1. Articles from Maria Radu

    1-9 of 9
    1. Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview

      Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview

      By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT) is a light-based technology with a tissue penetration of approximately 1 to 3 mm and provides near histological resolution. It has emerged as a technological breakthrough in intravascular imaging with multiple clinical and research applications. OCT provides detailed visualization of the vessel following PCI and provides accurate assessment of post-procedural stent performance including detection of edge dissection, stent struts apposition, tissue prolapse, and healing ...

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    2. Expert review document part 2: methodology, terminology and clinical applications of optical coherence tomography for the assessment of interventional procedures

      Expert review document part 2: methodology, terminology and clinical applications of optical coherence tomography for the assessment of interventional procedures

      Introduction This document is complementary to an Expert Review Document on Optical Coherence Tomography (OCT) for the study of coronary arteries and atherosclerosis.1 The goal of this companion manuscript is to provide a practical guide framework for the appropriate use and reporting of the novel frequency domain (FD) OCT imaging to guide interventional procedures, with a particular interest on the comparison with intravascular ultrasound (IVUS).1–4 Technique for optical coherence tomography imaging In the OCT Expert Review Document on Atherosclerosis, a comprehensive description of the physical principles for OCT imaging and time domain (TD) catheters (St Jude Medical ...

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    3. Serial Analysis of the Malapposed and Uncovered Struts of the New Generation of Everolimus-Eluting Bioresorbable Scaffold With Optical Coherence Tomography

      Serial Analysis of the Malapposed and Uncovered Struts of the New Generation of Everolimus-Eluting Bioresorbable Scaffold With Optical Coherence Tomography

      Objectives The aim of this study is to assess the serial changes in strut apposition and coverage of the bioresorbable vascular scaffolds (BVS) and to relate this with the presence of intraluminal masses at 6 months with optical coherence tomography (OCT). Background Incomplete strut/scaffold apposition (ISA) and uncovered struts are related to a higher risk of scaffold thrombosis. Bioresorbable vascular scaffolds can potentially avoid the risk of scaffold thrombosis because of its complete resorption. However, during the resorption period, the risk of scaffold thrombosis is unknown. Methods OCT was performed in 25 patients at baseline and 6 months. Struts ...

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    4. Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from benchwork to clinical application

      Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from benchwork to clinical application

      Fully bioresorbable everolimus-eluting vascular scaffolds (BVS: Abbott Vascular) are a novel approach to treating coronary lesions. The ABSORB cohort A and cohort B trials investigated the implantation of 3 mm BVS, up to a maximum length of 18 mm, in simple lesions only, The implantation of overlapping BVS in longer lesions has not previously been reported.

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    5. Optical coherence tomography at follow-up after percutaneous coronary intervention: relationship between procedural dissections, stent strut malapposition and stent healing

      Optical coherence tomography at follow-up after percutaneous coronary intervention: relationship between procedural dissections, stent strut malapposition and stent healing
      Aims: To analyze the relationship between strut appoition as visualized with optical coherence tomography (OCT) at follow-up and clinical and procedural characteristics at stent implantation, and to examine the relationship between strut apposition and stent healing.
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    6. Evaluation with in vivo optical coherence tomography and histology of the vascular effects of the everolimus-eluting bioresorbable vascular scaffold at two years following implantation in a healthy porcine coronary artery model: implications of pilot resu

      Evaluation with in vivo optical coherence tomography and histology of the vascular effects of the everolimus-eluting bioresorbable vascular scaffold at two years following implantation in a healthy porcine coronary artery model: implications of pilot resu
      To quantify with in vivo OCT and histology, the device/vessel interaction after implantation of the bioresorbable vascular scaffold (BVS). We evaluated the area and thickness of the strut voids previously occupied by the polymeric struts, and the neointimal hyperplasia (NIH) area covering the endoluminal surface of the strut voids (NIH(EV)), as well as the NIH area occupying the space between the strut voids (NIH(BV)), in healthy porcine coronary arteries at 2, 3 and 4 years after implantation of the device. Twenty-two polymeric BVS were implanted in the coronary arteries of 11 healthy Yucatan minipigs that underwent OCT ...
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    7. Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from bench-work to clinical application

      Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from bench-work to clinical application

      Fully bioresorbable everolimus-eluting vascular scaffolds are a novel approach to treating coronary lesions. The ABSORB cohort A and cohort B trials investigated the implantation of 3 mm BV, up to a maximum length of 18 mm, in simple lesions only.

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    8. Strut apposition after coronary stent implantation visualised with optical coherence tomography

      Strut apposition after coronary stent implantation visualised with optical coherence tomography
      Aim: To describe different patterns of stent strut apposition, as visualized with Optical Coherence Tomography. Conclusion: For a detailed analysis of strut apposition with OCT, we reconstructed strut thickness and estimated stent- and vessel wall areas. With this method, we found four types of strut apposition, where pseudoapposed struts constitute a type of struts not previously described. The clinical importance of pseudoapposed struts remains to be settled.
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    1-9 of 9
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    Strut apposition after coronary stent implantation visualised with optical coherence tomography Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from bench-work to clinical application Evaluation with in vivo optical coherence tomography and histology of the vascular effects of the everolimus-eluting bioresorbable vascular scaffold at two years following implantation in a healthy porcine coronary artery model: implications of pilot resu Optical coherence tomography at follow-up after percutaneous coronary intervention: relationship between procedural dissections, stent strut malapposition and stent healing Optical coherence tomography (OCT) of overlapping bioresorbable scaffolds: from benchwork to clinical application 3D Reconstructions of Optical Frequency Domain Imaging to Improve Understanding of Conventional PCI Serial Analysis of the Malapposed and Uncovered Struts of the New Generation of Everolimus-Eluting Bioresorbable Scaffold With Optical Coherence Tomography Expert review document part 2: methodology, terminology and clinical applications of optical coherence tomography for the assessment of interventional procedures Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview KU Leuven leads €6 million research project on heart disease and dementia Gabor optical coherence tomographic angiography (GOCTA) (Part II): theoretical basis of sensitivity improvement and optimization for processing speed Retinal Neovascularization–Simulating Retinal Capillary Reperfusion in Branch Retinal Vein Occlusion, Imaged by Wide-Field Optical Coherence Tomography Angiography