1. Articles from Victor L. Perez

    1-11 of 11
    1. Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases

      Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases

      Purpose Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and differentiation of OSSN within coexisting ocular surface pathologies. Methods Retrospective study of 16 patients with ocular surface disease and lesions suspicious for OSSN that were evaluated with HR-OCT. HR-OCT images of the lesions were taken to look for evidence of OSSN. Biopsies were performed in all cases, and the HR-OCT findings were compared to the histological results. Results Of the 16 ...

      Read Full Article
    2. Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis

      Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis

      PURPOSE: To evaluate the anterior keratoprosthesis-cornea interface in eyes with Boston type I keratoprosthesis (Kpro). METHODS: In a prospective non-interventional study, patients with Boston type I Kpro underwent ultra-high resolution optical coherence tomography (UHR-OCT) evaluation. The images were used to measure and describe characteristics of the anterior keratoprosthesis-cornea interface, epithelial interaction at the keratoprosthesis edge and the keratoprosthesis-cornea interface gap. RESULTS: Ten patients including 4 male and 6 female subjects with different preoperative diagnoses, i.e. 8 multiple corneal graft failures and 2 immunological ocular surface diseases, were studied. Mean age was 62.1 ± 20.0 (range, 33.0-83.0 ...

      Read Full Article
    3. Optical coherence contrast imaging using gold nanorods in living mice eyes

      Optical coherence contrast imaging using gold nanorods in living mice eyes

      Background Optical Coherence Tomography (OCT) is a powerful imaging modality to visualize tissue structures, with axial image pixel resolution as high as 1.6 um in tissue. However, OCT is intrinsically limited to providing structural information as the OCT contrast is produced by optically scattering tissues. Methods Here we demonstrate gold nanorods (GNRs) injected into the anterior chamber (AC) and cornea of mice eyes can create a significant OCT signal and hence can be used as a contrast agent for in vivo OCT imaging. Results We show that a low dose of 30 nM of GNRs (13 nm in diameter ...

      Read Full Article
    4. Diagnosis of Ocular Surface Lesions Using Ultra–High-Resolution Optical Coherence Tomography

      Diagnosis of Ocular Surface Lesions Using Ultra–High-Resolution Optical Coherence Tomography

      Purpose To assess the use of ultra–high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions. Design Prospective, noncomparative, interventional case series. Participants Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions. Intervention Ultra–high-resolution OCT imaging of the ocular surface lesions. Main Outcome Measures Clinical course and photographs, UHR OCT image, and histopathologic findings. Results Ultra–high-resolution OCT images of all ...

      Read Full Article
    5. Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment

      Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment

      Purpose: This study was designed to determine the ability of ultra-high-resolution optical coherence tomography (UHR-OCT) to monitor tear meniscus volume after dry eye treatment with Restasis® (0.05% cyclosporine). Methods: UHR-OCT was used to image the upper and lower tear menisci (height and volume) in 14 consecutive dry eye patients at baseline. The treatment group was initiated on daily Restasis and measurements were repeated at 1 and 2 months while on treatment. All measurements were performed immediately after a blink. Results: The baseline tear meniscus volumes were 0.40 ± 0.19 µL (upper) and 0.43 ± 0.18 µL (lower ...

      Read Full Article
    6. Visualization of the Precorneal Tear Film Using Ultrahigh Resolution Optical Coherence Tomography in Dry Eye

      Visualization of the Precorneal Tear Film Using Ultrahigh Resolution Optical Coherence Tomography in Dry Eye

      Purpose: To visualize the precorneal tear film (PCTF) in dry eye patients using ultrahigh resolution optical coherence tomography (UHR-OCT). Methods: A custom-built UHR-OCT with ultrahigh resolution (~3 [mu]m) was used to image the PCTF at the vertical meridian. Eighteen right eyes of 18 previously diagnosed dry eye patients (9 men and 9 women, age, 47.8+/-20.7 years) with aqueous tear deficiency were studied. Images were taken during normal and delayed blinking. The visualized PCTF was measured directly. An indirect calculation was used to obtain the thickness in cases where the PCTF could not be visualized. Results: During ...

      Read Full Article
    7. Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye

      Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye

      Developments in optical coherence tomography (OCT) have expanded its clinical applications for ultra-high resolution imaging of the anterior segment of the human eye. This review presents the latest advances for imaging the anterior segment of the eye using ultra-high resolution OCT (UHR-OCT). Unique applications of UHR-OCT technology in clinical and basic scientific laboratory research are discussed and a summary of the results is provided. The authors focused on the use of UHR-OCT for imaging of tear dynamics, contact lens interactions with the corneal surface, and in vivo histological diagnosis of disorders of the cornea, as well as the future direction ...

      Read Full Article
    8. Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography

      Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography
      Purpose: To report a novel diagnostic technique and a case series of conjunctival and corneal intraepithelial neoplasia (CCIN) diagnosed and followed up using prototype ultra high-resolution (UHR) optical coherence tomography (OCT).Design: Prospective, noncomparative, interventional case series.Participants: Seven eyes of 7 consecutive patients with CCIN treated using topical interferon alfa-2b or 5-fluorouracil and 7 eyes of 6 consecutive patients with history of surgically excised pterygia.Intervention: Ultra high-resolution OCT imaging of the ocular surface at primary diagnosis of CCIN and during the follow-up period until resolution of the lesion. Ultra high-resolution OCT images of sites of excised pterygia also ...
      Read Full Article
    9. Epithelial Ingrowth After Descemet Stripping Automated Endothelial Keratoplasty: Description of Cases and Assessment With Anterior Segment Optical Coherence Tomography

      Epithelial Ingrowth After Descemet Stripping Automated Endothelial Keratoplasty: Description of Cases and Assessment With Anterior Segment Optical Coherence Tomography
      Purpose: To describe 5 cases of epithelial ingrowth after Descemet stripping automated endothelial keratoplasty (DSAEK) and the use of anterior segment optical coherence tomography (AS-OCT) to describe the areas of ingrowth. Methods: Five cases with epithelial ingrowth after DSAEK were examined with commercially available AS-OCT and/or a novel custom-built ultrahigh resolution (UHR) AS-OCT. Argon laser photocoagulation was also used to confirm epithelial ingrowth on the iris surface. Pathological evidence of epithelial ingrowth was noted in an eye that underwent corneoscleral grafting for extensive ingrowth through a fistulous tract. Results: Epithelial ingrowth was solely in the graft-host interface in 1 ...
      Read Full Article
    10. System And Method For Molecular In Vivo Imaging And Theranostics

      System And Method For Molecular In Vivo Imaging And Theranostics

      Systems and methods of characterizing biological tissues are provided. Tn the systems and methods, a first optical coherence tomography ( OCT) image of a selected portion of biological tissues combined with a plurality of nanoparticϊεs is obtained, where the plurality of nanoparticlεs are configured to bind to one or more types of biological molecules in the biological tissues and to produce contrast during OCT imaging. The systems and methods also include estimating a first distribution of the plurality of nanoparticles in the selected portion based on the first OCT image and characterizing the selected portion with respect to the ...

      Read Full Article
    11. Use of Ultra-High-Resolution Optical Coherence Tomography to Detect in Vivo Characteristics of Descemet's Membrane in Fuchs' Dystrophy

      Purpose: To demonstrate the capability of ultra-high-resolution (UHR) anterior segment optical coherence tomography (OCT) to image Descemet's membrane (DM) and measure its thickness in vivo. (2) To evaluate the use of DM characteristics and thickness in the diagnosis of Fuchs' dystrophy.Design: Case-control study.Participants: Twenty eyes of 12 Fuchs' dystrophy patients, 20 eyes of 13 young normal, and 20 eyes of 15 elderly normal subjects.Methods: Subjects were imaged using novel, custom-built UHR-OCT. Images were used to describe the characteristics of DM. Custom-made software was used to measure DM thickness and central corneal thickness (CCT). Specimens of DM ...
      Read Full Article
    1-11 of 11
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (11 articles) University of Miami
    2. (9 articles) Jianhua Wang
    3. (5 articles) Mohamed Abou Shousha
    4. (4 articles) Sander R. Dubovy
    5. (3 articles) Meixiao Shen
    6. (2 articles) Stanford University
    7. (2 articles) Wenzhou Medical College
    8. (2 articles) Qi Chen
    9. (2 articles) Adam de la Zerda
    10. (2 articles) Sonia H. Yoo
    11. (1 articles) Carl Zeiss Meditec
  3. Popular Articles

  4. Picture Gallery

    System And Method For Molecular In Vivo Imaging And Theranostics Epithelial Ingrowth After Descemet Stripping Automated Endothelial Keratoplasty: Description of Cases and Assessment With Anterior Segment Optical Coherence Tomography Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye Visualization of the Precorneal Tear Film Using Ultrahigh Resolution Optical Coherence Tomography in Dry Eye Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment Diagnosis of Ocular Surface Lesions Using Ultra–High-Resolution Optical Coherence Tomography Optical coherence contrast imaging using gold nanorods in living mice eyes Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis Non Exudative AMD Imaged With SS-OCT- Extension High space-bandwidth in quantitative phase imaging using partially spatially coherent optical coherence microscopy and deep neural network Optical coherence tomography assessment of macrophages accumulation in non-ST-segment elevation acute coronary syndromes