1. Articles from Stuart L. Graham

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    1. Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

      Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance

      Article Authors Metrics Comments Media Coverage Abstract Introduction Methods Results Discussion Supporting information Acknowledgments References Reader Comments (0) Media Coverage (0) Figures Abstract Purpose The ganglion cell analysis (GCA) of the CIRRUS TM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma. Method A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. The ...

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    2. Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes

      Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes

      Purpose To assess the agreement between a Scheimpflug camera (Pentacam) and a combined Placido-optical coherence tomography device (Visante OMNI) in measuring corneal curvature, thickness and elevation values in normal and keratoconic eyes. Methods Corneal measurements of 110 normal eyes (one eye per subject) and 70 keratoconic eyes were obtained from both devices and compared. Agreement was determined using the Bland–Altman analysis 95% limits of agreement (LoA). Results The Pentacam measured significantly greater keratometry readings in the flattest (K1) and steepest meridians (K2) in normal and keratoconic eyes. The 95% LoA in normal eyes were −0.32 to 0.59 ...

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    3. Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

      Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

      Purpose Loss of retinal ganglion cells in in non-optic neuritis eyes of Multiple Sclerosis patients (MS-NON) has recently been demonstrated. However, the pathological basis of this loss at present is not clear. Therefore, the aim of the current study was to investigate associations of clinical (high and low contrast visual acuity) and electrophysiological (electroretinogram and multifocal Visual Evoked Potentials) measures of the visual pathway with neuronal and axonal loss of RGC in order to better understand the nature of this loss. Methods Sixty-two patients with relapsing remitting multiple sclerosis with no previous history of optic neuritis in at least one ...

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    4. Correlation of structural RNFL parameters and functional measures using HRT3 and Spectralis SD-OCT at different levels of glaucoma severity

      Correlation of structural RNFL parameters and functional measures using HRT3 and Spectralis SD-OCT at different levels of glaucoma severity

      Background:  To compare the structure/function relationship in glaucoma cases at different levels of severity, and with different disc sizes, between the Heidelberg Retinal Tomography (HRT3) and Spectralis Spectral Domain Optical Coherence Tomography (SD-OCT). Design:   Retrospective study of glaucoma patients attending a Sydney-based private practice. Participants:   169 eyes of 169 patients, with a clinical diagnosis of glaucoma. Methods:   Patients were divided on visual field criteria into early (MD>-4dB), moderate (-4dB

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    5. Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

      Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

      Purpose. Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (transsynaptic) mechanism of retinal damage in these diseases. In the present study we used optical coherence tomography to investigate retrograde retinal transsynaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. Methods. Fifteen eyes of glaucoma patients with visual field defect limited to upper hemifield and 15 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were ...

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    6. Trans-synaptic retinal degeneration in optic neuropathies: Optical Coherence Tomography study

      Trans-synaptic retinal degeneration in optic neuropathies: Optical Coherence Tomography study
      Purpose. Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (trans-synaptic) mechanism of retinal damage in these diseases. In the present study we used Optical Coherence Tomography to investigate retrograde retinal trans-synaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. Methods. Ten eyes of glaucoma patients with visual field defect limited to upper hemifield and 10 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were ...
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    7. Minimising retinal vessel artefacts in optical coherence tomography images

      Minimising retinal vessel artefacts in optical coherence tomography images

      Optical coherence tomography (OCT) is commonly used to investigate the layers of the retina including retinal nerve fiber layer (RNFL) and retinal pigment epithelium (RPE). OCT images are altered by vessels on the retinal surface producing artefacts. We propose a new approach to compensate for these artefacts and enhance quality of OCT images. A total of 28 (20 normal and 8 glaucoma subjects) OCT images were obtained using Spectralis (Heidelberg, Germany). Shadows were detected along the image and compensated by the A-Scan intensity difference from surrounding non-affected areas. Images were then segmented and the area and thickness of RNFL and ...

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    8. Interrelationship of Optical Coherence Tomography and Multifocal Visual-Evoked Potentials after Optic Neuritis

      Interrelationship of Optical Coherence Tomography and Multifocal Visual-Evoked Potentials after Optic Neuritis

      Purpose. Acute optic neuritis (ON) is often followed by recovery of visual function. Although this recovery is mainly attributable to resolution of the acute inflammation, the redistribution of ion channels along the demyelinated membrane, and subsequent remyelination, part of it may be the result of neural plasticity. In the present study, the interrelationship was examined between structural (retinal nerve fiber layer [RNFL] thickness) and functional (amplitude of multifocal visual evoked potentials [mfVEPs]) measures of the integrity of the visual pathway in the postacute stage of ON, to determine whether there was any evidence of ongoing neural reorganization. Methods. Twenty-five subjects ...

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    1-8 of 8
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    1. (7 articles) Stuart L. Graham
    2. (5 articles) University of Sydney
    3. (5 articles) Macquarie University
    4. (4 articles) Alexander Klistorner
    5. (2 articles) Heidelberg Engineering
    6. (1 articles) Carl Zeiss Meditec
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    Interrelationship of Optical Coherence Tomography and Multifocal Visual-Evoked Potentials after Optic Neuritis Minimising retinal vessel artefacts in optical coherence tomography images Trans-synaptic retinal degeneration in optic neuropathies: Optical Coherence Tomography study Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study Correlation of structural RNFL parameters and functional measures using HRT3 and Spectralis SD-OCT at different levels of glaucoma severity Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients Comparative analysis of corneal measurements obtained from a Scheimpflug camera and an integrated Placido-optical coherence tomography device in normal and keratoconic eyes Prevalence and type of artefact with spectral domain optical coherence tomography macular ganglion cell imaging in glaucoma surveillance Long-Term Arterial Remodeling After Bioresorbable Scaffold Implantation 4-Year Follow-up of Quantitative Coronary Angiography, Histology and Optical Coherence Tomography Visualization of Bacterial Colonization and Cellular Layers in a Gut-on-a-Chip System Using Optical Coherence Tomography Optical Coherence Tomography Measurements as Potential Imaging Biomarkers for Parkinson's Disease: A Systematic Review and Meta-analysis Use of ultra-wide field retinal imaging and optical coherence tomography angiography in the diagnosis of incomplete Susac syndrome