1. Articles from tohru masuyama

    1-17 of 17
    1. Impact of low tissue backscattering by optical coherence tomography on endothelial function after drug-eluting stent implantation

      Impact of low tissue backscattering by optical coherence tomography on endothelial function after drug-eluting stent implantation

      This study evaluated the impact of optical coherence tomography (OCT)-derived low-backscattered tissue on mid-term coronary endothelial function after drug-eluting stent (DES) implantation. Although OCT enables detailed in vivo evaluation of neointimal tissue characterization after DES implantation, its association with physiological vascular healing response is unclear. Thirty-three stable angina pectoris patients underwent OCT examination and endothelial function testing with intracoronary infusion of incremental doses of acetylcholine 8-month after DES implantation in a single lesion of the left anterior descending artery. Neointimal tissue was classified into two patterns based on the predominant OCT light backscatter: high backscatter and low backscatter. Although ...

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      Mentions: Kenichi Fujii
    2. Potential of new generation double-layer micromesh stent for carotid artery stenting in patients with unstable plaque ∼ A preliminary result using OFDI analysis ∼

      Potential of new generation double-layer micromesh stent for carotid artery stenting in patients with unstable plaque ∼ A preliminary result using OFDI analysis ∼

      Background One of the disadvantages of carotid artery stenting (CAS) is high incidence of distal embolism (DE) during or after the procedure. It has been reported that unstable plaque cases are at high risk of DE and plaque protrusion (PP) after stent placement which will become a cause of post procedural ischemic complications. Objective The purpose of this study was to compare the rate and size of PP between CASPER stent which is a new generation double-layer micromesh stent and conventional stents detected by optical frequency domain imaging (OFDI) and to evaluate the efficacy of CAS with CASPER stent for ...

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    3. Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study

      Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study

      Aims: This study sought to investigate differences in vascular response between self-expanding bare metal nitinol stents (BMS) and paclitaxel-eluting nitinol stents (PES), in superficial femoral artery (SFA) disease, using optical frequency domain imaging (OFDI). Methods and results: Six months after stent implantation, follow-up quantitative vascular angiography (QVA) and OFDI assessment were scheduled to evaluate vascular response. Volume index (VI) was defined as volume divided by stent length. The primary endpoint was OFDI-derived late lumen area loss, defined as lumen VI post stent implantation minus lumen VI at follow-up. A total of 28 SFA lesions were analysed, with cases randomised to ...

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    4. Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Background Optical coherence tomography (OCT) is one of the tools trying to distinguish neoatherosclerosis from other neointimal tissue but its role has to be still validated. This study evaluated the diagnostic accuracy of OCT for characterization of lipid-atherosclerotic neointima following drug-eluting stent (DES) implantation. Methods Twelve stented coronary arteries from the 7 autopsy hearts were imaged by OCT. These OCT images were compared with histology. By OCT, the morphological appearances of neointima were classified into three patterns: homogeneous pattern, heterogeneous pattern with visible strut, or heterogeneous pattern with invisible strut. Results Of 21 histological cross-sections, 6 were categorized as homogeneous ...

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    5. Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study –

      Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study –

      Background: We performed an ex vivo study to investigate optical coherence tomography (OCT) imaging for differentiating several types of neointimal tissue during the later phases after bare-metal stent (BMS) implantation as compared with histologic results. Methods and Results: OCT imaging was performed in 6 autopsy hearts for 10 BMS with implant duration >4 years. OCT qualitative neointimal tissue characterization was based on tissue structure and classified as homogeneous pattern, heterogeneous pattern with visible struts, or heterogeneous pattern with invisible struts. Corresponding histological analyses of each 2-mm cross-section of the entire BMS were performed. Of 81 cross-sections, histological analysis revealed that ...

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      Mentions: Abbot Kenichi Fujii
    6. Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Objectives This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA). Background The extent to which the imaging characteristics of OCT and IVUS correlate with histologically defined TCFA is unknown. Methods IVUS and OCT examinations identified focal plaques in 165 coronary arteries from 60 autopsy hearts. A total of 685 pairs of images of OCT and IVUS were compared with histology. By OCT, a TCFA was defined as a signal-poor region with diffuse borders and cap thickness <65 μm. By IVUS, a TCFA was defined by ...

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    7. Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy

      Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy

      An 89-year-old woman who suffered a stroke and congestive heart failure was admitted to our hospital. She died of heart failure and autopsy was performed. Coronary arteries were removed from the heart and used for ex vivo imaging of intravascular ultrasound ([IVUS]; Atlantis, Boston Scientific Corporation, Natick, Massachusetts), optical coherence tomography (LightLab imaging Inc., Westford, Massachusetts), and coronary angioscopy (FiberTech, Tokyo, Japan) within 6 h after death before fixation with 10% buffered formalin. IVUS illustrated a convex lesion with superficial hyperechoic signal accompanied by acoustic shadowing at the left anterior descending artery (Figure 1 , arrows). Optical coherence tomography demonstrated an ...

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    8. Can Optical Coherence Tomography Findings Be Used as Surrogates for Vessel Healing After Drug-Eluting Stent Implantation?

      Can Optical Coherence Tomography Findings Be Used as Surrogates for Vessel Healing After Drug-Eluting Stent Implantation?

      Drug-eluting stents (DES) inhibit neointimal proliferation and reduce the rates of subsequent target lesion revascularization as compared with bare-metal stents in randomized clinical trials.1,2 However, too much inhibition of neointimal hyperplasia might cause delayed vascular healing with incomplete endothelialization, which has been associated with an increase risk of stent thrombosis.3,4 Therefore, accurate assessment of the neointimal coverage in DES may be critical in prognosticating their safety. Optical coherence tomography (OCT) uses near-infrared light and generate crosssectional images by measuring the echo time delay and intensity of light that is reflected or back-scattered from the tissue. The ...

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      Mentions: Kenichi Fujii
    9. Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography

      Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography

      Although previous optical coherence tomography (OCT) studies reported that restenosis tissue after implantation of a drug-eluting stent (DES) was composed of a variety of cells, the clinical significance of morphologic characteristics for in-stent neointimal tissue as assessed by OCT has not been clarified. We experienced a patient with stable angina who underwent percutaneous coronary intervention with a 2.5 × 18-mm DES implantation 6 months before the OCT examination. OCT imaging showed a mild intimal hyperplasia (39 % neointimal hyperplasia) with eccentric, heterogeneous tissue, predominantly of low signal intensity. Seventeen months after the initial procedure, OCT revealed a significant increase in percent ...

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    10. Intracoronary Imaging for Detecting Vulnerable Plaque

      Intracoronary Imaging for Detecting Vulnerable Plaque

      It is now generally recognized that acute coronary syndromes most commonly result from disruption of thin-cap fibroatheroma (TCFA), which is characterized by a large necrotic core with an overlying thin-fibrous cap measuring <65μm. Recent advances in intracoronary imaging modalities have significantly improved the ability to detect TCFA in vivo. Intravascular ultrasound (IVUS) is perhaps the most promising modality that has been used more than 15 years to evaluate atherosclerotic plaque. IVUS has revealed a lot of the clinical evidence regarding vulnerable plaque detection in live humans. Recently, by analyzing the IVUS acoustic signal before demodulation and scan conversion, IVUS ...

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    11. Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study

      Aims: The main cause of acute myocardial infarction (AMI) is the disruption of a thin-cap fibroatheroma (TCFA) and subsequent thrombosis. Mortality increases in diabetic patients due to cardiovascular events; there may be differences in the vulnerable plaques between diabetic and non-diabetic patients. We used optical coherence tomography (OCT) to assess the incidence of vulnerable plaques in diabetic patients with AMI. Methods and results: OCT was performed in all three major coronary arteries of 70 AMI patients: 48 non-diabetic and 22 diabetic patients. The OCT criterion for TCFA was the presence of both a lipid-rich plaque composition and a fibrotic cap ...

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    12. Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation

      Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation

      Background Zotarolimus-eluting stents (ZES) have a higher rate of neointimal coverage than the first-generation drug-eluting stents on optical coherence tomography (OCT). Objective To determine whether neointimal coverage of stent struts detected by OCT can be used as a surrogate for endothelial function after ZES implantation. Design Cross-sectional observational study. Setting Three months after ZES implantation. Patients and methods OCT was performed in 20 patients with a ZES at 3 months after stent implantation to evaluate strut coverage. Endothelium-dependent coronary vasomotion was estimated by infusing incremental doses of acetylcholine into the coronary ostium. The vascular response was measured in the 10 ...

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    13. OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

      OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

      Objectives We evaluated the geographic distribution of thin-cap fibroatheromas (TCFAs) in the coronary arteries using optical coherence tomography (OCT), a high-resolution imaging modality. Background Plaque rupture is the most frequent cause of acute myocardial infarction (AMI). It has been recognized that TCFA is the primary plaque type at the site of plaque rupture. Methods We performed 3-vessel OCT examinations in 55 patients: 35 AMI and 20 stable angina pectoris patients. The criteria for TCFA in an OCT image was a lipid-rich plaque with fibrotic cap thickness <65 µm. The distance between each TCFA location and the respective coronary artery ostium ...

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    14. Effect of Atorvastatin on the Stability of Thin-cap Fibroatheroma: A Three-Vessel Optical Coherence Tomography and Intravascular Ultrasound Study

      Background: It is well known that administration of statins for patients with acute myocardial infarction is effective for secondary prevention of cardiovascular events. It is generally assumed that effects of statins would result from their effects on atherosclerotic lesions including stabilization of plaques, but effects of statins on plaque vulnerability have not been fully elucidated. Therefore, we evaluated the impact of atorvastatin on the fibrous cap thickness of thin-cap fibroatheroma (TCFA), which is recognized as precursor lesion of plaque rupture, using optical coherence tomography (OCT) and intravascular ultrasound (IVUS) in vivo. Methods: OCT and IVUS examinations were performed in all ...

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    15. Coronary Plaque Characteristics of Thin-cap Fibroatheroma: An Intravascular Ultrasound and Optical Coherence Tomography Study

      Background: Previous pathologic studies reported that the main mechanisms of acute coronary syndrome (ACS) are atherosclerotic plaque ruptures followed by thrombus formation. Therefore it is clinically important to identify plaques that are prone to rupture, known as thin-cap fibroatheroma (TCFA). The aim of this study is to evaluate plaque characteristics of TCFA using optical coherence tomography (OCT) in vivo. Methods: After the successful treatment of culprit lesions, OCT and intravascular ultrasound (IVUS) examinations were attempted prospectively using motorized pullback in all 3 major coronary arteries for 41 ACS and 42 stable angina pectoris (SAP) patients. In 78 patients, 303 moderate ...
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    16. Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study

      Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study

      (A) A 90% stenosis observed in the middle left anterior descending artery in patients with stable angina pectoris (arrow). (B) Lipid-rich plaque (L) covered by thin fibrous cap (63.3 µm) (arrowheads) observed in the target lesion of a patient with stable angina pectoris. (C) Lipid-rich plaque (L) covered by thin fibrous cap (arrowheads) detected in the noninfarct-related lesion of an acute myocardial infarction patient. (D) Magnification of (C). The thickness of the fibrous cap that existed betw

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    1-17 of 17
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    1. (14 articles) Kenichi Fujii
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    Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries Endothelium-dependent coronary vasomotor response and neointimal coverage of zotarolimus-eluting stents 3 months after implantation Multiple complex coronary atherosclerosis in diabetic patients with acute myocardial infarction: a three-vessel optical coherence tomography study Intracoronary Imaging for Detecting Vulnerable Plaque Natural history of low-intensity neointimal tissue after an everolimus-eluting stent implantation: a serial observation with optical coherence tomography In-Stent Thin-Cap Fibroatheroma After Drug-Eluting Stent Implantation: Ex-Vivo Evaluation of Optical Coherence Tomography and Intracoronary Angioscopy Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy Clinical Usefulness of a Novel Optical Coherence Tomography Procedure, “Low Molecular Weight Dextran Infusion Followed by Catheter PUSH (D-PUSH)” Optical Coherence Tomography to Guide Percutaneous Coronary Intervention of the Left Main Coronary Artery: the LEMON study Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study OCTA Multilayer and Multisector Peripapillary Microvascular Modeling for Diagnosing and Staging of Glaucoma