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Articles from e. v. zagaynova

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  1. Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia

    Explore Article SPIE Digital Library (Mar 2 2010) Oncology , Urology

    Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia We consider the cross-polarization OCT (CP OCT) that is focused on comparison of images resulting from cross-polarization and co-polarization scattering simultaneously. This technique provides information about microstructural and biochemical alterations in depolarizing tissue components (collagen). We found that mature type I collagen gives a strong signal in orthogonal polarization. CP OCT images of benign inflammatory processes always feature signal in orthogonal polarization, with layers and borders persisting to be well defined. In the presence of precancerous alterations, signal in orthogonal polarization is available in the image but it is irregular, disappearing in some areas. A CP OCT image of bladder ... (Read Full Article)

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Valentin M. Gelikonov   Elena V. Zagaynova

  2. Compression as a method for increasing the informativity of optical coherence tomography of biotissues

    Explore Article SpringerLink Home (Dec 24 2009)

    The efficiency of the mechanical compression of biotissues for improving the differentiation between pathological changes in the structure of a biotissue observed by the method of optical coherence tomography (OCT) is investigated. The effect of the compression in the OCT-images of samples of the human rectum affected by inflammation and carcinoma is studied ex vivo. It is shown that the use of compression makes it possible to differentiate between these pathological changes. To interpret experimental data, images of an inflamed part of rectum are modeled by the Monte Carlo method for different degrees of compression. The results of modeling agree ... (Read Full Article)

    Comment on Article Mentions:   Russian Academy of Sciences   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova

  3. Cross-polarization endoscopic optical coherence tomography in urology

    Explore Article SPIE Digital Library (Feb 19 2009) Endoscopy

    We present results obtained using a two-channel portable device for CP OCT based on the polarization-maintaining fiber. The device is capable of acquiring OCT images of the object in direct and orthogonal polarizations simultaneously. The OCT system has an endoscopic forward-looking probe (2.7 mm in diameter). The CP OCT imaging was done in 64 postoperative specimens, for 30 patients during cystoscopy with suspicion of urothelial neoplasia, and for 11 patients with prostatectomy due to cancer. After surgery in the tissue specimen we immediately introduced surgical suture and investigated a bladder wall by CP OCT. When comparing OCT images and histology ... (Read Full Article)

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Russian Academy of Sciences   Valentin M. Gelikonov

  4. Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo

    Explore Article SPIE Digital Library (Feb 16 2009) Dermatology

    Dynamics of nanoparticles penetrating and accumulating in healthy (skin) and pathologically altered (tumor) tissue was investigated in vivo by the method of optical coherence tomography (OCT). Gold nanoshells having the size of 130/15 nm and titanium dioxide nanoparticles 40-100 nm in size were stud ... [Proc. SPIE 7188, 71880L (2009)] published Mon Feb 16, 2009. (Read Full Article)

    Comment on Article Mentions:   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova   Pavel D. Agrba

  5. Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation

    Explore Article Institute of Physics (Aug 17 2008)

    Abstract. The possibility of using silica–gold nanoshells with 150 nm silica core size and 25 nm thick gold shell as contrasting agents for optical coherence tomography (OCT) is analyzed. Experiments on agar biotissue phantoms showed that the penetration of nanoshells into the phantoms increases the intensity of the optical coherence tomography (OCT) signal and the brightness of the corresponding areas of the OCT image. In vivo experiments on rabbit skin demonstrated that the application of nanoshells onto the skin provides significant contrasting of the borders between the areas containing nanoshells and those without. This effect of nanoshells on skin in ... (Read Full Article)

    Comment on Article Mentions:   University of Oulu   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova

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