1. Articles from Kate Lawlor

    1-2 of 2
    1. In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography

      In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography
      The use of microneedles as a method of circumventing the barrier properties of the stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth and closure kinetics of microneedle-induced skin pores are available, primarily due to the cumbersome techniques currently required for skin analysis. We report on the first use of optical coherence tomography technology to image microneedle penetration in real time and in vivo. We show that optical coherence tomography (OCT) can be used to painlessly measure stratum corneum and epidermis thickness, as well as ...
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    2. A gel-based skin and blood flow model for a Doppler optical coherence tomography (DOCT) imaging system

      A gel-based skin and blood flow model for a Doppler optical coherence tomography (DOCT) imaging system
      Since its discovery in 1842 by Christian Johann Doppler, the Doppler Effect has had many applications in the scientific world. In recent years, the phenomenon has been integrated with Optical Coherence Tomography (OCT) yielding Doppler Optical Coherence Tomography (DOCT), a technique that is useful for high-resolution imaging of the skin microcirculation. However, interpretation of DOCT images is rather challenging. Thus, our study aims to aid understanding of DOCT images with respect to parameters of microcirculation components such as blood vessel size, depth and angular position. To this end, we have constructed a gel-based tissue and blood-flow model for performing DOCT ...
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    1-2 of 2
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  2. Topics in the News

    1. (2 articles) University of Limerick
    2. (2 articles) Martin J. Leahy
    3. (1 articles) University College Cork
    4. (1 articles) National University of Ireland, Galway
    5. (1 articles) Enock Jonathan
    6. (1 articles) University of Melbourne
    7. (1 articles) Dresden University of Technology
    8. (1 articles) University of Washington
    9. (1 articles) University of Bonn
    10. (1 articles) Ruikang K. Wang
    11. (1 articles) Julia Walther
    12. (1 articles) Frank G. Holz
    13. (1 articles) Edmund Koch
    14. (1 articles) Steffen Schmitz-Valckenberg
    15. (1 articles) Heidelberg Engineering
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