1. Articles from V. V. Elagin

    1-5 of 5
    1. Multimodal Optical Coherence Tomography in Visualization of Brain Tissue Structure at Glioblastoma (Experimental Study)

      Multimodal Optical Coherence Tomography in Visualization of Brain Tissue Structure at Glioblastoma (Experimental Study)

      The aim of the investigation was to evaluate the performance of multimodal OCT (MM OCT) for differential diagnostics of normal and diseased brain tissue using an experimental model of glioblastoma. Materials and Methods. The spectral domain MM OCT device developed at the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod, Russia) was used for the study. It provides two modes of investigation: cross-polarization OCT (CP OCT) and microangiographic OCT (MA OCT). The instrument features the following characteristics: rate of information gathering — 20,000 A-scans per second; wavelength — 1.3 µm; shot size — ~4 × 2 mm; lateral ...

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    2. The Development of the Methodology of Monitoring Experimental Tumors Using Multimodal Optical Coherence Tomography: the Choice of an Optimal Tumor Model

      The Development of the Methodology of Monitoring Experimental Tumors Using Multimodal Optical Coherence Tomography: the Choice of an Optimal Tumor Model

      The objective of the research was to study the features of transplantation, growth and visualization of experimental tumors of animals, using multi-functional optical coherence tomography (OCT) to develop the methodology of evaluation of individual tumor response to anti-cancer therapy. Materials and Methods. The research was carried out using an experimental high-speed spectral-domain multimodal OCT system developed at the Institute of Applied Physics of the Russian Academy of Sciences (Russia). The technical characteristics of the system are the following: speed of information acquisition, 20,000 А-scans per second; 1.3 μm wavelength; frame size, approximately 4×2 mm; lateral resolution, 25 ...

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    3. Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry

      Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry

      Local laser hyperthermia of grafted RShM-5 tumors in mice with the use of plasmon resonant gold nanoparticles has been carried out. Accumulation of particles in the tumor was monitored in vivo noninvasively by optical coherence tomography. Thereby it was determined that the maximal content of nanoparticles in the tumor was reached within 5 h after intravenous administration, and laser hyperthermia was performed at this time. Monitoring the tumor temperature during the treatment by IR thermography and acoustic thermometry showed that the nanoparticles provided efficient temperature elevation inside the tumor as well as more selective heating. Local laser hyperthermia with gold ...

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    4. Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues

      Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues
      In this study, dynamics of nanoparticles penetrating and accumulating in biotissue (healthy skin) was investigated in vivo by the noninvasive method of optical coherence tomography (OCT). Gold nanoshells and titanium dioxide nanoparticles were studied. The processes of the nanoparticles penetration and accumulation in biotissue are accompanied by the changes in optical properties of skin which affect the OCT images. The continuous OCT monitoring of the process of the nanoparticles penetration into skin showed that these changes appeared in 30 min after application of nanoparticles on the surface; the time of accumulation of maximal nanoparticles concentration in skin was observed in ...
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    5. Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor

      Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor
      The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When the accumulation of nanoparticles in the tumor was maximal, hyperthermia was accomplished using the LSP-AZOR laser setup generating cw radiation at 810 nm. The duration of exposition was 20 min ...
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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Institute of Applied Physics
    2. (5 articles) Nizhny Novgorod State Medical Academy
    3. (4 articles) Elena V. Zagaynova
    4. (2 articles) Mikhail Y. Kirillin
    5. (2 articles) Natalia D. Gladkova
    6. (2 articles) Pavel D. Agrba
    7. (2 articles) Vladislav A. Kamensky
    8. (2 articles) Maria M. Karabut
    9. (1 articles) University of Toronto
    10. (1 articles) Elena B. Kiseleva
    11. (1 articles) Duke University
    12. (1 articles) Adam Wax
    13. (1 articles) Hrebesh M. Subhash
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