1. Articles from e. v. zagaynova

    1-11 of 11
    1. Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva

      Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva

      The aim of the study was to test the method of optical coherence tomography (OCT) for its ability to obtain images of blood and lymphatic vessels of the vulva. Materials and Methods. The study was performed using a multimodal optical coherence tomography device developed in the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod). In this setup, 3D images of 3.4×3.4×1.25 mm are created within 26 s. OCT angiography and OCT lymphangiography are based on the speckle structure analysis. Visualization of blood and lymphatic vessels does not require any additional contrast ...

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    2. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24 hours/3–12 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling error and better therapy regimen selection. Post-treatment OCA images at 24 hours were 98% predictive of eventual outcome. Additional findings highlight the importance of pre-treatment necrotic core, vascular ...

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    3. In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography

      In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography

      Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of oropharyngeal and nasopharyngeal cancer using multifunctional optical coherence tomography (OCT). A spectral domain OCT system with a specially-designed oral imaging probe was used. Microvasculature visualization was based on temporal speckle variations of the full complex signal evaluated by high-pass filtering of 3D data along the slow scan axis. Angiographic image ...

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    4. The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy

      The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy

      The aim of the investigation was to evaluate the possibilities for using cross-polarization optical coherence tomography (CP OCT) to monitor the effectiveness of treatment of cancer of the mouth cavity and of the cervix uteri after photodynamic therapy (PDT) and radiation therapy (RT). Materials and Methods. The CP OCT investigation was performed with an OCT-1300U (Institute of Applied Physics of the Russian Academy of Sciences, LLC “Biomedtech”, Russia) tomograph. The monitoring of the two types of treatment was performed after different periods of exposure: for RT of the mouth cavity cancer — once every 2–3 days throughout the whole course ...

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    5. The Development of the Methodology of Monitoring Experimental Tumors Using Multimodal Optical Coherence Tomography: the Choice of an Optimal Tumor Model

      The Development of the Methodology of Monitoring Experimental Tumors Using Multimodal Optical Coherence Tomography: the Choice of an Optimal Tumor Model

      The objective of the research was to study the features of transplantation, growth and visualization of experimental tumors of animals, using multi-functional optical coherence tomography (OCT) to develop the methodology of evaluation of individual tumor response to anti-cancer therapy. Materials and Methods. The research was carried out using an experimental high-speed spectral-domain multimodal OCT system developed at the Institute of Applied Physics of the Russian Academy of Sciences (Russia). The technical characteristics of the system are the following: speed of information acquisition, 20,000 А-scans per second; 1.3 μm wavelength; frame size, approximately 4×2 mm; lateral resolution, 25 ...

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    6. Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues

      Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues
      In this study, dynamics of nanoparticles penetrating and accumulating in biotissue (healthy skin) was investigated in vivo by the noninvasive method of optical coherence tomography (OCT). Gold nanoshells and titanium dioxide nanoparticles were studied. The processes of the nanoparticles penetration and accumulation in biotissue are accompanied by the changes in optical properties of skin which affect the OCT images. The continuous OCT monitoring of the process of the nanoparticles penetration into skin showed that these changes appeared in 30 min after application of nanoparticles on the surface; the time of accumulation of maximal nanoparticles concentration in skin was observed in ...
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    7. Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia

      Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia
      We consider the cross-polarization OCT (CP OCT) that is focused on comparison of images resulting from cross-polarization and co-polarization scattering simultaneously. This technique provides information about microstructural and biochemical alterations in depolarizing tissue components (collagen). We found that mature type I collagen gives a strong signal in orthogonal polarization. CP OCT images of benign inflammatory processes always feature signal in orthogonal polarization, with layers and borders persisting to be well defined. In the presence of precancerous alterations, signal in orthogonal polarization is available in the image but it is irregular, disappearing in some areas. A CP OCT image of bladder ...
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    8. Compression as a method for increasing the informativity of optical coherence tomography of biotissues

      Compression as a method for increasing the informativity of optical coherence tomography of biotissues
      The efficiency of the mechanical compression of biotissues for improving the differentiation between pathological changes in the structure of a biotissue observed by the method of optical coherence tomography (OCT) is investigated. The effect of the compression in the OCT-images of samples of the human rectum affected by inflammation and carcinoma is studied ex vivo. It is shown that the use of compression makes it possible to differentiate between these pathological changes. To interpret experimental data, images of an inflamed part of rectum are modeled by the Monte Carlo method for different degrees of compression. The results of modeling agree ...
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    9. Cross-polarization endoscopic optical coherence tomography in urology

      Cross-polarization endoscopic optical coherence tomography in urology
      We present results obtained using a two-channel portable device for CP OCT based on the polarization-maintaining fiber. The device is capable of acquiring OCT images of the object in direct and orthogonal polarizations simultaneously. The OCT system has an endoscopic forward-looking probe (2.7 mm in diameter). The CP OCT imaging was done in 64 postoperative specimens, for 30 patients during cystoscopy with suspicion of urothelial neoplasia, and for 11 patients with prostatectomy due to cancer. After surgery in the tissue specimen we immediately introduced surgical suture and investigated a bladder wall by CP OCT. When comparing OCT images and ...
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    10. Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo

      Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo
      Dynamics of nanoparticles penetrating and accumulating in healthy (skin) and pathologically altered (tumor) tissue was investigated in vivo by the method of optical coherence tomography (OCT). Gold nanoshells having the size of 130/15 nm and titanium dioxide nanoparticles 40-100 nm in size were stud ... [Proc. SPIE 7188, 71880L (2009)] published Mon Feb 16, 2009.
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    11. Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation

      Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation
      Abstract. The possibility of using silica–gold nanoshells with 150 nm silica core size and 25 nm thick gold shell as contrasting agents for optical coherence tomography (OCT) is analyzed. Experiments on agar biotissue phantoms showed that the penetration of nanoshells into the phantoms increases the intensity of the optical coherence tomography (OCT) signal and the brightness of the corresponding areas of the OCT image. In vivo experiments on rabbit skin demonstrated that the application of nanoshells onto the skin provides significant contrasting of the borders between the areas containing nanoshells and those without. This effect of nanoshells on skin ...
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    1-11 of 11
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    1. (11 articles) Nizhny Novgorod State Medical Academy
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    Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo Cross-polarization endoscopic optical coherence tomography in urology Compression as a method for increasing the informativity of optical coherence tomography of biotissues Advantages of cross-polarization endoscopic optical coherence tomography in diagnosis of bladder neoplasia Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues The Use of Cross-Polarization OCT in Determining the Dynamics of the State of Pathological and Normal Tissues During Radiation and Photodynamic Therapy The Development of the Methodology of Monitoring Experimental Tumors Using Multimodal Optical Coherence Tomography: the Choice of an Optimal Tumor Model In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea