1. Articles from Li Li

    1-12 of 12
    1. Comparison of Color Fundus Photography, Infrared Fundus Photography, and Optical Coherence Tomography in Detecting Retinal Hamartoma in Patients with Tuberous Sclerosis Complex

      Comparison of Color Fundus Photography, Infrared Fundus Photography, and Optical Coherence Tomography in Detecting Retinal Hamartoma in Patients with Tuberous Sclerosis Complex

      Background: A sensitive method is required to detect retinal hamartomas in patients with tuberous sclerosis complex (TSC). The aim of the present study was to compare the color fundus photography, infrared imaging (IFG), and optical coherence tomography (OCT) in the detection rate of retinal hamartoma in patients with TSC. Methods: This study included 11 patients (22 eyes) with TSC, who underwent color fundus photography, IFG, and spectral-domain OCT to detect retinal hamartomas. TSC1 and TSC2 Results: The mean age of the 11 patients was 8.0 ± 2.1 years. The mean spherical equivalent was −0.55 ± 1.42 D by ...

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    2. Histological validation of frequency domain optical coherence tomography for the evaluation of neointimal formation after a novel polymer-free sirolimus-eluting stent implantation

      Histological validation of frequency domain optical coherence tomography for the evaluation of neointimal formation after a novel polymer-free sirolimus-eluting stent implantation

      Novel polymer-free drug-eluting stents have been developed to reduce polymer-related adverse events. However, neointimal coverage after polymer-free DES implantation is unclear and validation between optical coherence tomography (OCT) and histology is required. Sixteen polymer-free sirolimus-eluting stents were randomly implanted into coronary arteries of 8 normal swine. OCT and histological measurement were conducted at 3 or 6 months after stent placement. For quantitative measures, lumen area, stent area, neointimal area and neointimal thickness were validated in every single OCT and histology matched cross-section. Moreover, for qualitative analysis, OCT signal patterns of neointimal tissue were classified as homogeneous, layered and heterogeneous patterns ...

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      Mentions: Li Li
    3. Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts

      Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts

      Epilepsy mapping with high spatial and temporal resolution has great significance for both fundamental research on epileptic neurons and the clinical management of epilepsy. In this communication, we demonstrate for the first time in vivo epilepsy mapping with high spatial and temporal resolution and dual optical contrasts in an animal model. Through the variations of a depthresolved optical coherence tomography signal with optical scattering contrast, we observed that epileptic neuron activities modulated the optical refractive index of epileptic neurons and their surrounding tissue. Simultaneously, through neurovasculature coupling mechanisms and optical absorption contrast, we used photoacoustic signals to document the hemodynamic ...

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    4. Optical coherence computed tomography

      Optical coherence computed tomography

      A system, method, and device for imaging a sample. In embodiments, a light from a low-coherence source or a wavelength-swept source is used to illuminate the sample. Pathlength-resolved intensity profiles of the light reemitted from the sample are recorded and measurements are taken. A reconstruction algorithm is used to invert the pathlength-resolved measurements to form an image.

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    5. Investigation of Neovascularization in Three-Dimensional Porous Scaffolds In Vivo by a Combination of Multiscale Photoacoustic Microscopy and Optical Coherence Tomography

      Investigation of Neovascularization in Three-Dimensional Porous Scaffolds In Vivo by a Combination of Multiscale Photoacoustic Microscopy and Optical Coherence Tomography

      It is a grand challenge to visualize and assess in vivo neovascularization in a three-dimensional (3D) scaffold non-invasively, together with high spatial resolution and deep penetration depth. Here we used multiscale photoacoustic microscopy (PAM), including acoustic-resolution PAM (AR-PAM) and optical-resolution PAM (OR-PAM), to chronically monitor neovascularization in an inverse opal scaffold implanted in a mouse model up to six weeks by taking advantage of the optical absorption contrast intrinsic to hemoglobin molecules in red blood cells. By combining with optical coherence tomography (OCT) based on optical scattering contrast, we also demonstrated the capability to simultaneously image and analyze the vasculature ...

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    6. Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging

      Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging
      Recently developed optical-resolution photoacoustic microscopy (OR-PAM), which is based on the detection of optical absorption contrast, is complementary to other optical microscopy modalities such as optical confocal microscopy, optical coherence tomography, and multiphoton microscopy. A hybrid optical–mechanical scanning configuration increases the imaging speed of OR-PAM significantly, facilitating many demanding biomedical applications. With a high-pulse-repetition-rate laser, the hybrid-scanning OR-PAM can acquire one-dimensional depth-resolved images (A-lines) at 5 kHz and two-dimensional B-scan images containing 800 A-lines at 6.25 Hz. We demonstrated in vivo in a mouse three-dimensional imaging of the iris vasculature in 128 s for an 800×800×200 ...
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    7. In vivo, dual-modality imaging of mouse eyes: optical coherence tomography and photoacoustic microscopy within a single instrument

      In vivo, dual-modality imaging of mouse eyes: optical coherence tomography and photoacoustic microscopy within a single instrument
      Optical-resolution photoacoustic microscopy (OR-PAM) provides superb optical absorption contrast for red blood cells (RBCs), which makes it ideal for in vivo microvasculature imaging. In comparison, optical coherence tomography (OCT), widely used for tissue microstructure imaging, provides high optical scattering contrast. The two contrast mechanisms are highly complementary. In this work, we combined OR-PAM and OCT into a single, dual-modality imaging instrument for in vivo mouse eye imaging. We demonstrated in vivo dual-modality imaging of the anterior segment of mouse eyes with laser pulse energy within the ANSI laser safety standard.
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    8. Fast-scanning reflection-mode integrated optical-coherence and photoacoustic microscopy

      Fast-scanning reflection-mode integrated optical-coherence and photoacoustic microscopy
      We previously demonstrated that multimodal microscopy combining photoacoustic microscopy and optical coherence tomography can provide comprehensive insight into biological tissue at µm-level resolution by exploiting both optical absorption and scattering contrasts. Recently, we have developed a second-generation integrated photoacoustic and optical-coherence microscope, which can potentially be adapted for clinical applications. In this new system, we can perform photoacoustic and optical-coherence imaging simultaneously at a speed of 5,000 A-lines per second with real-time on-screen display. Also, both modalities now work in reflection mode instead of transmission mode, allowing easy access to various anatomical locations of interest. Imaging of skin and ...
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    9. Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies

      Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies
      Photoacoustic microscopy is predominantly sensitive to optical absorption, while optical coherence tomography relies on optical backscattering. Integrating their complementary contrasts can provide comprehensive information about biological tissue. We have developed a dual-modality microscope that combines the two for studying microcirculation. Three-dimensional imaging of microvasculature and its local environment has been demonstrated at micrometer-order resolution using endogenous contrast in vivo.
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    10. In-vivo imaging of microcirculation using integrated photoacoustic and optical-coherence microscopy

      Photoacoustic imaging and optical coherence tomography have complementary imaging contrasts. Photoacoustic imaging is sensitive to optical absorption, thus is able to generate detailed maps of deep microvasculature in vivo. Optical coherence tomography exploits the optical scattering contrast, and can provide real-time, micrometer-resolution imaging of tissue. We integrate an optical-resolution photoacoustic microscopy and a spectral-domain optical coherence tomography into a single system. Our preliminary experiments showed that it could be a valuable imaging tool for microcirculation studies in vivo.
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    11. Optical coherence computed tomography

      Li Li and Lihong V. Wang We proposed a novel time-resolved optical tomography, optical coherence computed tomography. It married the key concepts of time-resolved diffuse optical tomography and optical coherence tomography. Both ballistic and multiple-scattered photons were measured at multiple source-detection positions by ... [Proc. SPIE Int. Soc. Opt. Eng. 6855, 68550H (2008)] published Wed Feb 6, 2008.
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    12. Optical coherence computed tomography

      Li Li and Lihong V. Wang Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA A time-resolved optical tomography, optical coherence computed tomography, is proposed to bridge the gap between diffuse optical tomography and optical coherence tomography. Both ballistic and multiple-scattered photons are measured at multiple source-detection positions by low-coherence interferometry providing a temporal resolution smalle
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    1-12 of 12
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  2. Topics in the News

    1. (12 articles) Li Li
    2. (10 articles) Washington University in St. Louis
    3. (10 articles) Lihong V. Wang
    4. (6 articles) Konstantin I. Maslov
    5. (2 articles) Geng Ku
    6. (2 articles) Kyungpook National University
    7. (2 articles) University of Washington
    8. (2 articles) Jeehyun Kim
    9. (2 articles) Ruchire Eranga Wijesinghe
    10. (2 articles) Mansik Jeon
    11. (1 articles) Harvard University
    12. (1 articles) University of Maryland
    13. (1 articles) Massachusetts General Hospital
    14. (1 articles) Capital Medical University
    15. (1 articles) Thorlabs
    16. (1 articles) University of Ulsan
    17. (1 articles) Tokyo Medical & Dental University
    18. (1 articles) University of Toronto
    19. (1 articles) Yasunori Sumi
    20. (1 articles) Ali M. Fard
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    Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies Fast-scanning reflection-mode integrated optical-coherence and photoacoustic microscopy In vivo, dual-modality imaging of mouse eyes: optical coherence tomography and photoacoustic microscopy within a single instrument Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging Investigation of Neovascularization in Three-Dimensional Porous Scaffolds In Vivo by a Combination of Multiscale Photoacoustic Microscopy and Optical Coherence Tomography Optical coherence computed tomography Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations Vision-Inspection-Synchronized Dual Optical Coherence Tomography for High-Resolution Real-Time Multidimensional Defect Tracking in Optical Thin Film Industry Relative retinal flow velocity detection using optical coherence tomography angiography imaging Comparison of Optical Flow Ratio and Fractional Flow Ratio in Stent-Treated Arteries Immediately After Percutaneous Coronary Intervention Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions