1. Articles from andrew rollins

    1-15 of 15
    1. Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      An estimated 17.5 million people died from a cardiovascular disease in 2012, representing 31 percent of all global deaths. Most acute coronary events result from rupture of the protective fibrous cap overlying an atherosclerotic plaque. The task of early identification of plaque types that can potentially rupture is, therefore, of great importance. The state-of-the-art approach to imaging blood vessels is intravascular optical coherence tomography (IVOCT). However, currently, this is an offline approach where the images are first collected and then manually analyzed an image at a time to identify regions at risk of thrombosis. This process is extremely laborious ...

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    2. Gated optical coherence tomography (OCT)

      Gated optical coherence tomography (OCT)

      Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental ...

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    3. Segmentation and quantification for intravascular optical coherence tomography images

      Segmentation and quantification for intravascular optical coherence tomography images

      A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide wire, vessel wall, calcified plaques, fibrous caps, macrophages, metallic and bioresorbable stents are described, and including visualization of results. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies stenting. Volumetric segmentation and quantification of fibrous caps can provide more comprehensive information of the mechanisms behind plaque rupture. Quantification of macrophages can aid diagnosis and prediction of unstable plaque and associated acute coronary events. Automated detection and quantification of ...

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    4. Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia

      Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia

      Objective: The study aimed to determine if the difference in cervical epithelium brightness, as measured by optical coherence tomography (OCT), has potential as a distinguishing characteristic of normal, low-grade, high-grade (cervical intraepithelial neoplasia 2+), and cancer histological findings. Materials and Methods: Information from 476 women was available for analysis. Demographic information was collected through in-person interview. All participants were human papillomavirus positive and/or had abnormal cytological finding and underwent colposcopy or unaided visual inspection and examination by OCT by quadrant. All women had a minimum of 4 OCT-matched cervical biopsies and endocervical curettage. Two sample t tests were used ...

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    5. OCT News 2013 Student Paper Awarded to Pei Ma from Case Western Reserve University

      OCT News 2013 Student Paper Awarded to Pei Ma from Case Western Reserve University

      Pei Ma from Case Western Reserve University was a winner of the 2013 OCT News Student Paper Award for her submission “Developing Technologies for Electrophysiology Imaging in Embryonic Hearts.” Below is a summary of her work: Abstract: Congenital heart defects (CHDs) are one of the most common and devastating birth defects. Abnormal electrical activity at early stage of heart development can lead to severe CHDs. However, most developmental cardiology studies have not addressed the influential role of electrical activity in CHD etiology due to difficulties in early stages such as the embryonic hearts being too fragile for electrode recording, signal ...

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    6. Gated optical coherence tomography (OCT) environmental chamber

      Gated optical coherence tomography (OCT) environmental chamber

      Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental ...

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    7. Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Objectives: The purpose of this document is to make the output of the International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available to medical and scientific communities, through a peer-reviewed publication, in the interest of improving the diagnosis and treatment of patients with atherosclerosis, including coronary artery disease.Background: Intravascular optical coherence tomography (IVOCT) is a catheter-based modality that acquires images at a resolution of 10 μm, enabling visualization of blood vessel wall microstructure in vivo at an unprecedented level of detail. IVOCT devices are now commercially available worldwide, there is an active user base, and ...

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    8. The impact of an eccentric intravascular ImageWire during coronary optical coherence tomography imaging

      The impact of an eccentric intravascular ImageWire during coronary optical coherence tomography imaging
      Optical Coherence Tomography (OCT) provides high-resolution imaging which enables characterisation of atherosclerosis and vascular response to injury, but to ensure optimal analysis, one must realise potential sources of image distortion. We designed a series of analysesl, using coronary stents as a model, to investigate the influence of wire position on OCT-derived vascular images.
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    9. Imaging algorithm visualizes early heart abnormalities

      Imaging algorithm visualizes early heart abnormalities
      Combining a post-acquisition rearrangement procedure with optical coherence tomography can provide high temporal resolution for capturing subtle dynamics in the early avian embryonic heart. ying abnormalities that occur during early cardiac development is very important for understanding congenital heart defects. Optical coherence tomography (OCT) is a noninvasive imaging modality based on low-coherence interferometry that is capable of micrometer-scale resolution and 1–2mm of depth penetration in embryonic tissue. OCT can visualize and quantify real-time heart dynamics in 3D, making it a useful tool for assessing cardiac development. Real-time volume imaging performed with current systems, however, does not provide the necessary ...
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    10. Optical coherence tomography captures embryonic heart dynamics

      Optical coherence tomography captures embryonic heart dynamics
      An advanced imaging technique has both the spatial and temporal resolution to investigate the developing heart in important animal models such as chicks and mice. In studying the mechanisms that drive early heart formation, researchers rely primarily on static methods such as histology and immunohistochemistry. During cardiac looping, the minuscule heart transforms from a tubular form to a four-chambered heart, a complex process which relies upon mechanical stresses from the functioning heart for feedback. Optical coherence tomography (OCT) imaging emdash a sophisticated, noninvasive technique that can capture detailed images of biological tissue by measuring optical scattering emdash offers the ability ...
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    11. Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: a prospective, double-blinded study

      Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: a prospective, double-blinded study

      Background Endoscopic optical coherence tomography (EOCT) is a high-resolution, cross-sectional tissue-imaging technique that provides microscopic morphologic information. EOCT should detect dysplasia in Barrett's epithelium, but this has not been established in a prospective blinded study. This study evaluated the accuracy of EOCT for the diagnosis and the exclusion of dysplasia in patients with Barrett's esophagus. Methods A 2.4-mm diameter EOCT probe was modified for use with a cap-fitted, two-channel endoscope. Pairs of EOCT image streams and jumbo biopsy specimens were obtained. Endoscopy/EOCT procedures were performed by 4 endoscopists who separately reviewed the EOCT digital images for ...

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    12. Doppler flow imaging using optical coherence tomography

      Doppler flow imaging using optical coherence tomography
      A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a ...
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    13. Optical imaging device

      An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a ...
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    14. Optical imaging device

      An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a ...
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    15. Doppler flow imaging using optical coherence tomography

      Doppler flow imaging using optical coherence tomography
      A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a ...
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    1-15 of 15
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  2. Topics in the News

    1. (15 articles) Andrew M. Rollins
    2. (14 articles) Case Western Reserve University
    3. (5 articles) Michael W. Jenkins
    4. (4 articles) Joseph A. Izatt
    5. (4 articles) Hiram G. Bezerra
    6. (3 articles) Marco A. Costa
    7. (3 articles) David L. Wilson
    8. (2 articles) Siavash Yazdanfar
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    11. (1 articles) University of Illinois at Urbana-Champaign
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    15. (1 articles) Sina Farsiu
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    Doppler flow imaging using optical coherence tomography Optical coherence tomography captures embryonic heart dynamics Imaging algorithm visualizes early heart abnormalities The impact of an eccentric intravascular ImageWire during coronary optical coherence tomography imaging Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation Gated optical coherence tomography (OCT) environmental chamber OCT News 2013 Student Paper Awarded to Pei Ma from Case Western Reserve University Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION Optical coherence refraction tomography University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity