1. Articles from johann roider

    1-7 of 7
    1. Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases

      Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases

      Purpose The treatment guidelines for many macular diseases rely on frequent monitoring with optical coherence tomography (OCT). However, the burden of frequent disease control leads to low therapy adherence in real life. OCT home monitoring would address this issue but requires an inexpensive and self-operable device. With self-examination low-cost full-field OCT (SELFF-OCT), our group has introduced a novel technology that may fulfill both requirements. In this pilot study, we report the initial experiences with a clinical prototype. Methods Fifty-one patients with different macular diseases were recruited in a cross-sectional study. The most common diseases were age-related macular degeneration (AMD; 39 ...

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    2. Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning

      Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning

      The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCTbased biomarkers. Therefore, the monitoring frequency has a significant influence on the success of AMD therapy. However, the monitoring frequency of current treatment schemes is not individually adapted to the patient and therefore often insufficient. While a higher monitoring frequency would have a positive effect on the success of treatment, in practice it can only be achieved with a home monitoring solution. One of the key requirements of a home monitoring ...

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    3. Comprehensive Detection, Grading, and Growth Behavior Evaluation of Subthreshold and Low Intensity Photocoagulation Lesions by Optical Coherence Tomographic and Infrared Image Analysis

      Comprehensive Detection, Grading, and Growth Behavior Evaluation of Subthreshold and Low Intensity Photocoagulation Lesions by Optical Coherence Tomographic and Infrared Image Analysis

      To correlate the long-term clinical effect of photocoagulation lesions after 6 months, as measured by their retinal damage size, to exposure parameters. We used optical coherence tomographic (OCT)-based lesion classes in order to detect and assess clinically invisible and mild lesions. Methods . In this prospective study, 488 photocoagulation lesions were imaged in 20 patients. We varied irradiation diameters (100/300 µm), exposure-times (20–200 ms), and power. Intensities were classified in OCT images after one hour, and we evaluated OCT and infrared (IR) images over six months after exposure. Results . For six consecutive OCT-based lesion classes, the following parameters ...

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    4. Calibration of histological retina specimens after fixation in Margo’s solution and paraffin embedding to in-vivo dimensions, using photography and optical coherence tomography

      Calibration of histological retina specimens after fixation in Margo’s solution and paraffin embedding to in-vivo dimensions, using photography and optical coherence tomography

      Background The extent of retinal tissue deformation by histological processing needs to be separately measured for every workup protocol. This work presents a simple approach for its quantitative assessment, and shows lateral and axial scaling factors for a common protocol. We calibrated histological measurements by in-vivo photographic and optical coherence tomographic (OCT) measurements, using retinal photocoagulation lesions as calibration markers. Methods We evaluated four rabbit eyes that were examined histologically after fixation in Margo’s solution (1 % paraformaldehyde:1.25 % glutaraldehyde), isopropanol dehydration, paraffin embedding and hematoxylin and eosin staining. Distances between 51 pairs of laser lesions were compared in ...

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    5. Photocoagulation in rabbits: Optical coherence tomographic lesion classification, wound healing reaction, and retinal temperatures

      Photocoagulation in rabbits: Optical coherence tomographic lesion classification, wound healing reaction, and retinal temperatures

      Background and Objective The rabbit is the most common animal model to study retinal photocoagulation lesions. We present a classification of retinal lesions from rabbits, that is based on optical coherence tomographic (OCT) findings, temperature data, and OCT-follow-up data over 3 months. Materials and Methods Four hundred eighty-six photocoagulation lesions (modified Zeiss Visulas® 532 nm CW laser, lesion diameter 133 µm, exposure duration 200 milliseconds or variable, power variable) were analyzed from six eyes of three chinchilla gray rabbits. During the irradiation of each lesion, we used an optoacoustics-based method to measure the retinal temperature profile. Two hours, 1 week ...

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    6. Correlation of temperature rise and optical coherence tomography characteristics in patient retinal photocoagulation

      Correlation of temperature rise and optical coherence tomography characteristics in patient retinal photocoagulation

      We conducted a study to correlate the retinal temperature rise during photocoagulation to the afterward detected tissue effect in optical coherence tomography (OCT). 504 photocoagulation lesions were examined in 20 patients. The retinal temperature increase was determined in real-time during treatment based on thermoelastic tissue expansion which was probed by repetitively applied ns laser pulses. The tissue effect was examined on fundus images and OCT images of individualized lesions. We discerned seven characteristic morphological OCT lesion classes. Their validity was confirmed by increasing visibility and diameters. Mean peak temperatures at the end of irradiation ranged from approx. 60 °C to ...

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    7. Retreatment of full-thickness macular hole: predictive value of optical coherence tomography

      Aim: To determine whether the efficacy of re-operation for idiopathic full-thickness macular hole (FTMH) remaining open after initial surgery with internal limiting membrane (ILM) peeling is correlated with macular hole configuration as determined by optical coherence tomography (OCT), macular hole size, macular hole duration before the first operation, or type of tamponade (gas or silicone oil). Methods: A retrospective consecutive interventional case series of 28 patients (28 eyes) with a persisting macular hole after vitrectomy, ILM peel, and gas tamponade. 28 patients underwent repeat surgery involving vitrectomy and gas (n = 15) or silicone oil tamponade (n = 12) or no tamponade ...
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    1-7 of 7
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    Correlation of temperature rise and optical coherence tomography characteristics in patient retinal photocoagulation Photocoagulation in rabbits: Optical coherence tomographic lesion classification, wound healing reaction, and retinal temperatures Calibration of histological retina specimens after fixation in Margo’s solution and paraffin embedding to in-vivo dimensions, using photography and optical coherence tomography Comprehensive Detection, Grading, and Growth Behavior Evaluation of Subthreshold and Low Intensity Photocoagulation Lesions by Optical Coherence Tomographic and Infrared Image Analysis Segmentation of Retinal Low-Cost Optical Coherence Tomography Images using Deep Learning Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography Depth of focus extension in optical coherence tomography using ultrahigh chromatic dispersion of zinc selenide Retinal changes in bipolar disorder as an endophenotype candidate: Comparison of OCT-detected retinal changes in patients, siblings, and healthy controls Intraoperative optical coherence tomography guided 25G micro-amount trajectory vitrectomy for the treatment of penetrating ocular injury caused by a foreign body in the right eye: A case study Optical coherence tomography angiography reveals paradoxically decreasing choroidal thickness & increasing blood flow in remitting Vogt Koyanagi Harada syndrome