1. Articles from daizo kawasaki

    1-6 of 6
    1. Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Aims: The main cause of acute myocardial infarction (AMI) is the disruption of a thin-cap fibroatheroma (TCFA) and subsequent thrombosis. Mortality increases in diabetic patients due to cardiovascular events; there may be differences in the vulnerable plaques between diabetic and non-diabetic patients. We used optical coherence tomography (OCT) to assess the incidence of vulnerable plaques in diabetic patients with AMI. Methods and results: OCT was performed in all three major coronary arteries of 70 AMI patients: 48 non-diabetic and 22 diabetic patients. The OCT criterion for TCFA was the presence of both a lipid-rich plaque composition and a fibrotic cap ...

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    2. Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation

      Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation

      Background Zotarolimus-eluting stents (ZES) have a higher rate of neointimal coverage than the first-generation drug-eluting stents on optical coherence tomography (OCT). Objective To determine whether neointimal coverage of stent struts detected by OCT can be used as a surrogate for endothelial function after ZES implantation. Design Cross-sectional observational study. Setting Three months after ZES implantation. Patients and methods OCT was performed in 20 patients with a ZES at 3 months after stent implantation to evaluate strut coverage. Endothelium-dependent coronary vasomotion was estimated by infusing incremental doses of acetylcholine into the coronary ostium. The vascular response was measured in the 10 ...

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    3. OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

      OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

      Objectives We evaluated the geographic distribution of thin-cap fibroatheromas (TCFAs) in the coronary arteries using optical coherence tomography (OCT), a high-resolution imaging modality. Background Plaque rupture is the most frequent cause of acute myocardial infarction (AMI). It has been recognized that TCFA is the primary plaque type at the site of plaque rupture. Methods We performed 3-vessel OCT examinations in 55 patients: 35 AMI and 20 stable angina pectoris patients. The criteria for TCFA in an OCT image was a lipid-rich plaque with fibrotic cap thickness <65 µm. The distance between each TCFA location and the respective coronary artery ostium ...

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    4. Effect of Atorvastatin on the Stability of Thin-cap Fibroatheroma: A Three-Vessel Optical Coherence Tomography and Intravascular Ultrasound Study

      Background: It is well known that administration of statins for patients with acute myocardial infarction is effective for secondary prevention of cardiovascular events. It is generally assumed that effects of statins would result from their effects on atherosclerotic lesions including stabilization of plaques, but effects of statins on plaque vulnerability have not been fully elucidated. Therefore, we evaluated the impact of atorvastatin on the fibrous cap thickness of thin-cap fibroatheroma (TCFA), which is recognized as precursor lesion of plaque rupture, using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in vivo. Methods: OCT and IVUS examinations were performed in all ...

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    5. Coronary Plaque Characteristics of Thin-cap Fibroatheroma: An Intravascular Ultrasound and Optical Coherence Tomography Study

      Background: Previous pathologic studies reported that the main mechanisms of acute coronary syndrome (ACS) are atherosclerotic plaque ruptures followed by thrombus formation. Therefore it is clinically important to identify plaques that are prone to rupture, known as thin-cap fibroatheroma (TCFA). The aim of this study is to evaluate plaque characteristics of TCFA using optical coherence tomography (OCT) in vivo. Methods: After the successful treatment of culprit lesions, OCT and intravascular ultrasound (IVUS) examinations were attempted prospectively using motorized pullback in all 3 major coronary arteries for 41 ACS and 42 stable angina pectoris (SAP) patients. In 78 patients, 303 moderate ...
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    6. Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study

      Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study

      (A) A 90% stenosis observed in the middle left anterior descending artery in patients with stable angina pectoris (arrow). (B) Lipid-rich plaque (L) covered by thin fibrous cap (63.3 µm) (arrowheads) observed in the target lesion of a patient with stable angina pectoris. (C) Lipid-rich plaque (L) covered by thin fibrous cap (arrowheads) detected in the noninfarct-related lesion of an acute myocardial infarction patient. (D) Magnification of (C). The thickness of the fibrous cap that existed betw

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    1-6 of 6
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