1. Articles from Ute Wolf-Schnurrbusch

    1-8 of 8
    1. Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT

      Purpose: Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair. Methods: OCT scans of patients after successful macula-off RD repair were re-analyzed with a sub-segmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow up period after surgery of up to 7 weeks (range 21 to 49 days). In group 2 the follow up was > 8 weeks (range 60 to 438 days ...

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    2. Feature Of The Week 11/8/12: University Of Bern Presents Methods for Multi-Surface Segmentation of OCT Images

      Feature Of The Week 11/8/12: University Of Bern Presents Methods for Multi-Surface Segmentation of OCT Images

      Over the past several years and for the foreseeable future, development and implementation of algorithms for processing of OCT images has become a fertile area for researchers at universities and product development engineers at OCT system companies. Such algorithms can dramatically improve OCT images and extract new information, both of which can improve clinical decision making and add tremendous value and differentiation to a product line. Topical areas include removing motion artifacts from 3D data sets, fast processing and rendering of very large data sets, extracting functional information, registration of data sets from longitudinal studies, and more. Recently the University ...

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    3. Graph-Based Multi-Surface Segmentation of OCT Data Using Trained Hard and Soft Constraints

      Graph-Based Multi-Surface Segmentation of OCT Data Using Trained Hard and Soft Constraints

      Optical Coherence Tomography is a well established image modality in ophthalmology and used daily in the clinic. Automatic evaluation of such datasets requires an accurate segmentation of the retinal cell layers. However, due to the naturally low signal to noise ratio and the resulting bad image quality, this task remains challenging. We propose an automatic graphbased multi-surface segmentation algorithm that internally uses soft constraints to add prior information from a learned model. This improves the accuracy of the segmentation and increase the robustness to noise. Furthermore, we show that the graph size can be greatly reduced by applying a smart ...

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    4. Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model

      Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model

      With improvements in acquisition speed and quality, the amount of medical image data to be screened by clinicians is starting to become challenging in the daily clinical practice. To quickly visualize and find abnormalities in medical images, we propose a new method combining segmentation algorithms with statistical shape models. A statistical shape model built from a healthy population will have a close fit in healthy regions. The model will however not fit to morphological abnormalities often present in the areas of pathologies. Using the residual fitting error of the statistical shape model, pathologies can be visualized very quickly. This idea ...

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    5. Behavior of SD-OCT–Detected Hyperreflective Foci in the Retina of Anti-VEGF–Treated Patients with Diabetic Macular Edema

      Behavior of SD-OCT–Detected Hyperreflective Foci in the Retina of Anti-VEGF–Treated Patients with Diabetic Macular Edema

      Purpose. Hyperreflective foci (HFs) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). HFs have also been seen in wet age-related macular degeneration (AMD), although the origin is still unknown; however, they reduced significantly during anti-VEGF (vascular endothelial growth factor) therapy, and their baseline amount seemed to correlate with treatment success. In this study the behavior of HFs was evaluated during anti-VEGF therapy for DME. Methods. Fifty-one patients (mean age: 67 years) underwent SD-OCT before and one month after one anti-VEGF injection (ranibizumab: n = 30; bevacizumab: n = 21). The HFs were ...

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    6. Behaviour of SD-OCT detected hyperreflective foci in the retina of Anti-VEGF treated patients with Diabetic Macular Edema

      Behaviour of SD-OCT detected hyperreflective foci in the retina of Anti-VEGF treated patients with Diabetic Macular Edema

      Purpose:Hyperreflective foci (HF) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). The HF behaviour was evaluated during Anti-VEGF therapy in DME. Methods: Fifty-one patients (mean age: 67 years) underwent SD-OCT (Heidelberg engineering, Germany) before and one month after one Anti-VEGF injection (Ranibizumab: n=30; Bevacizumab: n=21). The amount of HFs were semi-quantitatively counted, assigned to 3 groups (A: SDPs n=1-10; B: n=11-20; C: n>20) and correlated to the course of visual acuity and foveal thickness (paired t-test). Additionally the baseline HbA1c was categorized and correlated ...

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    7. Small Dense Particles in the Retina Observable by Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration

      Small Dense Particles in the Retina Observable by Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration
      Purpose. To observe detailed changes in neurosensory retinal structure after anti-VEGF upload in age-related macular degeneration (AMD), by using spectral domain optical coherence tomography (SD-OCT). Methods. The retinal structure was observed by using SD-OCT in 61 patients, before and 1 month after the third ranibizumab injection (upload phase). The main focus of attention was a subjective determination of the amount and behavior of the numerous small, dense particles (SDPs) frequently observed within the outer and inner neurosensory layers in eyes with neovascular AMD. The Spearman rho correlation was used for statistical analysis. Results. In all eyes, various amounts of SDPs ...
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    8. Spectral-Domain Optical Coherence Tomography Use in Macular Diseases: A Review

      Spectral-Domain Optical Coherence Tomography Use in Macular Diseases: A Review
      The introduction of spectral-domain optical coherence tomography (SD-OCT) has improved the clinical value for assessment of the eyes with macular disease. This article reviews the advances of SD-OCT for the diagnostic of various macular diseases. These include vitreomacular traction syndrome, cystoid macular edema/diabetic macular edema, epiretinal membranes, full-thickness macular holes, lamellar holes, pseudoholes, microholes, and schisis from myopia. Besides offering new insights into the pathogenesis of macular abnormalities, SD-OCT is a valuable tool for monitoring macular disease.
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    1-8 of 8
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  2. Topics in the News

    1. (8 articles) University of Bern
    2. (5 articles) Sebastian Wolf
    3. (4 articles) Bern University Hospital
    4. (4 articles) Pascal A. Dufour
    5. (4 articles) Carsten Framme
    6. (3 articles) Jens H. Kowal
    7. (3 articles) Hannan Abdillahi
    8. (3 articles) University of Washington
    9. (2 articles) Ruikang K. Wang
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    12. (1 articles) Heidelberg Engineering
    13. (1 articles) Tufts University
    14. (1 articles) Zhejiang University
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    16. (1 articles) Jay S. Duker
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    Spectral-Domain Optical Coherence Tomography Use in Macular Diseases: A Review Small Dense Particles in the Retina Observable by Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration Behaviour of SD-OCT detected hyperreflective foci in the retina of Anti-VEGF treated patients with Diabetic Macular Edema Behavior of SD-OCT–Detected Hyperreflective Foci in the Retina of Anti-VEGF–Treated Patients with Diabetic Macular Edema Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model Graph-Based Multi-Surface Segmentation of OCT Data Using Trained Hard and Soft Constraints Feature Of The Week 11/8/12: University Of Bern Presents Methods for Multi-Surface Segmentation of OCT Images Retinal Layer Measurements After Successful Macula-off Retinal Detachment Repair using OCT Impact of cardiometabolic factors on retinal vasculature: A 3x3, 6x6 and 8x8-mm optical coherence tomography angiography study Quantitative research on the interaction between cerebral edema and peripheral cerebral blood perfusion using swept-source optical coherence tomography Optical coherence tomography angiography measures blood pulsatile waveforms at variable tissue depths Optical coherence tomography angiography distortion correction in widefield montage images