1. Articles from ce zheng

    1-10 of 10
    1. Effect of optic disc–fovea distance on the normative classifications of macular inner retinal layers as assessed with OCT in healthy subjects

      Effect of optic disc–fovea distance on the normative classifications of macular inner retinal layers as assessed with OCT in healthy subjects

      Purpose To determine the influence of the optic disc–fovea distance (DFD) on the normative classifications based on thickness measurements of macular inner retinal layers with spectral-domain optical coherence tomography (OCT) in healthy subjects. Methods A total of 182 eyes from 182 healthy subjects were included (mean (SD) spherical equivalent −0.8 (1.9) dioptres). We performed macula and optic disc imaging with the Topcon 3D OCT 2000. The thickness of the macular inner retinal layers (macular retinal nerve fibre layer (mRNFL), ganglion cell-inner plexiform layer (GCIPL) and both combined (ganglion cell complex; GCC)) and the corresponding classifications based on ...

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    2. Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ...

      Purpose To investigate the profile and determinants of retinal optical intensity in normal subjects using 3D spectral domain optical coherence tomography (SD OCT). Methods A total of 231 eyes from 231 healthy subjects ranging in age from 18 to 80 years were included and underwent a 3D OCT scan. Forty-four eyes were randomly chosen to be scanned by two operators for reproducibility analysis. Distribution of optical intensity of each layer and regions specified by the Early Treatment of Diabetic Retinopathy Study (ETDRS) were investigated by analyzing the OCT raw data with our automatic graph-based algorithm. Univariate and multivariate analyses were ...

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    3. Pretreatment Anterior Segment Imaging During Acute Primary Angle Closure: Insights into Angle Closure Mechanisms in the Acute Phase

      Pretreatment Anterior Segment Imaging During Acute Primary Angle Closure: Insights into Angle Closure Mechanisms in the Acute Phase

      Objective To describe anterior segment optical coherence tomography (ASOCT) parameters during acute primary angle closure (APAC) before therapeutic interventions and comparative analyses of biometric parameters of APAC eyes with fellow eyes. Design Prospective, comparative case series. Participants Thirty-one consecutive patients with APAC. Methods All patients underwent ASOCT imaging of both eyes during the attack, before therapeutic interventions were administered. Custom software was used to measure anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV), iris curvature (I-Curv), iris area (I-Area), lens vault (LV), and angle opening distance (AOD750), trabecular iris space area (TISA750), and iris thickness (IT750 ...

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    4. Assessment of trabecular meshwork width using swept source optical coherence tomography

      Assessment of trabecular meshwork width using swept source optical coherence tomography

      Purpose Measurements of the angle width by ultrasound biomicroscopy or anterior segment optical coherence tomography are usually performed 500 μm from the scleral spur, as the anterior part of trabecular meshwork (TM) is assumed to lie within this distance. The aim of this study was to measure TM width using swept source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan), and to investigate factors influencing this measurement. Methods Participants underwent gonioscopy and SS-OCT imaging in the dark. High-definition SS-OCT images were corrected for refractive distortion; and customized software (ImageJ; National Institutes of Health, Bethesda, MD, USA) was utilized ...

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    5. Analysis of Anterior Segment Dynamics Using Anterior Segment Optical Coherence Tomography Before and After Laser Peripheral Iridotomy

      Analysis of Anterior Segment Dynamics Using Anterior Segment Optical Coherence Tomography Before and After Laser Peripheral Iridotomy

      Objective To evaluate changes in the speed of pupil constriction and in anterior segment parameters after laser peripheral iridotomy (LPI) in patients with angle closure using anterior segment optical coherence tomography. Methods In this prospective observational study, videos of pupil and anterior segment changes in response to illumination were captured with real-time video recording using anterior segment optical coherence tomography and were analyzed frame by frame before and after LPI. Customized software was used to measure the speed of pupil constriction and changes in anterior chamber depth and anterior chamber area, as well as iris thickness at 750 μm from ...

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    6. Swept source optical coherence tomography measurement of the iris–trabecular contact (ITC) index: a new parameter for angle closure

      Swept source optical coherence tomography measurement of the iris–trabecular contact (ITC) index: a new parameter for angle closure

      Purpose To evaluate the inter- and intra-observer agreement of measurement of the iris–trabecular contact (ITC) index, a measure of the degree of angle closure, using swept source optical coherence tomography (SSOCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan). Methods One randomly selected eye of 60 subjects was imaged under dark room conditions. The SSOCT 3-dimensional angle scan simultaneously obtains 128 radial scans of the anterior chamber for the entire circumference of the angle. Post-imaging analysis estimated the ITC index using in-built software. For intra-observer agreement for image grading, one examiner performed the grading twice in a masked fashion and random ...

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    7. Quantitative Assessment of Changes in Trabeculectomy Blebs After Laser Suture Lysis Using Anterior Segment Coherence Tomography

      Quantitative Assessment of Changes in Trabeculectomy Blebs After Laser Suture Lysis Using Anterior Segment Coherence Tomography
      Purpose: To quantify changes in bleb morphology after laser suture lysis (LSL) using anterior segment optical coherence tomography (AS-OCT). Patients and Methods: This was a prospective observational case series of patients who underwent trabeculectomy surgery with mitomycin-C and required subsequent LSL. Subjects were assessed before and immediately after LSL, and at 3 months after LSL. At each visit, a standardized cross-sectional AS-OCT image of the bleb was obtained, from which a masked observer measured bleb height (hB), cavity height (hC), wall cross sectional area (AW), cavity cross sectional area (AC), and bleb cross sectional area (AB) using custom software. Results ...
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      Mentions: Tin Aung
    8. Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark

      Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark
      Objective To propose the Schwalbe line (SL) as a new anatomical landmark, independent of the scleral spur (SS) location, for assessing anterior chamber angle (ACA) width quantitatively with high-definition optical coherence tomography (HD-OCT). Methods Study subjects underwent dark-room gonioscopy and HD-OCT in one randomly selected eye. The authors developed a computer-aided program to define two new quantitative parameters for assessing ACA width: Schwalbe line-angle opening distance (SL-AOD) measured at the SL, and Schwalbe line-trabecular–iris space area (SL-TISA) measured 500 µm from the SL. The associations between SL parameters, SS parameters and gonioscopic grading were evaluated. Results Seventy-three (47 females ...
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    9. Changes in Angle Configuration After Phacoemulsification Measured by Anterior Segment Optical Coherence Tomography.

      Purpose: To measure changes in angle width after phacoemulsification and intraocular lens (IOL) implantation using anterior segment optical coherence tomography (AS-OCT). Materials and Methods: Twenty-one patients undergoing cataract surgery were recruited from the National University Hospital, Singapore. AS-OCT images were obtained of nasal and temporal angle quadrants before and at 1-month after surgery. Optical measurements of central anterior chamber depth were obtained, and gonioscopic measurement of angle width was recorded. AS-OCT angle width parameters measured in the nasal and temporal quadrants included the angle opening distance at 500 [mu]m (AOD500) anterior to the scleral spur and the trabecular iris ...

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    10. Changes in anterior segment morphology in response to illumination and after laser iridotomy in Asian eyes: an anterior segment OCT study

      Aim: Using the anterior segment optical coherence tomography (AS-OCT) to quantify changes in anterior segment morphology going from light to dark and following laser iridotomy (LI). Methods: Prospective observational study. 17 consecutive subjects without peripheral anterior synechiae undergoing LI were evaluated using gonioscopy and AS-OCT. Angle configuration including angle opening distance (AOD) at 500 microns anterior to the scleral spur, AOD500, trabecular-iris space area up to 750 microns from the scleral spur, TISA750 and the increase in angle opening going from dark to light conditions was determined. Results: Both mean AOD500 and TISA750 increased nearly threefold going from dark to ...

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    1-10 of 10
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  2. Topics in the News

    1. (7 articles) Tin Aung
    2. (6 articles) National University of Singapore
    3. (6 articles) Singapore Eye Research Institute
    4. (5 articles) Johns Hopkins University
    5. (5 articles) David S. Friedman
    6. (4 articles) The Chinese University of Hong Kong
    7. (3 articles) University of Hong Kong
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    9. (2 articles) David Huang
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    Novel anterior-chamber angle measurements by high-definition optical coherence tomography using the Schwalbe line as the landmark Quantitative Assessment of Changes in Trabeculectomy Blebs After Laser Suture Lysis Using Anterior Segment Coherence Tomography Swept source optical coherence tomography measurement of the iris–trabecular contact (ITC) index: a new parameter for angle closure Analysis of Anterior Segment Dynamics Using Anterior Segment Optical Coherence Tomography Before and After Laser Peripheral Iridotomy Assessment of trabecular meshwork width using swept source optical coherence tomography Pretreatment Anterior Segment Imaging During Acute Primary Angle Closure: Insights into Angle Closure Mechanisms in the Acute Phase Profile and Determinants of Retinal Optical Intensity in Normal Eyes with Spectral Domain Optical ... Effect of optic disc–fovea distance on the normative classifications of macular inner retinal layers as assessed with OCT in healthy subjects Repeatability, reproducibility and agreement of foveal avascular zone measurements using three different optical coherence tomography angiography devices Subclinical hypothyroidism is associated with lipid-rich plaques in patients with coronary artery disease as assessed by optical coherence tomography Mitigation of Speckle Noise in Optical Coherence Tomograms Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography