1. Articles from Chong-Jin Kim

    1-13 of 13

    1. Early versus delayed treatment with ticagrelor on residual thrombus after percutaneous coronary intervention in patients presenting with non-ST-elevation acute coronary syndrome: an optical coherence tomography study

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      Early versus delayed treatment with ticagrelor on residual thrombus after percutaneous coronary intervention in patients presenting with non-ST-elevation acute coronary syndrome: an optical coherence tomography study

      Ticagrelor, a P2Y12 antagonist, is well known for its rapid, high-potent inhibition of platelet aggregation by pharmacokinetic studies [ 1 ]. In the PLATO study, ticagrelor, compared to clopidogrel, reduced the incidence of myocardial infarction, stroke, cardiovascular death and definite stent thrombosis, during 12-month follow-up in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) [ 2 , 3 ]. To date, the effect of early ticagrelor administration versus treatment at the time of PCI has not been well studied. The ATLANTIC study demonstrated that prehospital administration of ticagrelor did not improve pre-PCI coronary reperfusion compared to in-hospital treatment [ 4 ]. We aimed to ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    2. Early versus delayed treatment with ticagrelor on residual thrombus after percutaneous coronary intervention in patients presenting with non-ST-elevation acute coronary syndrome an optical coherence tomography study

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      Early versus delayed treatment with ticagrelor on residual thrombus after percutaneous coronary intervention in patients presenting with non-ST-elevation acute coronary syndrome an optical coherence tomography study

      Objective The level of inhibition of platelet aggregation immediately before percutaneous coronary intervention (PCI) is known to be related to early periprocedural outcomes. Ticagrelor is a reversible P2Y12 inhibitor that provides faster and more effective platelet inhibition compared to clopidogrel. This study sought to compare the antiplatelet effect on residual thrombus between early vs. delayed administration of ticagrelor following PCI in patients presenting with non-ST-elevation acute coronary syndromes (NSTE-ACS). Methods and Results Patients presenting with NSTE-ACS were screened in eight Korean centers, and randomized to receive ticagrelor either on presentation (early treatment) or immediately before PCI (delayed treatment). The primary ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    3. Angiographic features of patients with coronary plaque erosion

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      Angiographic features of patients with coronary plaque erosion

      Background Although an in vivo diagnosis of coronary plaque erosion has become possible by optical coherence tomography (OCT), angiographic characteristics of erosion have not been studied. The aim of this study was to investigate the angiographic features of plaque erosion in patients with non-ST elevation acute coronary syndromes (NSTE-ACS). Methods Patients with NSTE-ACS who underwent OCT of the culprit lesion were collected at 11 institutions from 6 countries. Patients were classified as erosion or non-erosion based on OCT images. Angiographic features of both groups were compared. Results Among 494 cases with NSTE-ACS, 242 had plaque erosion and 252 had non-erosion ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    4. SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris

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      SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris

      SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization (TLR). The aim of this study was to assess the relationship between SS and plaque characteristics and post-stent vascular response using optical coherence tomography (OCT) in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions in LAD, were analyzed. Patients were stratified into tertiles. In pre-PCI analysis of whole coronary tree and LAD, lesions of the 3 rd tertile had the highest prevalence of lipid ...

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      Mentions: University of Queensland Massachusetts General Hospital Ik-Kyung Jang

    5. SYNTAX Score and Pre- and Poststent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients With Stable Angina Pectoris

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      SYNTAX Score and Pre- and Poststent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients With Stable Angina Pectoris

      SYNTAX score (SS) has been reported to be an independent predictor of future cardiac events including target lesion revascularization. The aim of this study was to assess the relation between SS and plaque characteristics and poststent vascular response using optical coherence tomography in coronary artery tree and left anterior descending artery (LAD) in patients with stable angina. A total of 179 lesions among 165 patients, including 100 lesions in LAD, were analyzed. Patients were stratified into tertiles. In pre–percutaneous coronary intervention analysis of whole coronary tree and LAD, lesions of the third tertile had the highest prevalence of lipid-rich ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    6. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

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      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel. Major adverse cardiac events (MACE) were defined as a composite of cardiac death, acute myocardial infarction, and ischemia-driven revascularization. Patients were followed for ...

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      Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

    7. Prevalence and Predictors of Multiple Coronary Plaque Ruptures In Vivo 3-Vessel Optical Coherence Tomography Imaging Study

      Explore atvb.ahajournals.org Cardiology
      Prevalence and Predictors of Multiple Coronary Plaque Ruptures In Vivo 3-Vessel Optical Coherence Tomography Imaging Study

      Objective— Plaque rupture may be the local expression of a widespread coronary instability. This study aimed to investigate: (1) the prevalence and characteristics of nonculprit plaque rupture; (2) the pancoronary atherosclerotic phenotype in patients with and without nonculprit plaque rupture; and (3) the prevalence and predictors of multiple plaque ruptures. Approach and Results— Six hundred and seventy-five nonculprit plaques from 261 patients (34 acute myocardial infarction, 73 unstable angina pectoris, and 154 stable angina pectoris) were analyzed by 3-vessel optical coherence tomography. Nonculprit plaque ruptures were identified in 51 patients (20%). Patients with nonculprit plaque ruptures had higher prevalence of ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    8. Comparison of Neoatherosclerosis and Neovascularization Between Patients With and Without Diabetes : An Optical Coherence Tomography Study

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      Comparison of Neoatherosclerosis and Neovascularization Between Patients With and Without Diabetes : An Optical Coherence Tomography Study

      Objectives This study aimed to investigate the characteristics of neoatherosclerosis (NA) in patients with diabetes mellitus (DM) after drug-eluting stent (DES) implantation using optical coherence tomography. Background NA is an important substrate for stent failure. In vivo NA characteristics in DM patients have not been investigated. Methods A total of 397 patients with 452 DES who underwent follow-up optical coherence tomography examination after DES implantation were enrolled. Characteristics of NA were compared between DM and non-DM patients. Neovascularization was defined as signal-poor holes or tubular structures with a diameter of 50 to 300 μm. Results A total of 123 DES ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    9. Comparison of zotarolimus-eluting stent and everolimus-eluting stent for vascular healing response: serial 3-month and 12-month optical coherence tomography study

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      Comparison of zotarolimus-eluting stent and everolimus-eluting stent for vascular healing response: serial 3-month and 12-month optical coherence tomography study

      Background: Everolimus-eluting stents (EES) have shown favorable clinical outcomes. However, there have been no studies evaluating early vascular response after EES implantation. We designed a prospective study to compare the neointimal response between zotarolimus-eluting stents (ZES) and EES at 3 and 12 months using serial optical coherence tomography examinations. Methods and results: Sixty patients who underwent 3-month and 12-month follow-up optical coherence tomography (36 EES, 24 ZES) were included. Neointimal coverage and malapposition were evaluated using a strut-based analysis at both 3 and 12 months. Neointimal hyperplasia area and thrombus were assessed. ZES showed a higher incidence of covered struts ...

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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    10. Rapid Stent Surface Coverage After Endothelial Progenitor Cell Capture (Genous) Stent Implantation: First Optical Coherence Tomography Report

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      Rapid Stent Surface Coverage After Endothelial Progenitor Cell Capture (Genous) Stent Implantation: First Optical Coherence Tomography Report

      A 78-year-old man was referred for anterior wall motion abnormality on echocardiogram. In anticipation of the urgent surgery for stomach cancer, an endothelial progenitor cell Genous capture stent (Orbus Neich Medical Technology) was implanted. After 2 weeks, optical coherence tomography was done to confirm the coverage of stent struts and all struts were fully covered by reendothelialization. The patient could undergo stomach surgery without antiplatelet therapy successfully.

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      Mentions: Abbot

    12. Vulnerable Plaque Inside Stent

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      Vulnerable Plaque Inside Stent
      IT HAS BEEN PROPOSED THAT NONHEALING ENDOTHELIUM after percutaneous coronary intervention may allow for insudation of lipids superficial to the stent strut level, especially when the underlying plaque carried a large necrotic core. This may result in formation of a lipid-rich neointima, and the lipid core so created is referred to as nouveau atherosclerosis; the neointimal lipid accumulation is physically not connected to the original (pre-interventional) lipid core (1). The likelihood of development of nouveau atherosclerosis is substantially enhanced in the presence of drug-eluting stents, which further delay the endothelial healing. Furthermore, new atherosclerosis occurs much earlier in drug-eluting stent ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University

    13. Spontaneous Recanalization of a Coronary Artery After Thrombotic Occlusion: In Vivo Demonstration With Optical Coherence Tomography

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      Spontaneous Recanalization of a Coronary Artery After Thrombotic Occlusion: In Vivo Demonstration With Optical Coherence Tomography
      A 50-year-old man with a recent embolic stroke was referred by a neurologist for abnormal electrocardiography results consistent with large anterior myocardial infarction. Echocardiogram results showed akinesis of the anteroapical left ventricular wall without obvious mural thrombus and an ejection fraction of 45%. There was no evidence of an intracardiac shunt. Coronary angiography revealed irregular linear filling defects in the mid left anterior descending artery (A) (line 1 and 2 indicate the length of optical coherence tomography pullback). Optical coherence tomography showed multiple channels surrounding a larger central lumen (B, arrowheads). The channels were seen to communicate both with each ...
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      Mentions: Massachusetts General Hospital Ik-Kyung Jang Harvard University
    1-13 of 13
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    Spontaneous Recanalization of a Coronary Artery After Thrombotic Occlusion: In Vivo Demonstration With Optical Coherence Tomography Vulnerable Plaque Inside Stent Coronary perforation during conventional time domain optical coherence tomography Rapid Stent Surface Coverage After Endothelial Progenitor Cell Capture (Genous) Stent Implantation: First Optical Coherence Tomography Report Comparison of zotarolimus-eluting stent and everolimus-eluting stent for vascular healing response: serial 3-month and 12-month optical coherence tomography study Comparison of Neoatherosclerosis and Neovascularization Between Patients With and Without Diabetes : An Optical Coherence Tomography Study Prevalence and Predictors of Multiple Coronary Plaque Ruptures In Vivo 3-Vessel Optical Coherence Tomography Imaging Study Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study SYNTAX Score, and Pre- and Post-Stent Optical Coherence Tomography Findings in the Left Anterior Descending Coronary Artery in Patients with Stable Angina Pectoris Angiographic features of patients with coronary plaque erosion Retinal Vascular Features in Ocular Blunt Trauma by Optical Coherence Tomography Angiography Non-invasive imaging of a choroidal macrovessel