1. Articles from Chui Ming Gemmy Cheung

    1-12 of 12
    1. Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements

      Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements

      We evaluated automated OCT-derived drusen volume measures in a population-based study (n = 4,512) aged ≥40 years, and its correlation with conventional color fundus photographs (CFP)-derived early AMD features. Participants had protocol-based assessment to capture medical and ocular history, genotyping for SNPs in CFH , ARMS2 , and CETP , CFP-based AMD grading and automated drusen volume based on SD-OCT using built-in software (Cirrus OCT advanced RPE analysis software). Significantly fewer eyes with early AMD features (drusen, hyperpigmentation, soft or reticular drusen) had drusen volume = 0 mm 3 (p < 0.001). In eyes with drusen volume > 0 mm 3 , increasing AMD severity ...

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    2. Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy

      Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy

      Purpose: To compare changes in optical coherence tomography angiography in eyes with polypoidal choroidal vasculopathy after treatment with anti–vascular endothelial growth factor monotherapy or combined with photodynamic therapy . Methods: This is a longitudinal case-controlled study. The authors performed optical coherence tomography angiography at baseline and Month 3 in patients with treatment-naive polypoidal choroidal vasculopathy undergoing monotherapy (n = 10) or combination therapy (n = 13). We analyzed flow signal within the outer retina and choriocapillaris using automated segmentation. The authors analyzed the presence of pachyvessels using a 10.4- μ m segment through Haller layer . The changes in each layer were compared ...

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    3. IMPROVED DETECTION AND DIAGNOSIS OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING A COMBINATION OF OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      IMPROVED DETECTION AND DIAGNOSIS OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING A COMBINATION OF OPTICAL COHERENCE TOMOGRAPHY AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To assess the ability of optical coherence tomography (OCT) alone and in combination with OCT angiography (OCTA) to differentiate polypoidal choroidal vasculopathy (PCV) from neovascular age-related macular degeneration , as compared to fluorescein angiography and indocyanine green angiography. Methods: This is a cross-sectional study. All participants had a standardized history, clinical examination including measurement of best-corrected visual acuity, slit-lamp biomicroscopy, and indirect fundus examination, and underwent standardized imaging (color photography, fluorescein and indocyanine green angiography, OCT, and OCTA) after predefined protocols. We used a 2-step approach (Step 1: spectral domain OCT; Step 2: addition of OCTA) combining structural OCT and ...

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    4. Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?

      Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?

      Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the 2 advanced stages of diabetic retinopathy (DR) that are the main causes for visual loss in patients with diabetes. Both DME and PDR can be readily diagnosed with clinical examination and, increasingly, by the noninvasive use of optical coherence tomography. However, another, less commonly recognized cause of visual loss in patients with diabetes is diabetic macular ischemia (DMI) in the absence of DME. 1 The understanding of the natural history, risk factors, and functional outcomes of DMI remains limited. This is partly because of the long-standing need for invasive ...

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    5. Optical coherence tomography angiography: a review of current and future clinical applications

      Optical coherence tomography angiography: a review of current and future clinical applications

      Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the caveats to the interpretation of images. As current optical coherence tomography angiography systems are optimized for the retina, most studies have focused on interpreting images from conditions such as age ...

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    6. COMPARISON OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHIC CHANGES AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY ALONE OR IN COMBINATION WITH PHOTODYNAMIC THERAPY IN POLYPOIDAL CHOROIDAL VASCULOPATHY

      COMPARISON OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHIC CHANGES AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY ALONE OR IN COMBINATION WITH PHOTODYNAMIC THERAPY IN POLYPOIDAL CHOROIDAL VASCULOPATHY

      Purpose: To compare changes in optical coherence tomography angiography in eyes with polypoidal choroidal vasculopathy after treatment with anti-vascular endothelial growth factor monotherapy or combined with photodynamic therapy. Methods: This is a longitudinal case-controlled study. The authors performed optical coherence tomography angiography at baseline and Month 3 in patients with treatment-naive polypoidal choroidal vasculopathy undergoing monotherapy (n = 10) or combination therapy (n = 13). We analyzed flow signal within the outer retina and choriocapillaris using automated segmentation. The authors analyzed the presence of pachyvessels using a 10.4-[mu]m segment through Haller layer. The changes in each layer were compared ...

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    7. A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration

      A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration

      Purpose: To evaluate choroidal structural changes in exudative age-related macular degeneration (AMD) using choroidal vascularity index computed from image binarization on spectral domain optical coherence tomography with enhanced depth imaging. Methods: This prospective case series included 42 consecutive patients with unilateral exudative AMD. Choroidal images were segmented into luminal area and stromal area. Choroidal vascularity index was defined as the ratio of luminal area to total choroid area. Mean choroidal vascularity index and mean choroidal thickness between study and fellow eyes of the same patient with dry AMD were compared using Student's t -test. Results: There was a significantly ...

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    8. Detailed Phenotyping and Characterization of Choroidal Morphological and Vascular Features in Young Men with High Myopia Using Spectral-Domain Optical Coherence Tomography

      Detailed Phenotyping and Characterization of Choroidal Morphological and Vascular Features in Young Men with High Myopia Using Spectral-Domain Optical Coherence Tomography

      Purpose To describe detailed morphological and vascular features of the choroid in eyes with high myopia. Design Cross-sectional study. Methods 515 eyes of young men (mean age 21.59±1.15) years) with high myopia (defined as -6.0 D or worse, mean spherical equivalent -8.66±2.00 D) and 88 controls with emmetropia in both eyes underwent choroidal imaging using spectral domain optical coherence tomography with enhanced depth imaging (EDI-OCT). Raw OCT images were loaded on a custom-written application on MATLAB that enabled delineation for detailed morphological and vascular analyses, including the distance of thickest point from the ...

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    9. CHARACTERIZATION AND DIFFERENTIATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      CHARACTERIZATION AND DIFFERENTIATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      Purpose: To determine the correlation and agreement between swept-source optical coherence tomography angiography (SS-OCT-A) with fluorescein angiography (FA), indocyanine green angiography (ICGA) and spectral domain OCT (SD-OCT) in characterizing polypoidal choroidal vasculopathy (PCV) and in differentiating eyes with typical age-related macular degeneration (t-AMD). Methods: This study included 32 and 54 eyes with t-AMD and PCV, respectively, who underwent SS-OCT-A, SD-OCT, fluorescein angiography, and indocyanine green angiography. The images from these four techniques were compared. Results: On SS-OCT-A, flow signals with vascular network configuration were detected in 81.2% and 77.8% of eyes with t-AMD and PCV, respectively. 40.4 ...

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      Mentions: Tien Yin Wong
    10. CHOROIDAL VASCULARITY INDEX: A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration

      CHOROIDAL VASCULARITY INDEX: A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration

      Purpose: To evaluate choroidal structural changes in exudative age-related macular degeneration (AMD) using choroidal vascularity index computed from image binarization on spectral domain optical coherence tomography with enhanced depth imaging. Methods: This prospective case series included 42 consecutive patients with unilateral exudative AMD. Choroidal images were segmented into luminal area and stromal area. Choroidal vascularity index was defined as the ratio of luminal area to total choroid area. Mean choroidal vascularity index and mean choroidal thickness between study and fellow eyes of the same patient with dry AMD were compared using Student's t-test. Results: There was a significantly lower ...

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    11. Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography

      Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography

      Purpose To assess the visibility of the choroidal–scleral interface (CSI) from spectral domain optical coherence tomography (SD-OCT) and evaluate the ocular and systemic factors influencing the visibility of CSI in healthy eyes from population-based Malay sample. Methods Participants were consecutively recruited from the population-based Singapore Malay Eye Study-2 (SiMES-2). SD-OCT images were obtained by Spectralis OCT with enhanced depth imaging (EDI) mode. Visibility of CSI was assessed by a grading system ranging from 0 to 2 scores. The reliability of choroidal thickness measurement in different grades of CSI visibility was assessed using intraclass correlation coefficient. Ordinal regression analyses were ...

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    12. Photoreceptor Changes in Acute and Resolved Acute Posterior Multifocal Placoid Pigment Epitheliopathy Documented by Spectral-Domain Optical Coherence Tomography

      Photoreceptor Changes in Acute and Resolved Acute Posterior Multifocal Placoid Pigment Epitheliopathy Documented by Spectral-Domain Optical Coherence Tomography
      . Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is generally believed to be a self-limiting inflammatory disorder affecting the retinal pigment epithelium (RPE). Vision usually recovers within weeks. The exact cause and site of the pathologic abnormality are not confirmed. We describe spectral-domain (SD) optical coherence tomography (OCT) cha
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    1-12 of 12
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    1. (9 articles) Singapore Eye Research Institute
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    Photoreceptor Changes in Acute and Resolved Acute Posterior Multifocal Placoid Pigment Epitheliopathy Documented by Spectral-Domain Optical Coherence Tomography Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography CHOROIDAL VASCULARITY INDEX: A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration CHARACTERIZATION AND DIFFERENTIATION OF POLYPOIDAL CHOROIDAL VASCULOPATHY USING SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY Detailed Phenotyping and Characterization of Choroidal Morphological and Vascular Features in Young Men with High Myopia Using Spectral-Domain Optical Coherence Tomography A Novel Optical Coherence Tomography Based Parameter in Patients With Exudative Age-Related Macular Degeneration COMPARISON OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHIC CHANGES AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY ALONE OR IN COMBINATION WITH PHOTODYNAMIC THERAPY IN POLYPOIDAL CHOROIDAL VASCULOPATHY Optical coherence tomography angiography: a review of current and future clinical applications Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime? Correlation of Color Fundus Photograph Grading with Risks of Early Age-related Macular Degeneration by using Automated OCT-derived Drusen Measurements Optical coherence tomography angiography of foveal neovascularisation in proliferative diabetic retinopathy Treating port wine stain birthmarks using dynamic optical coherence tomography-guided setting