1. Articles from Chunhui Jiang

    1-23 of 23
    1. Microscope-integrated Intraoperative Optical Coherence Tomography for Anterior Segment Surgical Maneuvers

      Microscope-integrated Intraoperative Optical Coherence Tomography for Anterior Segment Surgical Maneuvers

      Purpose : To evaluate the potential value of microscope-integrated optical coherence tomography (MI-OCT) in anterior segment surgical maneuvers. Methods : Twenty-four ophthalmology residents, who were randomly and evenly divided into two groups, performed four anterior segment surgical maneuvers (corneal tunnel, scleral tunnel, simple corneal suture, and corneal laceration repair) on porcine eyes with (group B) or without (group A) real-time MI-OCT feedback. All residents performed the maneuvers again without MI-OCT. Results : Compared with group A, group B (with MI-OCT) showed better accuracy in the length/depth of the corneal tunnel and the length of the scleral tunnel. However, both groups showed similar ...

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    2. Relationship between photoreceptor layer changes before half-dose photodynamic therapy and functional and anatomic outcomes in central serous chorioretinopathy

      Relationship between photoreceptor layer changes before half-dose photodynamic therapy and functional and anatomic outcomes in central serous chorioretinopathy

      Objectives To investigate the relationship between photoreceptor layer (PRL) changes before half-dose photodynamic therapy (PDT) and functional and anatomic outcomes in central serous chorioretinopathy (CSC). Methods Baseline PRL changes were classified based on optical coherence tomography: (1) smooth PRL outer border without a foveal PRL defect; (2) smooth PRL outer border with a foveal PRL defect; (3) granulated PRL outer border and (4) scattered dots of PRL. The best-corrected visual acuity (BCVA), difference in the foveal outer nuclear layer (ONL) thickness between the CSC and normal contralateral eyes and ellipsoid zone (EZ) integrity 12 months after half-dose PDT were compared ...

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    3. Changes in macular vasculature after uncomplicated phacoemulsification surgery: Optical coherence tomography angiography study

      Changes in macular vasculature after uncomplicated phacoemulsification surgery: Optical coherence tomography angiography study

      Purpose To use optical coherence tomography (OCT) angiography and a split-spectrum amplitude–decorrelation angiography algorithm to evaluate the changes in the macular vascular system after uncomplicated phacoemulsification. Setting Department of Ophthalmology, Eye and and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China. Design Prospective case series. Methods Patients with senile cataracts were included. Retinal vessel density and thickness at the macular area were checked by OCT at baseline and at 1 week, 1 month, and 3 months after cataract surgery. Results Thirty-two eyes (32 patients) were included in the final analysis. There was a significant increase in retinal ...

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      Mentions: Chunhui Jiang
    4. Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography

      Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography

      Purpose: To investigate the changes in the retinal vasculature in different parts of the fundus in eyes with primary angle closure glaucoma (PACG). Methods: Healthy subjects and those with PACG were enrolled. Optical coherence tomography and a split-spectrum amplitude decorrelation angiography algorithm were used to quantify the retinal vessel densities in the parafoveal and peripapillary areas. Results: Thirty-nine eyes from 24 PACG patients and 39 eyes from 20 age- and sex-matched healthy subjects were included. The retinal vessel densities in the parafoveal and peripapillary areas and every sector of the two areas were significantly lower in the PACG eyes than ...

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    5. Retinal Vascular Autoregulation during Phase IV of the Valsalva Maneuver: An Optical Coherence Tomography Angiography Study in Healthy Chinese Adults

      Retinal Vascular Autoregulation during Phase IV of the Valsalva Maneuver: An Optical Coherence Tomography Angiography Study in Healthy Chinese Adults

      The impairment of retinal vascular autoregulation can be an early manifestation of many systemic and ocular diseases. Therefore, quantifying retinal vascular autoregulation in a non-invasive manner is very important. This study evaluated the effects of a Valsalva maneuver (VM)-induced blood pressure increases on retinal vascular autoregulation. Parafoveal and peripapillary retinal vessel density were measured with optical coherence tomography angiography before (baseline) and 5 s after each subject completed a VM (Phase IV [VM-IV]). Hemodynamic parameters and intraocular pressure (IOP) were examined. Blood pressure (systolic, diastolic, and mean arterial) and ocular perfusion pressure significantly increased during VM-IV, but IOP and ...

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    6. Reduced Retinal Vessel Density in Obstructive Sleep Apnea Syndrome Patients: An Optical Coherence Tomography Angiography Study

      Reduced Retinal Vessel Density in Obstructive Sleep Apnea Syndrome Patients: An Optical Coherence Tomography Angiography Study

      Purpose : To examine the retinal vasculature in patients with obstructive sleep apnea–hypopnea syndrome (OSAS) and to determine the correlation between retinal vascularity and the severity of OSAS. Design : Prospective, cross-sectional study. Methods : Sixty-nine consecutive subjects who underwent polysomnography were enrolled. Patients were divided into three groups according to the severity of OSAS, which was defined using the apnea-hypopnea index (AHI) as normal-to-mild (AHI <15), moderate (≥15 to <30), or severe (≥30). The vessel densities, and macular and retinal nerve fiber layer thicknesses were compared among the three groups. The correlations between clinical variables (age, heart rate, body mass index ...

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    7. Peripapillary retinal vessel density in eyes with acute primary angle closure: an optical coherence tomography angiography study

      Peripapillary retinal vessel density in eyes with acute primary angle closure: an optical coherence tomography angiography study

      Purpose The purpose was to investigate peripapillary retinal vessel density in resolved acute primary angle closure (APAC) eyes. Methods This was a prospective, cross-sectional observational study. Thirty-four eyes of 34 patients with unilateral APAC were included, together with the fellow eyes with primary angle closure suspect (PACS) as controls. Peripapillary retinal vessel density was measured using optical coherence tomography (OCT) angiography. Peripapillary retinal vessel density was compared in both eyes and the potential relationship with visual field (VF) test results was evaluated. Results After an acute attack, the peripapillary retinal vessel density was lower in the APAC than in the ...

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      Mentions: Chunhui Jiang
    8. Schlemm's Canal Expansion After Uncomplicated Phacoemulsification Surgery: An Optical Coherence Tomography Study

      Schlemm's Canal Expansion After Uncomplicated Phacoemulsification Surgery: An Optical Coherence Tomography Study

      Purpose : To evaluate the effects of phacoemulsification cataract surgery on Schlemm's canal (SC) using swept-source optical coherence tomography (OCT). Methods : Patients with a senile cataract were included. The SC area and diameter were checked by OCT at the baseline and 1 day, 1 week, 1 month, and 6 months after the cataract surgery. Multivariate linear regression analysis was performed for predictors of change in the mean SC area and diameter. Results : Twenty-five eyes (25 patients) were included in the final analysis. After the cataract surgery, there was a significant increase in the SC area and diameter, and a decrease ...

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    9. Relationship Between Retinal Perfusion and Retinal Thickness in Healthy Subjects: An Optical Coherence Tomography Angiography Study

      Relationship Between Retinal Perfusion and Retinal Thickness in Healthy Subjects: An Optical Coherence Tomography Angiography Study

      Purpose : To investigate the relationship between retinal perfusion and retinal thickness in the peripapillary and macular areas of healthy subjects. Methods : Using spectral-domain optic coherence tomography and split-spectrum amplitude decorrelation angiography (SSADA) algorithm, retinal perfusion and retinal thicknesses in the macular and peripapillary areas were measured in healthy volunteers, and correlations among these variables were analyzed. Results : Overall, 64 subjects (121 eyes) including 28 males and 36 females with a mean ± SD age of 38 ± 13 years participated. Linear mixed-models showed that vessel area density was significantly correlated with the inner retinal thickness (from the inner limiting membrane to the ...

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    10. Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study

      Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study

      Purpose To explore how optic disc perfusion varies in patients with open-angle glaucoma (OAG) and how this correlates with glaucoma severity. Methods We performed a prospective and cross-sectional observational study that included 62 eyes from 62 patients with OAG, divided into three groups according to their visual field (VF) results, and 20 eyes from 20 normal control subjects. Optic disc perfusion was studied using optical coherence tomography angiography (angio-OCT), and flow index and vessel density were determined. The VF, mean deviation (MD), pattern standard deviation (PSD), retinal nerve fiber layer (RNFL) thickness, and ganglion cell complex (GCC) thickness were also ...

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    11. Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

      Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort

      Background To explore the changes in thickness in different areas and layers of the macula under different refractive conditions. Methods Consecutive participants were enrolled in the study. Optical coherence tomography (OCT) images were obtained using a spectral-domain system. We studied the relationships of the full, inner and outer retinal thicknesses of the fovea, parafovea and perifovea relative to the spherical equivalent (SE) and axial length (AL). Results We included 107 eyes; the analysis revealed that the men had thicker foveas (man vs women: 236.70 ± 18.97 μm vs 247.25 ± 16.70 μm P  = 0.002) and inner parafoveas ...

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    12. Correlation between Retinal Changes and Visual Function in Late-Stage Vogt-Koyanagi-Harada Disease: An Optical Coherence Tomography Study

      Correlation between Retinal Changes and Visual Function in Late-Stage Vogt-Koyanagi-Harada Disease: An Optical Coherence Tomography Study

      Purpose. To characterize the optical coherence tomography (OCT) findings in late-stage Vogt-Koyanagi-Harada (VKH) disease and its correlation with visual function. Methods. The records of patients with late-stage VKH disease (defined as ≥12 months from disease onset) were retrospectively reviewed. The analysis focused on the OCT findings and microperimetry, in addition to the possible correlation between morphology and functional findings. Results. Twenty-nine patients (58 eyes) were included. Mean age at onset was 34.24 ± 10.67 years. The OCT revealed that the outer retina and retinal pigment epithelium (RPE) were mainly affected. These effects included RPE thickening and breakage or disappearance ...

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    13. Macular Perfusion in Healthy Chinese: An Optical Coherence Tomography Angiogram Study

      Macular Perfusion in Healthy Chinese: An Optical Coherence Tomography Angiogram Study

      Purpose. To investigate macular perfusion in healthy Chinese individuals and examine its dependence on age and sex. Methods. Healthy adult Chinese individuals were recruited. Macular perfusion was measured by spectral-domain optical coherence tomography (OCT) using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. The parafoveal flow index and vessel area density as well as the area of the foveal capillary-free zone (CFZ) were quantified. Results. A total of 76 eyes in 45 subjects were included (20 males and 25 females, mean age 36 ± 11 years). The mean parafoveal flow index was 0.099 ± 0.013; the mean vessel area density was 0 ...

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    14. Optical Coherence Tomography Angiography of Peripapillary Retinal Blood Flow Response to Hyperoxia

      Optical Coherence Tomography Angiography of Peripapillary Retinal Blood Flow Response to Hyperoxia

      Purpose. To measure the change in peripapillary retinal blood flow in response to hyperoxia by using optical coherence tomography (OCT) angiography. Methods. One eye of each healthy human participants (six) was scanned with a commercial high-speed (70 kHz) spectral OCT. Scans were captured twice after 10-minute exposures to normal breathing (baseline) and hyperoxia. Blood flow was detected by the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. Peripapillary retinal blood flow index and vessel density were calculated from en face maximum projections of the retinal layers. The experiment was performed on 2 separate days for each participant. Coefficient of variation (CV) was used ...

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    15. Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma

      Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma

      Purpose: Using anterior chamber optical coherence tomography to evaluate changes in angle anatomy in patients with primary angle-closure glaucoma (PACG) before and after trabeculectomy. Methods: This is a prospective observational study in 38 eyes of 38 patients with PACG, who underwent trabeculectomy. We used customized software to analyze optical coherence tomography images (Visante) of all participants before and after the surgical treatment. Multivariate linear regression analysis was performed for predictors of percentage change in mean angle parameters, including scleral spur angle, angle opening distance, angle recess area, and trabecular-iris surface area. The main outcome measures were changes in angle parameters ...

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    16. Study of Sub-retinal Exudation and Consequent Changes in Acute Central Serous Chorioretinopathy by Optical Coherence Tomography

      Study of Sub-retinal Exudation and Consequent Changes in Acute Central Serous Chorioretinopathy by Optical Coherence Tomography

      Purpose To investigate the characteristics of sub-retinal exudation and consequent morphologic changes in acute central serous chorioretinopathy (CSC) using spectral domain optical coherence tomography (SD-OCT). Design Prospective, observational, cross-sectional case series. Methods CSC patients, with symptom duration of less than 3 months, underwent visual acuity measurement, fundus observation and SD-OCT exam, and then were evaluated sub-retinal exudation and other changes. Results A total of 123 patients (123 eyes) were included, all showing various retinal pigment epithelium (RPE) abnormalities on OCT. And also OCT showed sub-retinal exudation (65 eyes, 52.8%), retinal dipping (14 eyes, 11.4%) and photoreceptor layer defect ...

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    17. Clinical and optic coherence tomography findings of focal choroidal excavation in Chinese patients

      Clinical and optic coherence tomography findings of focal choroidal excavation in Chinese patients

      Background To describe the clinical and optical coherence tomography (OCT) features of focal choroidal excavation in Chinese patients. Methods Retrospectively, thirty-seven eyes (in 31 patients) that demonstrated focal choroidal excavation on spectral-domain OCT were collected. Their clinical characteristics and other features were also collected and analyzed. Results In total, 42 focal choroidal excavations were identified in 31 patients, including 25 unilateral and 6 bilateral (37 eyes). The abnormal changes in these eyes with choroidal excavation were more prominent at the outer part of the neuro-retina, the retinal pigment epithelium (RPE) and the choroid. The average transverse diameter and depth of ...

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    18. Effect of myopia on ganglion cell complex and peripapillary retinal nerve fiber layer measurements: a Fourier domain optical coherence tomography study of young Chinese persons

      Effect of myopia on ganglion cell complex and peripapillary retinal nerve fiber layer measurements: a Fourier domain optical coherence tomography study of young Chinese persons

      Background To investigate the change of the ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (RNFL) under different refractive conditions, as measured by optical coherence tomography (OCT). Design Cross-sectional observational study. Participants A total of 107 eyes from 107 subjects were studied. Methods GCC and RNFL were studied by a spectral domain system-RTVue OCT. Their relationship against spherical equivalents (SE) and axial length (AL) was studied. Main Outcome Measures The thickness of GCC and RNFL at different area and under different refractive conditions as measurements by OCT. Results The average, superior, and inferior macular GCC thickness was significantly ...

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    19. Comparison of Schlemm’s canal’s biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical coherence tomography

      Comparison of Schlemm’s canal’s biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical coherence tomography

      Thirty-seven normal and primary open angle glaucoma (POAG) subjects were noninvasively imaged by a tailor-made real-time anterior segment swept source optical coherence tomography (SS-OCT) to demonstrate the differences of the Schlemm’s canal (SC) between POAG and normal eyes. After the cross-section images of the anterior chamber angle were acquired by SS-OCT, SC was confirmed by two independent masked observers and the average area, long diameter, and perimeter of the SC were measured. In normal subjects the circumference, area, and long diameter is 580.34 ± 87.81     μ m , 8023.89 ± 1486.10     μ m 2 , and 272.83 ± 49.39     μ m ...

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    20. Study of Anterior Chamber Aqueous Tube Shunt by Fourier-Domain Optical Coherence Tomography

      Study of Anterior Chamber Aqueous Tube Shunt by Fourier-Domain Optical Coherence Tomography

      Purpose . This cross-sectional, observational study used Fourier-domain optical coherence tomography (OCT) to examine the position, patency, and the interior entrance site of anterior chamber (AC) aqueous tube shunts. Methods. The OCT, slitlamp biomicroscopy, and gonioscopy findings of 23 eyes of 18 patients with AC shunts were collected and compared. Results. OCT images demonstrated the shunt position and patency in all 23 eyes, and the details of the AC entrance in 16 eyes. The position of the tube varied, with the majority (14/23) on the surface of the iris. The exact position of the AC entrance relative to Schwalbe’s ...

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    21. Morphometric measurement of Schlemm’s canal in normal human eye using anterior segment swept source optical coherence tomography

      Morphometric measurement of Schlemm’s canal in normal human eye using anterior segment swept source optical coherence tomography

      We have used anterior segment swept source optical coherence tomography to measure Schlemm’s canal (SC) morphometric values in the living human eye. Fifty healthy volunteers with 100 normal eyes were measured in the nasal and temporal side. Comparison with the published SC morphometric values of histologic sections proves the reliability of our results. The statistical results show that there are no significant differences between nasal and temporal SC with respect to their diameter, perimeter, and area in our study (diameter: t = 0.122, p = 0.903; perimeter: t = −0.003, p = 0.998; area: t = −1.169, p = 0 ...

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    22. Optical Coherence Tomography for Evaluation of Photodynamic Therapy in Symptomatic Circumscribed Choroidal Hemangioma

      Optical Coherence Tomography for Evaluation of Photodynamic Therapy in Symptomatic Circumscribed Choroidal Hemangioma

      Purpose: To evaluate the results of photodynamic therapy for circumscribed choroidal hemangioma by optical coherence tomography. Methods: A retrospective review of 14 eyes with systematic circumscribed choroidal hemangioma receiving photodynamic therapy was evaluated by time-domain optical coherence tomography. Central retinal thickness and foveal photoreceptor layer thickness were assessed, including the status of the junction between the inner and the outer segments of the photoreceptors (IS/OS) in the fovea at the final examination. Results: The optical coherence tomography findings included 9 eyes (64.3%) with foveal cystoid edema, 9 eyes (64.3%) with subretinal fluid, and 1 eye (7.1 ...

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    23. Foveomacular Schisis in Juvenile X-Linked Retinoschisis: An Optical Coherence Tomography Study

      Foveomacular Schisis in Juvenile X-Linked Retinoschisis: An Optical Coherence Tomography Study

      Purpose: To explore the structural features of juvenile X-linked retinoschisis using spectral-domain optical coherence tomography (OCT).Design: Retrospective, observational cross-sectional study.Methods: Eighteen male patients (34 eyes) who were diagnosed with juvenile X-linked retinoschisis at the Eye & ENT Hospital of Fudan University over an 18-month period were included. Their OCT images, which were obtained using spectral-domain OCT (Cirrus HD-OCT; Carl Zeiss Meditec), were analyzed. The anatomic location of the schisis cavity in juvenile X-linked retinoschisis was characterized by direct inspection of OCT images.Results: On OCT, the schisis cavity was visible at the fovea in all 34 eyes, and it was associated with increased retinal thickness. Schisis was present at the retinal nerve fiber layer in 4 eyes, at the inner nuclear ...

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    1-23 of 23
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    Foveomacular Schisis in Juvenile X-Linked Retinoschisis: An Optical Coherence Tomography Study Optical Coherence Tomography for Evaluation of Photodynamic Therapy in Symptomatic Circumscribed Choroidal Hemangioma Morphometric measurement of Schlemm’s canal in normal human eye using anterior segment swept source optical coherence tomography Study of Anterior Chamber Aqueous Tube Shunt by Fourier-Domain Optical Coherence Tomography Comparison of Schlemm’s canal’s biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical coherence tomography Effect of myopia on ganglion cell complex and peripapillary retinal nerve fiber layer measurements: a Fourier domain optical coherence tomography study of young Chinese persons Clinical and optic coherence tomography findings of focal choroidal excavation in Chinese patients Study of Sub-retinal Exudation and Consequent Changes in Acute Central Serous Chorioretinopathy by Optical Coherence Tomography Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma Effects of myopia on different areas and layers of the macula: a fourier-domain optical coherence tomography study of a chinese cohort Evaluation of Age-related Skin Changes and Instrument Reliability Using Clinical Probe Measurements and Imaging Modalities HP-OCT™ wins Victorian AEEA award – nominated for Sir William Hudson award