1. Articles from carsten framme

    1-13 of 13
    1. Optical coherence tomography angiography analysis of macular flow density in glaucoma

      Optical coherence tomography angiography analysis of macular flow density in glaucoma

      Purpose Modifications in ocular blood flow may play a significant role in glaucoma development. Optical coherence tomography angiography (OCT‐A) is based on the detection and analysis of the reflection behaviour of motion in a static environment and therefore is able to quantify the retinal flow density. We used this new technology to examine the density of the active flow vasculature in the macular area in glaucoma patients compared to healthy patients. Methods Thirty patients with primary open‐angle glaucoma (mean age: 72.6 ± 7.1 years) and 21 healthy patients (mean age: 70.3 ± 8.6 years) were recruited ...

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      Mentions: Carsten Framme
    2. Intraoperative optical coherence tomography and ab interno trabecular meshwork surgery with the Trabectome

      Intraoperative optical coherence tomography and ab interno trabecular meshwork surgery with the Trabectome

      Importance: This study is the first description of the use of the intraoperative optical coherence tomography (iOCT) for trabecular meshwork surgery with the Trabectome in a regular clinical setting. Background: The aim of this study is to evaluate intraoperatively the immediate success of ab interno trabeculotomy with the Trabectome defined as a removal of the trabecular meshwork. Design: This is a retrospective clinical study performed in the University Eye Hospital, Medical School Hannover. Participants: A total of nine consecutive Caucasian patients suffering from primary open angle glaucoma, pigment dispersion glaucoma, or pseudoexfoliation glaucoma took part in the study. Methods: All ...

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    3. The short-term effects of aflibercept on the size of choroidal neovascularization lesion in treatment-resistant neovascular age-related macular degeneration as determined by spectral-domain optical coherence tomography

      The short-term effects of aflibercept on the size of choroidal neovascularization lesion in treatment-resistant neovascular age-related macular degeneration as determined by spectral-domain optical coherence tomography

      Background and Objectives To evaluate the changes in the size of choroidal neovascularization (CNV) lesion using spectral domain-optical coherence tomography (SD-OCT) in patients with treatment-resistant neovascular age-related macular degeneration (AMD) who were switched from ranibizumab to aflibercept. Materials and Methods In this prospective case-series, 33 eyes of 30 patients with treatment-resistant neovascular AMD were included. Treatment-resistant neovascular AMD was defined as choriodal neovascularization secondary to AMD determined by subretinal fluid and/or intraretinal fluid/cysts after more than 6 months of monthly ranibizumab therapy. Enrolled eyes were received intravitreal aflibercept injections at weeks 0, 4, and 8. Maximum area of ...

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    4. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial resolution of 1.78 μm was combined with an SRT system and time-resolved OCT M-scans of the target area were recorded from four patients undergoing SRT. Optical coherence tomography scans ...

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    5. Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Purpose: Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair. Methods: OCT scans of patients after successful macula-off RD repair were re-analyzed with a sub-segmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow up period after surgery of up to 7 weeks (range 21 to 49 days). In group 2 the follow up was > 8 weeks (range 60 to 438 days ...

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    6. Behavior of SD-OCT–Detected Hyperreflective Foci in the Retina of Anti-VEGF–Treated Patients with Diabetic Macular Edema

      Behavior of SD-OCT–Detected Hyperreflective Foci in the Retina of Anti-VEGF–Treated Patients with Diabetic Macular Edema

      Purpose. Hyperreflective foci (HFs) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). HFs have also been seen in wet age-related macular degeneration (AMD), although the origin is still unknown; however, they reduced significantly during anti-VEGF (vascular endothelial growth factor) therapy, and their baseline amount seemed to correlate with treatment success. In this study the behavior of HFs was evaluated during anti-VEGF therapy for DME. Methods. Fifty-one patients (mean age: 67 years) underwent SD-OCT before and one month after one anti-VEGF injection (ranibizumab: n = 30; bevacizumab: n = 21). The HFs were ...

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    7. Behaviour of SD-OCT detected hyperreflective foci in the retina of Anti-VEGF treated patients with Diabetic Macular Edema

      Behaviour of SD-OCT detected hyperreflective foci in the retina of Anti-VEGF treated patients with Diabetic Macular Edema

      Purpose:Hyperreflective foci (HF) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). The HF behaviour was evaluated during Anti-VEGF therapy in DME. Methods: Fifty-one patients (mean age: 67 years) underwent SD-OCT (Heidelberg engineering, Germany) before and one month after one Anti-VEGF injection (Ranibizumab: n=30; Bevacizumab: n=21). The amount of HFs were semi-quantitatively counted, assigned to 3 groups (A: SDPs n=1-10; B: n=11-20; C: n>20) and correlated to the course of visual acuity and foveal thickness (paired t-test). Additionally the baseline HbA1c was categorized and correlated ...

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    8. Small Dense Particles in the Retina Observable by Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration

      Small Dense Particles in the Retina Observable by Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration
      Purpose. To observe detailed changes in neurosensory retinal structure after anti-VEGF upload in age-related macular degeneration (AMD), by using spectral domain optical coherence tomography (SD-OCT). Methods. The retinal structure was observed by using SD-OCT in 61 patients, before and 1 month after the third ranibizumab injection (upload phase). The main focus of attention was a subjective determination of the amount and behavior of the numerous small, dense particles (SDPs) frequently observed within the outer and inner neurosensory layers in eyes with neovascular AMD. The Spearman rho correlation was used for statistical analysis. Results. In all eyes, various amounts of SDPs ...
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    9. Small dense particles within the neurosensory retinal layers observable by Spectral Domain Optical Coherence Tomography in Age-related macular Degeneration

      Small dense particles within the neurosensory retinal layers observable by Spectral Domain Optical Coherence Tomography in Age-related macular Degeneration
      Purpose: To observe detailed changes of neurosensory retinal structure after Anti VEGF upload in age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SD-OCT). Material and methods: The retinal structure was observed in 61 patients using the Spectralis-OCT (Heidelberg engineering, Germany) before and one months after third Ranibizumab injection (upload phase). The main focus of attention was subjectively laid on the amount and behaviour of the numerous small dense particles (SDP) frequently observable within the outer and inner neurosensory layers in eyes suffering from neovascular AMD. For statistical analysis the Spearmans Rho correlations were used (SPSS for Windows 16 ...
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    10. Effects on Choroidal Neovascularization after Anti-VEGF Upload Using Intravitreal Ranibizumab, as Determined by Spectral Domain-Optical Coherence Tomography

      Purpose. It is unclear whether anti-VEGF monotherapy in age-related macular degeneration (AMD) achieves morphologic CNV regression or only stops further CNV growth. In this study, spectral domain-optical coherence tomography (SD-OCT) was used to image CNV structure before and after anti-VEGF treatment. Methods. Out of 107 consecutive patients, a prospective CNV evaluation was possible in 78 of them. Newly diagnosed CNV (classic CNV: n = 16; occult CNV: n = 54; minimal classic CNV: n = 8) due to AMD was imaged before and 4 weeks after anti-VEGF upload in three intravitreal injections of ranibizumab. Qualitative (structural changes) and quantitative measurements (diameter and thickness ...
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    11. Structural changes of the retina after conventional laser photocoagulation and selective retina treatment (SRT) in spectral domain OCT.

      Background: Spectral domain optical coherence tomography (SD-OCT) in patients can deliver retinal cross-sectional images with high resolution. This may allow the evaluation of the extent of damage to the retinal pigment epithelium (RPE) and the neurosensory retina after laser treatment. This article aims to investigate the value of SD-OCT in comparing laser lesions produced by conventional laser photocoagulation and selective retina treatment (SRT). Material and Methods: In a retrospective study, conventional retinal laser (CRL) lesions and SRT laser lesions were evaluated with SD-OCT. One hundred seventy-five CRL lesions were investigated in 10 patients with diabetic maculopathy at timepoints between 1 ...

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    12. Effects on Choroidal Neovascularizations after Anti-VEGF Upload Using Intravitreal Ranibizumab as Determined by Spectral Domain Optical Coherence Tomography

      Purpose: To image CNV structure before and after anti-VEGF treatment using spectral domain optical coherence tomography (SD-OCT). Material and methods: In 78 patients newly diagnosed CNVs (classic CNV: n=16; occult CNV: n=54; minimal classic CNV: n=8) due to AMD were imaged before and 4 weeks after anti-VEGF upload with 3 intravitreal injections of Ranibizumab. Qualitative (structural changes) and quantitative measurements (diameter and thickness) of the CNVs were obtained from the OCT images using the Heidelberg Eye Explorer software. Results: Classic CNV components were observed above the RPE/photoreceptor complex, whereas occult CNVs stayed below. Qualitatively, overall CNV ...
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    13. Retreatment of full-thickness macular hole: predictive value of optical coherence tomography

      Aim: To determine whether the efficacy of re-operation for idiopathic full-thickness macular hole (FTMH) remaining open after initial surgery with internal limiting membrane (ILM) peeling is correlated with macular hole configuration as determined by optical coherence tomography (OCT), macular hole size, macular hole duration before the first operation, or type of tamponade (gas or silicone oil). Methods: A retrospective consecutive interventional case series of 28 patients (28 eyes) with a persisting macular hole after vitrectomy, ILM peel, and gas tamponade. 28 patients underwent repeat surgery involving vitrectomy and gas (n = 15) or silicone oil tamponade (n = 12) or no tamponade ...
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      Mentions: Carsten Framme
    1-13 of 13
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    1. (13 articles) Carsten Framme
    2. (6 articles) University of Bern
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    Small dense particles within the neurosensory retinal layers observable by Spectral Domain Optical Coherence Tomography in Age-related macular Degeneration Small Dense Particles in the Retina Observable by Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration Behaviour of SD-OCT detected hyperreflective foci in the retina of Anti-VEGF treated patients with Diabetic Macular Edema Behavior of SD-OCT–Detected Hyperreflective Foci in the Retina of Anti-VEGF–Treated Patients with Diabetic Macular Edema Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY Nonperfusion Assessment in Retinal Vein Occlusion: Comparison between Ultra-Widefield Fluorescein Angiography and Widefield OCT-Angiography Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics Repeatability and Reproducibility of Axial and Lateral Measurements on Handheld Optical Coherence Tomography Systems Compared with Tabletop System