1. Articles from constance r. chu

    1-5 of 5
    1. Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH)

      Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH)
      This report summarizes the 2010 AOSSM/NIH (American Orthopaedic Society for Sports Medicine/National Institutes of Health) U13 Post–Joint Injury Osteoarthritis II Conference to include the discussion concerning potential study cohorts, assessment considerations, and research priorities. There was strong consensus and enthusiasm for approaching the development of disease-modifying treatments for osteoarthritis through study of “pre-osteoarthritic” cohorts, particularly human subjects under 30 years of age following acute anterior cruciate ligament injuries. Clinical study of acute treatment strategies initiated within a few days after injury will need development of recruitment pathways and short-term proof-of-concept outcome measures that are specific to the ...
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    2. Arthroscopic Optical Coherence Tomography in Diagnosis of Early Arthritis

      Arthroscopic Optical Coherence Tomography in Diagnosis of Early Arthritis
      Osteoarthritis (OA) is a progressive, debilitating disease that is increasing in prevalence. The pathogenesis of OA is likely multifactorial but ultimately leads to progressive breakdown of collagen matrix and loss of chondrocytes. Current clinical modalities employed to evaluate cartilage health and diagnose osteoarthritis in orthopaedic surgery include, radiography, MRI, and arthroscopy. While these assessment methods can show cartilage fissuring and loss, they are limited in ability to diagnose cartilage injury and degeneration prior breakdown of the articular surface. An improved clinical ability to detect subsurface cartilage pathology is important for development and testing of chondroprotective and chondrorestorative treatments because the ...
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    3. Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears

      Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears
      Objective: Quantitative and nondestructive methods for clinical diagnosis and staging of articular cartilage degeneration are important to evaluation of potential disease modifying treatments for osteoarthritis. Optical Coherence Tomography (OCT) is a novel imaging technology that can generate microscopic resolution cross-sectional images of articular cartilage in near real time. This study tests the hypotheses that OCT can be used clinically to identify early cartilage degeneration, and that OCT correlates with MRI T2 values and arthroscopy. Methods: Patients undergoing arthroscopy for degenerative meniscal tears were recruited under IRB approved protocols. 30 consecutive subjects completing preoperative 3.0T MRI, arthroscopy, and intraoperative OCT ...
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    4. Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content

      Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content
      Optical coherence tomography (OCT) and T2 mapping are emerging clinical imaging technologies with potential to detect subsurface changes in cartilage retaining a macroscopically intact articular surface. This study tests the hypothesis that OCT correlates with magnetic resonance imaging (MRI) T2 values, and that OCT signal is sensitive to cartilage matrix degeneration. Forty-five osteochondral cores were harvested from five human tibial plateau explants after MRI T2 mapping. Cores underwent OCT imaging and were graded as follows: A, obvious birefringence; B, no birefringence; C, subsurface voids and/or irregular surface. Extracellular matrix content was determined and cores underwent histologic and polarized light ...
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    5. Clinical diagnosis of potentially treatable early articular cartilage degeneration using optical coherence tomography

      Constance R. Chu, Nicholas J. Izzo, James J. Irrgang et al. A series of bench to operating room studies was conducted to determine whether it is feasible to use optical coherence tomography (OCT) clinically to diagnose potentially reversible early cartilage degeneration. A human cadaver study was performed to confirm the reproducibility of OCT imaging and gr ... [J. Biomed. Opt. 12, 051703 (2007)] published Fri Oct 19, 2007.
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    1-5 of 5
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    1. (5 articles) University of Pittsburgh
    2. (5 articles) Constance R. Chu
    3. (1 articles) University of Iowa
    4. (1 articles) Vanderbilt University
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    Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears Arthroscopic Optical Coherence Tomography in Diagnosis of Early Arthritis Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH) Postdoctoral Associate Position at Duke Vision and Image Processing Laborator Anterior segment optical coherence tomography angiography Refining percutaneous coronary intervention: intracoronary imaging, haemodynamics, P2Y12 antagonists, and public outcomes reporting Optical Coherence Tomography/Fluorescence Imaging: Fiber assembly enables efficient multimodal endoscopy Optical Fabrication: Glassblowing technique creates arrays of axicon lenses University of Alabama Receives NIH Grant  for Clinical and Translational Core. University of Alabama Receives NIH Grant for Cell Model Evaluation Core. Changes in Posterior Segment Optical Coherence Tomography after Intravitreal Triamcinolone Acetonide Injection