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  1. Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation

    Explore Article Institute of Physics (Aug 17 2008)

    Abstract. The possibility of using silica–gold nanoshells with 150 nm silica core size and 25 nm thick gold shell as contrasting agents for optical coherence tomography (OCT) is analyzed. Experiments on agar biotissue phantoms showed that the penetration of nanoshells into the phantoms increases the intensity of the optical coherence tomography (OCT) signal and the brightness of the corresponding areas of the OCT image. In vivo experiments on rabbit skin demonstrated that the application of nanoshells onto the skin provides significant contrasting of the borders between the areas containing nanoshells and those without. This effect of nanoshells on skin in ... (Read Full Article)

    Comment on Article Mentions:   University of Oulu   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova

  2. Monte Carlo modeling of corneal and retinal Optical Coherence Tomography imaging

    Explore Article IEEE Xplore (Aug 12 2008) Ophthalmology

    Monte Carlo simulations of OCT images of cornea and retina was performed for various setup parameters. Several models of cornea and retina were implemented; the optical parameters or the model were chosen basing on the experimental results. Obtained simulated image exhibits qualitative agreement with the experimental ones allowing for preliminary numerical study of OCT technique for ocular structure and ophthalmologic diseases diagnostics. (Read Full Article)

    Comment on Article Mentions:   University of Athens   Mikhail Y. Kirillin   Moscow State University

  3. Role of multiple scattering in formation of OCT skin images

    Explore Article Institute of Physics (Jun 1 2008) Dermatology

    Optical coherence tomography (OCT) images of model human skin samples are obtained by using Monte Carlo simulations. The contributions of least and multiple scattering, diffusion and nondiffusion components and of separate scattering orders are studied by using a multilayer skin model based on experimental images. The model images are obtained by neglecting speckles or taking them into account. It is shown that least scattering forms the image of the upper skin layers, while the contribution of multiple scattering can be characterised as a blurred full image with a lower contrast. Repeated scattering mainly contributes to the OCT image at depths ... (Read Full Article)

    Comment on Article Mentions:   Risto A. Myllylä   University of Oulu   Moscow State University

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