1. Articles from Wei Chen

    1-16 of 16
    1. Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye Study

      Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study: the Handan Eye Study

      Purpose To examine the normative profile of retinal nerve fibre layer (RNFL) thickness and ocular parameters based on spectral-domain optical coherence tomography (SD-OCT) and its associations with related parameters among the Chinese population. Methods This population-based cohort Handan Eye Study (HES) recruited participants aged≥30 years. All subjects underwent a standardised ophthalmic examination. Peripapillary RNFL thickness was obtained using SD-OCT. Mixed linear models were adopted to evaluate the correlation of RNFL thickness with ocular parameters as well as systemic factors. R V.3.6.1 software was used for statistical analysis. Results 3509 subjects (7024 eyes) with the average age ...

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    2. Decreased iris thickness on swept-source optical coherence tomography in patients with primary open-angle glaucoma

      Decreased iris thickness on swept-source optical coherence tomography in patients with primary open-angle glaucoma

      Purpose: To investigate the iris thickness (IT) of patients with primary open-angle glaucoma (POAG) and older adults using anterior segment swept-source optical coherence tomography (SS-OCT). Methods: In this comparative cross-sectional study, 154 participants were enrolled, including 40 patients with POAG and 114 healthy individuals. Nasal-angle SS-OCT images were analyzed using calipers to measure the thickness of the iris, including the anterior border layer, stromal, and pigmented epithelial layer, at 1 and 2 mm from the pupil edge. The relationship between IT and glaucoma severity was analyzed, and receiver operating characteristic curves were constructed to assess the ability of each IT ...

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    3. Optical coherence hyperspectral microscopy with a single supercontinuum light source

      Optical coherence hyperspectral microscopy with a single supercontinuum light source

      In the paper, we have developed an optical coherence hyperspectral microscopy with a single supercontinuum light source. The microscopy consists of optical coherence tomography (OCT) and hyperspectral imaging (HSI), which can visualize the structural and functional characteristics of biological tissues. The 500-700 nm band is selected for HSI and OCT imaging, where HSI enables imaging of oxygen saturation and hemoglobin (Hb) content, while OCT acquires structural characteristics to assess the morphology of biological tissues. The system performance of the optical coherence hyperspectral microscopy is verified by normal mice ears, and the practical applications of the microscopy is further performed in ...

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    4. Noise Reduction for SD-OCT Using a Structure-Preserving Domain Transfer Approach

      Noise Reduction for SD-OCT Using a Structure-Preserving Domain Transfer Approach

      Spectral-domain optical coherence tomography (SD-OCT) images inevitably suffer from multiplicative speckle noise caused by random interference. This study proposes an unsupervised domain adaptation approach for noise reduction by translating the SD-OCT to the corresponding high-quality enhanced depth imaging (EDI)-OCT. We propose a structure-persevered cycle-consistent generative adversarial network for unpaired image-to-image translation, which can be applied to imbalanced unpaired data, and can effectively preserve retinal details based on a structure-specific cross-domain description. It also imposes smoothness by penalizing the intensity variation of the low reflective region between consecutive slices. Our approach was tested on a local data set that consisted ...

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    5. Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers

      Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers

      We developed a novel technology capable of detecting early-stage pancreatic cancers using high-resolution three-dimensional endoscopic optical coherence tomography (Endo-OCT), and treating them using high dose rate brachytherapy (HDR) under the Endo-OCT image guidance. This technology integrates our custom-built ultra-high resolution endoscopic three-dimensional OCT diagnostic imaging device with a commercial high dose rate brachytherapy system (HDR), resulting in a compact, portable, easy-to-operate, and low-cost Endo-OCT image-guided high dose rate brachytherapy (OCT-IGHDR) system. The system has the dual functions of diagnosis and treatment that can precisely detect and measure the location and size of the early-stage pancreatic cancer or premalignant lesions and ...

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    6. The 360° circumferential opening of Schlemm's canal in normal individuals detected by enhanced depth imaging optical coherence tomography

      The 360° circumferential opening of Schlemm's canal in normal individuals detected by enhanced depth imaging optical coherence tomography

      We aimed to observe the opening status and morphological parameters of Schlemm's canal (SC) in normal eyes using enhanced depth imaging optical coherence tomography (EDI-OCT). Consecutive EDI-OCT scans were used to examine the right eye of 20 normal individuals . EDI-OCT was performed clockwise for 8 regions (at the 12:00, 1:30, 3:00, 4:30, 6:00, 7:30, 9:00 and 10:30 o’clock positions). Image processing and analysis in java software was used to measure the area, perimeter, and diameter of SC. Twenty-one serial scans of each region were evaluated and a total of 168 ...

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    7. Quantitative evaluation of primary retinitis pigmentosa patients using colour Doppler flow imaging and optical coherence tomography angiography

      Quantitative evaluation of primary retinitis pigmentosa patients using colour Doppler flow imaging and optical coherence tomography angiography

      Purpose To find the potential relation between changes in retinal large vessels and terminal vessels using colour Doppler flow imaging (CDFI) and optical coherence tomography angiography (OCTA) and to compare the respective advantages of CDFI and OCTA in evaluating vascular changes in retinitis pigmentosa (RP) patients. Methods A prospective series of case study was conducted to enrol RP patients and age‐matched controls, who were, respectively, imaged by CDFI and OCTA. Repeatability and reproducibility of both CDFI and OCTA were performed among healthy volunteers. The central retinal artery (CRA) was detected by CDFI analysis to provide parameters of peak systolic ...

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    8. Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma

      The current gold standard for the clinical diagnosis of melanoma is excisional biopsy and histopathologic analysis. Approximately 15-30 benign lesions are biopsied to diagnose each melanoma. Additionally, biopsies are invasive and result in pain, anxiety, scarring and disfigurement of patients which can add an additional burden to the health care system. Among several imaging techniques developed to enhance melanoma diagnosis, optical coherence tomography (OCT), with its high-resolution and intermediate penetration depth, can potentially provide required diagnostic information noninvasively. Here we present an image analysis algorithm, 'optical properties extraction (OPE)', that improves the specificity and sensitivity of OCT by identifying unique ...

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    9. Cerebral capillary flow imaging by wavelength‐division‐multiplexing swept‐source optical Doppler tomography

      Cerebral capillary flow imaging by wavelength‐division‐multiplexing swept‐source optical Doppler tomography

      Swept‐source optical coherence tomography has demonstrated the unique advantages for fast imaging rate and long imaging distance, however, limited axial resolution and complex phase noises restrict swept‐source optical coherence Doppler tomography (SS‐ODT) for quantitative capillary blood flow imaging in the deep cortices. Here, the wavelength‐division‐multiplexing optical Doppler tomography (WDM‐ODT) method, which divides a single interferogram into multiple phase‐correlated interferograms, is proposed to effectively enhance the sensitivity for cerebral capillary flow imaging. Both flow phantom and in vivo mouse brain imaging studies show that WDM‐ODT is able to significantly suppress background phase noise ...

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    10. The use of optical coherence tomography to analyze the efficacy of skin care products

      The use of optical coherence tomography to analyze the efficacy of skin care products

      In this study, we assess the applicability of optical coherence tomography (OCT) for non-invasive imaging of skin morphology for the assessment of efficacy of cosmetic skin wrinkle-reduction products in humans. Evaluation of skin care products for reduction of facial wrinkles is largely limited to photographic (non-quantitative) comparison of skin surface texture before and after either single or prolonged application of skin care product. OCT could be a technique for monitoring changes in cross-sectional skin morphology. An optical attenuation coefficient analysis is also carried out to quantitatively study the changes in different layers of the skin.

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    11. High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging

      High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging

      Noninvasive microvascular imaging using optical coherence Doppler tomography (ODT) has shown great promise in brain studies; however, high-speed microcirculatory imaging in deep brain remains an open quest. A high-speed 1.3 μm swept-source ODT (SS-ODT) system is reported which was based on a 200 kHz vertical-cavity-surface-emitting laser. Phase errors induced by sweep-trigger desynchronization were effectively reduced by spectral phase encoding and instantaneous correlation among the A-scans. Phantom studies have revealed a significant reduction in phase noise, thus an enhancement of minimally detectable flow down to 268.2 μm/s. Further in vivo validation was performed, in which 3D cerebral-blood-flow (CBF ...

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    12. Impact of retinal pigment epithelium pathology on spectral-domain optical coherence tomography-derived macular thickness and volume metrics and their intersession repeatability

      Impact of retinal pigment epithelium pathology on spectral-domain optical coherence tomography-derived macular thickness and volume metrics and their intersession repeatability

      Background To determine the impact of retinal pigment epithelium (RPE) pathology on intersession repeatability of retinal thickness and volume metrics derived from Spectralis spectral-domain optical coherence tomography (SD-OCT). Design Prospective cross-sectional single centre study. Participants 56 eyes of 56 subjects were divided into 3 groups: (A) normal RPE band (25 eyes), (B) RPE elevation: macular soft drusen (13 eyes) and (C) RPE attenuation: geographic atrophy or inherited retinal diseases (18 eyes). Methods Each subject underwent three consecutive follow-up macular raster scans (61 B-scans at 119 micron separation) at 1-month intervals. Main outcome measures Retinal thicknesses and volumes for each zone ...

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    13. Coronary Plaque Characterization Assessed by Optical Coherence Tomography and Plasma Trimethylamine-N-oxide Levels in Patients with Coronary Artery Disease

      Coronary Plaque Characterization Assessed by Optical Coherence Tomography and Plasma Trimethylamine-N-oxide Levels in Patients with Coronary Artery Disease

      Optical coherence tomography (OCT) has been considered as the ideal tool for the evaluation of atherosclerotic plaques. Circulating trimethylamine-N-oxide (TMAO), which is a metabolite of the dietary lipid phosphatidylcholine, has recently been linked to elevated coronary artery disease (CAD) risk. The objective of the study was to investigate the relationship between circulating TMAO level and coronary plaque vulnerability assessed by OCT in CAD patients. A total of 26 patients with CAD were recruited to assess coronary plaque using OCT and measure plasma TMAO level. According to plaque rupture status, patients were divided into plaque rupture group (n = 12) and non-plaque ...

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    14. Type D Personality and Coronary Plaque Vulnerability in Patients With Coronary Artery Disease: An Optical Coherence Tomography Study

      Type D Personality and Coronary Plaque Vulnerability in Patients With Coronary Artery Disease: An Optical Coherence Tomography Study

      Objective: To investigate the association between Type D personality and higher incidence of major adverse cardiac events, we used in vivo optical coherence tomography (OCT) to evaluate the association between Type D with coronary plaque characteristics. Methods: A total of 109 patients who had culprit coronary plaque (s) were included in the study. The Type D construct was analyzed using both the categorized and the continuous approaches. Plaque vulnerability of culprit lesions was measured by OCT. Results: After adjusting for demographic and clinical factors, multivariate analysis demonstrated that Type D was associated with lipid plaque (odds ratio [OR] = 4.87 ...

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    15. Histological validation of frequency domain optical coherence tomography for the evaluation of neointimal formation after a novel polymer-free sirolimus-eluting stent implantation

      Histological validation of frequency domain optical coherence tomography for the evaluation of neointimal formation after a novel polymer-free sirolimus-eluting stent implantation

      Novel polymer-free drug-eluting stents have been developed to reduce polymer-related adverse events. However, neointimal coverage after polymer-free DES implantation is unclear and validation between optical coherence tomography (OCT) and histology is required. Sixteen polymer-free sirolimus-eluting stents were randomly implanted into coronary arteries of 8 normal swine. OCT and histological measurement were conducted at 3 or 6 months after stent placement. For quantitative measures, lumen area, stent area, neointimal area and neointimal thickness were validated in every single OCT and histology matched cross-section. Moreover, for qualitative analysis, OCT signal patterns of neointimal tissue were classified as homogeneous, layered and heterogeneous patterns ...

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    16. Tear Dynamics and Corneal Confocal Microscopy of Subjects with Mild Self-Reported Office Dry Eye

      Tear Dynamics and Corneal Confocal Microscopy of Subjects with Mild Self-Reported Office Dry Eye
      Purpose To investigate changes in tear dynamics and corneal microstructure in mild self-reported office dry eye. Design Prospective laboratory investigation. Participants Twenty healthy office workers, 20 office workers with mild self-reported dry eye, and 20 office workers with moderate to severe dry eye as determined by the Ocular Surface Disease Index (OSDI). Methods Real-time anterior segment optical coherence tomography was used to obtain upper (UTMV), lower (LTMV), tear meniscus volumes. The total tear meniscus volume (TTMV) was the sum of the UTMV and LTMV. This was followed by measurement of noninvasive tear breakup time (NITBUT), fluorescein tear breakup time (FTBUT ...
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    1-16 of 16
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    1. (2 articles) Capital Medical University
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    Tear Dynamics and Corneal Confocal Microscopy of Subjects with Mild Self-Reported Office Dry Eye Histological validation of frequency domain optical coherence tomography for the evaluation of neointimal formation after a novel polymer-free sirolimus-eluting stent implantation Type D Personality and Coronary Plaque Vulnerability in Patients With Coronary Artery Disease: An Optical Coherence Tomography Study Coronary Plaque Characterization Assessed by Optical Coherence Tomography and Plasma Trimethylamine-N-oxide Levels in Patients with Coronary Artery Disease Impact of retinal pigment epithelium pathology on spectral-domain optical coherence tomography-derived macular thickness and volume metrics and their intersession repeatability High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging Cerebral capillary flow imaging by wavelength‐division‐multiplexing swept‐source optical Doppler tomography Optical Radiomic Signatures Derived from Optical Coherence Tomography Images to Improve Identification of Melanoma Quantitative evaluation of primary retinitis pigmentosa patients using colour Doppler flow imaging and optical coherence tomography angiography Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography