1. Articles from Ting-Hao Chen

    1-7 of 7
    1. Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths

      Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths

      Currently, the cochlear implantation procedure mainly relies on using a hand lens or surgical microscope, where the success rate and surgery time strongly depend on the surgeon’s experience. Therefore, a real-time image guidance tool may facilitate the implantation procedure. In this study, we performed a systematic and quantitative analysis on the optical characterization of ex vivo mouse cochlear samples using two swept-source optical coherence tomography (OCT) systems operating at the 1.06-µm and 1.3-µm wavelengths. The analysis results demonstrated that the 1.06-µm OCT imaging system performed better than the 1.3-µm OCT imaging ...

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    2. Effect of A-scan rate and interscan interval on optical coherence angiography

      Effect of A-scan rate and interscan interval on optical coherence angiography

      Optical coherence tomography angiography (OCTA) can provide rapid, volumetric, and noninvasive imaging of tissue microvasculature without the requirement of exogenous contrast agents. To investigate how A-scan rate and interscan time affected the contrast and dynamic range of OCTA, we developed a 1.06-µm swept-source OCT system enabling 100-kHz or 200-kHz OCT using two light sources. After system settings were carefully adjusted, almost the same detection sensitivity was achieved between the 100-kHz and 200-kHz modalities. OCTA of ear skin was performed on five mice. We used the variable interscan time analysis algorithm (VISTA) and the designated scanning protocol with OCTA ...

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    3. A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations

      A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations

      Fourier-domain optical coherence tomography (FD-OCT), including spectral-domain OCT (SD-OCT) and swept-source OCT (SS-OCT), allows the volumetric imaging of the tissue architecture with a faster speed and higher detection sensitivity than does time-domain OCT. Although the hardware implementations of SD-OCT and SS-OCT are different, these technologies share very similar signal processing steps for image reconstruction. In this study, we developed hardware implementations and software architectures to design a generic framework for FD-OCT. For SD-OCT systems, an external synchronization approach was used to realize a data acquisition schematic similar to that used in SS-OCT by carefully managing the timing clocks in the ...

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    4. Near-Field Spectroscopy of Broadband Emissions from γ-Al2O3 Nanocrystals in Cr-Doped Double-Clad Fibers

      Near-Field Spectroscopy of Broadband Emissions from γ-Al2O3 Nanocrystals in Cr-Doped Double-Clad Fibers
      Embedded nanocrystals (NCs) of γ-Al2O3 in SiO2 matrixes of Cr-doped double-clad fibers (CDFs) were fabricated by the codrawing laser-heated pedestal growth technique. The spatially resolved broadband emissions of these NCs were examined as a function of NC morphology and distribution by near-field scanning optical microscopy. Comparison of the measured emissions with crystal-field ligands together with careful examination of the NC morphologies by high-resolution transmission electron microscopy confirmed this broadband emission as being an effect of nanotwinning and the Cr3+–Cr6+ redox reaction. The impact of nanotwinning on the relative strength and emission wavelength of Cr3+ and Cr6+ is potentially beneficial ...
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    5. Non-invasive characterization of the domain boundary and structure properties of periodically poled ferroelectrics

      Non-invasive characterization of the domain boundary and structure properties of periodically poled ferroelectrics
      Shaping the ferroelectric domains as waveguide, grating, lens, and prism are key to the successful penetration of periodically-poled ferroelectrics on various wavelength conversion applications. The complicated structures are, however, difficult to be fully characterized, especially the unexpected index contrast at the anti-parallel domain boundaries are typical in the order of 10−4 or less. An ultrahigh resolution optical coherence tomography was employed to fully characterize the domain boundary and structure properties of a periodically-poled lithium niobate (PPLN) waveguide with an axial resolution of 0.68 μm, an transversal resolution of 3.2 μm, and an index contrast sensitivity of 4x10 ...
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    6. Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel

      Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel
      e microstructural and microspectral characteristics of a vertically aligned liquid crystal display (VA-LCD) panel were obtained noninvasively for the first time. With 1 μm axial and 2 μm transversal resolutions, the cell gap profile beneath the patterned thin-film transistor of the VA-LCD panel can clearly be resolved. The thicknesses of the multiple thin-film layers and the embedded defects can also be unveiled. As far as spectral response is concerned, the light transmittance at the layer boundaries can be estimated from the measured reflectance, which is crucial information for the design of a highly transmissive panel. The color shift of the ...
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    7. Ce^3+:YAG double-clad crystal-fiber-based optical coherence tomography on fish cornea

      Ce^3+:YAG double-clad crystal-fiber-based optical coherence tomography on fish cornea
      A Ce3+:YAG double-clad crystal fiber (DCF) visible emission was used as the light source for optical coherence tomography (OCT). The visible emission was produced from a 10 μm core DCF pumped by a diode laser. The broadband emission and short central wavelength of this light source enabled the realization of 1.5 μm axial resolution in air. The relatively clean spectrum reduced the side lobe of its point-spread function, and therefore facilitated the generation of a high-quality image with less crosstalk between adjacent image pixels. As a demonstration, an Aplocheilus lineatus goldfish was experimented on to map out the ...
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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) National Taiwan University
    2. (1 articles) University of Tsukuba
    3. (1 articles) Chang Gung University
    4. (1 articles) Medical University of Vienna
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    Ce^3+:YAG double-clad crystal-fiber-based optical coherence tomography on fish cornea Microstructural and microspectral characterization of a vertically aligned liquid crystal display panel Non-invasive characterization of the domain boundary and structure properties of periodically poled ferroelectrics Near-Field Spectroscopy of Broadband Emissions from γ-Al2O3 Nanocrystals in Cr-Doped Double-Clad Fibers A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations Effect of A-scan rate and interscan interval on optical coherence angiography Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis Clinical presentation does not affect acute mechanical performance of the Novolimus-eluting bioresorbable vascular scaffold as assessed by optical coherence tomography Evaluating optical coherence tomography (OCT) findings as potential biomarkers in central nervous system (CNS) lymphoma with or without ocular involvement Polarization sensitive optical coherence tomography with single input for imaging depth-resolved collagen organizations Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging