1. Articles from Kazuhiro Sasaki

    1-4 of 4
    1. Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics

      Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics

      Retinal and choroidal vascular imaging is a key to the better understanding and diagnosis of eye diseases. To achieve comprehensive three-dimensional capillary imaging, we used an enhanced vascular imaging technique, so called adaptive optics optical coherence angiography (AO-OCA). AO-OCA enables in vivo high-resolution and high-contrast micro-vascular imaging by detecting Doppler frequency shifts. Using this technique, the retinal and choroidal vasculatures of healthy subjects were imaged. The results show that both intensity and Doppler power images have sufficient contrast to discriminate almost all vasculatures from the static tissue. However, the choriocapillaris, pre-arterioles, and post-venules in the Sattler layer were more contrasted ...

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    2. Extended depth of focus adaptive optics spectral domain optical coherence tomography

      Extended depth of focus adaptive optics spectral domain optical coherence tomography
      We present an adaptive optics spectral domain optical coherence tomography (AO-SDOCT) with a long focal range by active phase modulation of the pupil. A long focal range is achieved by introducing AO-controlled third-order spherical aberration (SA). The property of SA and its effects on focal range are investigated in detail using the Huygens-Fresnel principle, beam profile measurement and OCT imaging of a phantom. The results indicate that the focal range is extended by applying SA, and the direction of extension can be controlled by the sign of applied SA. Finally, we demonstrated in vivo human retinal imaging by altering the ...
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    3. Simultaneous high-resolution retinal imaging and high-penetration choroidal imaging by one-micrometer adaptive optics optical coherence tomography

      Simultaneous high-resolution retinal imaging and high-penetration choroidal imaging by one-micrometer adaptive optics optical coherence tomography
      Adaptive optics optical coherence tomography (AO-OCT) provides three-dimensional high-isotropic-resolution retinal images in vivo. We developed AO-OCT with a 1.03-μm probing beam and demonstrated high-penetration, high-resolution retinal imaging. Axial scans are acquired with a speed of 47,000 lines/s. AO closed loop is configured with a single deformable mirror. Seven eyes of 7 normal subjects were examined. Signal enhancement was found for all subjects. A rippled interface between nerve fiber layer and ganglion cell layer, boundary between ganglion cell layer and inner plexiform layer, and chorioscleral interface were identified. Simultaneous high-resolution and high-penetration choroidal imaging may be useful for ...
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    4. Adaptive optics spectral domain optical coherence tomography with one-micrometer light source

      Adaptive optics spectral domain optical coherence tomography with one-micrometer light source
      Adaptive optics spectral domain optical coherence tomography (AO SD-OCT) has provided three-dimensional high isotropic resolution retinal images in vivo. In order to enhance the image quality of deep region of the eye, the alternative wavelength of 1-µm has been used for ophthalmic OCT. This study aims to develop AO SD-OCT with one-micrometer probe and demonstrated high penetration and high resolution retinal imaging. A broadband 1-µm SLD light source (Suplerlum) have the center wavelength of 1.03 µm and the spectral bandwidth of 106 nm. Axial scans were obtained by an InGaAs line scan camera with the speed of 47,000 ...
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    1-4 of 4
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  2. Topics in the News

    1. (6 articles) National Institutes of Health
    2. (4 articles) University of Tsukuba
    3. (4 articles) Shuichi Makita
    4. (4 articles) Yoshiaki Yasuno
    5. (3 articles) Center for Ophthalmic Optics and Lasers
    6. (3 articles) Oregon Health & Science University
    7. (3 articles) David Huang
    8. (2 articles) Harvard University
    9. (2 articles) Massachusetts General Hospital
    10. (2 articles) University of Southern California
    11. (2 articles) Brett E. Bouma
    12. (2 articles) Johannes F. de Boer
    13. (2 articles) Mohamed Abou Shousha
    14. (1 articles) Oregon Health & Science University
    15. (1 articles) Masahiro Yamanari
    16. (1 articles) Barry Cense
    17. (1 articles) Imagine Eyes
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    Adaptive optics spectral domain optical coherence tomography with one-micrometer light source Simultaneous high-resolution retinal imaging and high-penetration choroidal imaging by one-micrometer adaptive optics optical coherence tomography Extended depth of focus adaptive optics spectral domain optical coherence tomography Three-dimensional retinal and choroidal capillary imaging by power Doppler optical coherence angiography with adaptive optics The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction Clinical diversity in macular corneal dystrophy: an optical coherence tomography study Imaging Amblyopia: Insights from Optical Coherence Tomography (OCT) Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II Velocity range estimation for liquid flow based on optical micro-angiography Spectral optical coherence tomography findings in an adult patient with syphilitic bilateral posterior uveitis and unilateral punctate inner retinitis In-stent restenosis caused by calcified nodule 11 years after paclitaxel eluting stent implantation treated with drug-coated balloon following rotational atherectom Plaque erosion or coronary artery embolism? Findings from clinical presentation, optical coherence tomographic and histopathological analysis in a case with acute coronary syndrome