1. Articles from Elaine Nguyen

    1-2 of 2
    1. Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model

      Spectral Doppler optical coherence tomography imaging of localized ischemic stroke in a mouse model
      We report the use of spectral Doppler optical coherence tomography imaging (SDOCTI) for quantitative evaluation of dynamic blood circulation before and after a localized ischemic stroke in a mouse model. Rose Bengal photodynamic therapy (PDT) is used as a noninvasive means for inducing localized ischemia in cortical microvasculature of the mouse. Fast, repeated Doppler optical coherence tomography scans across vessels of interest are performed to record flow dynamic information with high temporal resolution. Doppler-angle-independent flow indices are used to quantify vascular conditions before and after the induced ischemia by the photocoagulation of PDT. The higher (or lower) flow resistive indices ...
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      Mentions: UC Irvine
    2. Functional Doppler optical coherence tomography for cortical blood flow imaging

      Functional Doppler optical coherence tomography for cortical blood flow imaging
      Optical methods have been widely used in basic neuroscience research to study the cerebral blood flow dynamics in order to overcome the low spatial resolution associated with magnetic resonance imaging and positron emission tomography. Although laser Doppler imaging and laser speckle imaging can map out en face cortical hemodynamics and columns, depth resolution is not available. Two-photon microscopy has been used for mapping cortical activity. However, flow measurement requires fluorescent dye injection, which can be problematic. The noninvasive and high resolution tomographic capabilities of optical coherence tomography make it a promising technique for mapping depth resolved cortical blood flow. Here ...
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      Mentions: UC Irvine
    1-2 of 2
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    1. (2 articles) UC Irvine
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