. Results Polar ...
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    7. Optical properties of human tendons characterized by Psoct and their relation to tendinopathy: a clinical study

      Polarisation-sensitive optical coherence tomography (PSOCT) is a non destructive technique with great potential for tendinopathy diagnosis. Functional optical assessment can be used in operating theatres to delineate in depth the margin of the non-healthy area, and limit the amount of tissue to be r ... [Proc. SPIE Int. Soc. Opt. Eng. 6854, 68541C (2008)] published Tue Feb 12, 2008.
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    8. Imaging of flow velocity profiles within the complex geometry vessels by Doppler optical coherence tomography

      Doppler Optical Coherence Tomography (DOCT) technique was applied to non-invasive monitoring of cross-sectional velocity profiles distributions within complex geometry vessels. A set of micro vessels of different diameters with T-shaped and Y-shaped bifurcation and vessels with aneurysm were built. ... [Proc. SPIE Int. Soc. Opt. Eng. 6855, 68550B (2008)] published Wed Feb 6, 2008.
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    1-8 of 8
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  2. Topics in the News

    1. (4 articles) Medical University of Vienna
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    5. (1 articles) Insight Photonic Solutions
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    Using swept source optical coherence tomography to monitor wound healing in tissue engineered skin Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography Doppler optical coherence tomography in cardiovascular applications In-depth imaging and quantification of degenerative changes associated with Achilles ruptured tendons by polarization-sensitive optical coherence tomography Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length Optical Coherence Tomography of the Middle Ear Using Ossiview Role of Optical Coherence Tomography Angiography Imaging in Patients with Diabetes Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes Investigation of Micro-motion Kinematics of Continuum Robots for Volumetric OCT and OCT-guided Visual Servoing Association of Myopia With Microvascular Alterations in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study Accuracy of Total Corneal Power Calculation for Multifocal Toric Intraocular Lens Implantation: Swept-Source OCT-Based Biometer vs Scheimpflug Tomographer Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy