1. Articles from James Fujimoto

    1-21 of 21
    1. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in the management of patients with acute coronary syndromes. Detection by OCT of healed coronary plaque has been important in our understanding of the mechanisms involved in plaque destabilization and healing ...

      Read Full Article
    2. Deliberations of an International Panel of Experts on OCTA Nomenclature of nAMD

      Deliberations of an International Panel of Experts on OCTA Nomenclature of nAMD

      A panel of imaging experts was assembled to review neovascular age-related macular degeneration optical coherence tomography angiography descriptors published to date, and test agreement on use of these terms, which was found to be low. Optical coherence tomography angiography (OCTA) has been used to identify and characterize macular neovascularization (MNV) secondary to age-related macular degeneration (AMD). 1-4 Many studies have explored OCTA morphological features of MNV that might serve as biomarkers to assess disease activity and response to treatment. 1-6 The proliferation of studies however has resulted in an OCTA terminology that has been variable and inconsistent. To address inconsistency ...

      Read Full Article
    3. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.

      Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition. Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an UHR SD-OCT prototype, with an 850 nm center wavelength and an axial resolution of ~2.7 µm in tissue at a 128kHz A-scan rate. Volumetric cube scans and high-density (HD ...

      Read Full Article
    4. Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Evaluating the long-term effects of anti-vascular endothelial growth factor therapy on choroidal neovascularization in age-related macular degeneration using optical coherence tomography angiography

      Purpose : Optical coherence tomography angiography (OCTA) allows for precise, non-invasive monitoring of changes to choroidal neovascularization (CNV) structure over time. The short-term effects of anti-vascular endothelial growth factor (anti-VEGF) treatment on CNV morphology is well described, but long-term studies on morphologic changes and correlation of such to the type of CNV have not been conducted. This study aims to determine if different types of CNVs in neovascular AMD (nAMD) behave differently with anti-VEGF treatment as visualized on OCTA. Methods : AMD Patients with treatment naive type 1, type 2, and type 3 CNVs were retrospectively screened for baseline and follow-up OCTA ...

      Read Full Article
    5. Ultrahigh-Resolution Optical Coherence Tomography Investigation of Age-Related Changes in the Photoreceptors, Retinal Pigment Epithelium and Bruch’s Membrane

      Ultrahigh-Resolution Optical Coherence Tomography Investigation of Age-Related Changes in the Photoreceptors, Retinal Pigment Epithelium and Bruch’s Membrane

      Purpose : Aging is the biggest risk factor for age-related macular degeneration (AMD). Previous histological and ultrastructural studies have suggested that photoreceptors (PR), retinal pigment epithelium (RPE), and Bruch’s membrane (BM) undergo changes with aging and in AMD. A new high-speed, ultrahigh-resolution optical coherence tomography (UHR OCT) prototype instrument with depth tracking and software motion correction was used to investigate PR/RPE/BM alterations in normal aging and early AMD. Methods : We developed a high-speed UHR OCT instrument with 2.7 µm axial resolution and 128 kHz A-scan rate. A galvanometer scanner actuates the OCT reference arm to match the ...

      Read Full Article
    6. Healed Culprit Plaques in Patients With Acute Coronary Syndrome

      Healed Culprit Plaques in Patients With Acute Coronary Syndrome

      ackground Healed plaques, morphologically characterized by a layered phenotype, are frequently found in subjects with sudden cardiac death. However, in vivo data are lacking. Objectives The purpose of this study was to determine the prevalence, morphological characteristics, and clinical significance of healed culprit plaques in patients with acute coronary syndromes (ACS) using optical coherence tomography (OCT). Methods A total of 376 ACS patients (252 ST-segment elevation myocardial infarction [MI] and 124 non–ST-segment elevation acute coronary syndrome) who had undergone pre-intervention OCT imaging of the culprit lesion were enrolled. Patients were stratified according to the presence of layered phenotype, defined ...

      Read Full Article
    7. Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography

      Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography

      (1) Background: Barrett’s esophagus (BE) is a complication of chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The clinical implication of subsurface glandular structures of Barrett’s esophagus is not well understood. Optical coherence tomography (OCT), also known as volumetric laser endomicroscopy (VLE), can assess subsurface glandular structures, which appear as subsurface hyposcattering structures (SHSs). The aim of this study is to develop a computer-aided algorithm and apply it to investigate the characteristics of SHSs in BE using clinical VLE data; (2) Methods: SHSs were identified with an initial detection followed by machine learning. Comprehensive SHS ...

      Read Full Article
    8. Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study

      Clinical Predictors for Lack of Favorable Vascular Response to Statin Therapy in Patients With Coronary Artery Disease: A Serial Optical Coherence Tomography Study

      Background Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin‐cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. Methods and Results A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6.3 months) were included. Thin ...

      Read Full Article
    9. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel. Major adverse cardiac events (MACE) were defined as a composite of cardiac death, acute myocardial infarction, and ischemia-driven revascularization. Patients were followed for ...

      Read Full Article
    10. The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited]

      The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited]

      25 years is a relatively short period of time for a medical technology to become a standard of care impacting the treatment of millions of people every year. Yet 25 years ago there were no OCT companies, no OCT products, no OCT markets, and only one journal article published using the term OCT (optical coherence tomography). OCT has had a tremendous scientific, clinical, and economic impact on society. Today, it is estimated that there are ~30 Million OCT imaging procedures performed worldwide every year and the OCT system market is approaching $1B per year. OCT has helped diagnose patients with ...

      Read Full Article
    11. Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      Analysis of Scleral Feeder Vessel in Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      To describe the appearance of a scleral-derived feeder vessel in a highly myopic eye with secondary choroidal neovascularization (CNV) as visualized on both en face high-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype, and a commercially available spectral-domain (SD) OCTA, with the corresponding en face and cross-sectional structural OCT images. In this case report, a 60-year-old white male presented with high myopia and secondary CNV in the right eye, previously treated with anti-vascular endothelial growth factor, and was imaged on both SD-OCT and SS-OCT. The neovascular complex could be visualized on both devices. Structural en face SS-OCT images demonstrated ...

      Read Full Article
    12. Foreword: 25 Years of Optical Coherence Tomography

      Foreword: 25 Years of Optical Coherence Tomography

      This special issue commemorates the 25th anniversary of the development of optical coherence tomography (OCT). OCT has had a transformative impact in the field of ophthalmology and vision research, contributing to fundamental understanding of disease pathogenesis, drug discovery and development, and everyday clinical decision making in all ophthalmic subspecialties. The role of OCT in research and clinical care continues to accelerate, as judged by the cumulative number of publications in scientific journals ( Fig. 1 ). Ophthalmic applications have developed the earliest, and continue to be the primary area of research and clinical application for OCT. In the past decade, OCT has ...

      Read Full Article
    13. Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents

      Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents

      Objective: Methods for intravascular assessment of the side-branch (SB) orifice after stenting are not readily available. The aim of this study was to assess the utility of an en-face projection processing for optical coherence tomography (OCT) images for SB evaluation. Methods: Measurements of the SB orifice obtained using en-face OCT images were validated using a phantom model. Linear regression modeling was applied to estimated area measurements made on the en-face images. The SB orifice was then analyzed in 88 patients with bifurcation lesions treated with either Xience V (everolimus-eluting stent) or Resolute Integrity [zotarolimus-eluting stent (ZES)]. The SB orifice area ...

      Read Full Article
    14. Optical Coherence Tomography: Technology and Applications Second Edition (Textbook)

      Optical Coherence Tomography: Technology and Applications Second Edition (Textbook)

      New medical imaging technologies can improve the diagnosis and clinical management of many diseases. Furthermore, advanced imaging also contributes to a better understanding of pathogenesis and therefore to the development of new pharmaceuticals and novel therapies. Thus, imaging plays a critical role in modern medical research and clinical practice. Noninvasive or minimally invasive imaging techniques have revolutionized diagnostic medicine during the last decades, e.g., X-ray computed tomography (CT), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), radioisotope imaging (position emission tomography (PET)), single-photon emission computed tomography (SPECT), and diffuse optical tomography (DOT). These techniques permit three-dimensional visualization; however ...

      Read Full Article
    15. Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection

      Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection

      Optical coherence tomography (OCT) is a widely used three-dimensional (3D) optical imaging method with many biomedical and non-medical applications. Miniaturization, cost reduction, and increased functionality of OCT systems will be critical for future emerging clinical applications. We present a silicon photonic integrated circuit swept-source OCT (SS-OCT) coherent receiver with dual polarization, dual balanced, in-phase and quadrature (IQ) detection. We demonstrate multiple functional capabilities of IQ polarization resolved detection including: complex-conjugate suppressed full-range OCT, polarization diversity detection, and polarization-sensitive OCT. To our knowledge, this is the first demonstration of a silicon photonic integrated receiver for OCT. The integrated coherent receiver provides ...

      Read Full Article
    16. Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging ...

      Read Full Article
    17. Methods and apparatus for optical coherence tomography scanning

      Methods and apparatus for optical coherence tomography scanning

      Optical coherence tomography performs cross-sectional imaging, three-dimensional imaging, or data acquisition in materials or biological tissue by measuring the magnitude and time delay of backscattered or backreflected light from inside the sample. OCT performs imaging or measurement by directing a light beam at the sample, measuring the backscattering or backreflected signal from the sample as a function of the optical delay (known as an axial scan or A-scan), and scanning the OCT beam incident on the tissue or material to generate a two or three dimensional dataset which represents cross-sectional or volumetric information about the internal structure of the sample ...

      Read Full Article
    18. Methods and apparatus for optical coherence tomography scanning

      Methods and apparatus for optical coherence tomography scanning
      In one aspect, the invention relates to a method of acquiring optical coherence tomographic data from a sample. The method includes the steps of scanning a first location on the sample to obtain a first set of optical coherence tomographic data, scanning a second location on the sample to obtain a second set of optical coherence tomographic data, and defining a fiducial position relative to a location on the sample using one of the two sets of optical coherence tomographic data. In one embodiment, the first set of optical coherence tomographic data is survey data. However, in another embodiment the ...
      Read Full Article
    19. Doppler optical coherence tomography for imaging of brain hemodynamics

      Doppler optical coherence tomography for imaging of brain hemodynamics

      Advanced microscopic techniques enable depth-resolved imaging of changes in blood flow during brain activation. ptical imaging has become an important tool in neuroscience research.1 Using methods such as optical intrinsic signal imaging (OISI), laser-Doppler imaging, and laser-speckle imaging, investigators can record changes in blood flow and blood volume in the brain, as well as alterations in blood oxygen concentration, in response to different types of stimulation. By measuring these changes, they can gain deeper insight into the functioning of the brain, which in turn can contribute to better understanding of a range of behaviors and conditions. However, these techniques ...

      Read Full Article
    20. Mode locking methods and apparatus

      FIELD OF THE INVENTIONT he invention relates generally to the field of wave generation. In particular, the invention relates to Fourier Domain Mode Locking (FDML) and applications thereof. BACKGROUND OF THE INVENTIONIn many industries and technical areas of research, various systems and devices are used to obtain precise measurements or imaging. In conjunction with the need for precision, there is also a demand for high speed data collection. To satisfythese two criteria, many wave-based technolog
      Read Full Article
    1-21 of 21
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (20 articles) Massachusetts Institute of Technology
    2. (8 articles) Harvard University
    3. (7 articles) Massachusetts General Hospital
    4. (5 articles) Tufts University
    5. (4 articles) Kawasaki Medical School
    6. (3 articles) University of Melbourne
    7. (3 articles) Kyung Hee University
    8. (2 articles) Nippon Medical School
    9. (2 articles) University of Ulsan
    10. (2 articles) Thorlabs
    11. (1 articles) Sun Yat-Sen University
    12. (1 articles) Chinese Academy of Sciences
  3. Popular Articles

  4. Picture Gallery

    Doppler optical coherence tomography for imaging of brain hemodynamics Methods and apparatus for optical coherence tomography scanning Methods and apparatus for optical coherence tomography scanning Ultrahigh speed endoscopic optical coherence tomography for gastroenterology Silicon photonic integrated circuit swept-source optical coherence tomography receiver with dual polarization, dual balanced, in-phase and quadrature detection Optical Coherence Tomography: Technology and Applications Second Edition (Textbook) Quantitative analysis of the side-branch orifice after bifurcation stenting using en-face processing of OCT images: a comparison between Xience V and Resolute Integrity stents The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited] Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study Asynchronous feature regularization and cross-modal distillation for OCT based glaucoma diagnosis Developments and Clinical Applications of Noninvasive Optical Technologies for Skin Cancer Diagnosis Retinal Pigment Epithelial Changes in Parkinson's Disease: A Spectral Domain Optical Coherence Tomography Study