1. Articles from guillermo tearney

    1-13 of 13
    1. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter, deployed during endoscopy. In this paper, we present a TCE device that scans and targets the imaging beam using a low-cost stepper motor that is integrated inside the capsule. In ...

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    2. Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

      Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging

      An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first waveguide receives the first radiation, and the second waveguide receives the second radiation. The first arrangement, the second arrangement and the configuration can be housed in a probe.

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    3. In-line optical fiber metallic mirror reflector for monolithic common path optical coherence tomography probes

      In-line optical fiber metallic mirror reflector for monolithic common path optical coherence tomography probes

      Background and Objectives Endoscopic optical coherence tomography probes suffer from various artifacts due to dispersion imbalance and polarization mismatch between reference and sample arm light. Such artifacts can be minimized using a common path approach. In this work, we demonstrate a miniaturized common path probe for optical coherence tomography using an inline fiber mirror. Materials and Methods A common path optical fiber probe suitable for performing high-resolution endoscopic optical coherence tomography imaging was developed. To achieve common path functionality, an inline fiber mirror was fabricated using a thin gold layer. A commercially available swept source engine was used to test ...

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    4. Astigmatism corrected common path probe for optical coherence tomography

      Astigmatism corrected common path probe for optical coherence tomography

      Background and Objectives Optical coherence tomography (OCT) catheters for intraluminal imaging are subject to various artifacts due to reference-sample arm dispersion imbalances and sample arm beam astigmatism. The goal of this work was to develop a probe that minimizes such artifacts. Materials and Methods Our probe was fabricated using a single mode fiber at the tip of which a glass spacer and graded index objective lens were spliced to achieve the desired focal distance. The signal was reflected using a curved reflector to correct for astigmatism caused by the thin, protective, transparent sheath that surrounds the optics. The probe design ...

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    5. Comparative Diagnostic Performance of Volumetric Laser Endomicroscopy and Confocal Laser Endomicroscopy in the Detection of Dysplasia Associated with Barrett’s Esophagus

      Comparative Diagnostic Performance of Volumetric Laser Endomicroscopy and Confocal Laser Endomicroscopy in the Detection of Dysplasia Associated with Barrett’s Esophagus

      Background & Aims Probe-based confocal laser endomicroscopy (pCLE) and volumetric laser endomicroscopy (VLE) are advanced endoscopic imaging modalities that may be useful in the diagnosis of dysplasia associated with Barrett’s esophagus (BE). We performed pCLE examination in ex-vivo endoscopic mucosal resection (EMR) specimens and compared the diagnostic performance of using the current VLE scoring index (OCT-SI) and a novel VLE diagnostic algorithm (VLE-DA) for the detection of dysplasia. Methods 27 patients with BE enrolled in a surveillance program at a tertiary center underwent 50 clinically indicated EMRs that were imaged with VLE and pCLE and classified into neoplastic (N=34 ...

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    6. Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Background Volumetric laser endomicroscopy (VLE) produces high-resolution, cross-sectional surface, and subsurface images for detecting neoplasia, targeting biopsies, and guiding real-time treatment. Objective To evaluate the safety and feasibility of the Nvision VLE system. Design Prospective, multicenter study. Setting Tertiary-care medical centers. Patients One hundred patients with suspected Barrett’s esophagus, including 52 patients with prior endotherapy. Interventions The first-generation Nvision VLE Imaging System, a balloon-centered, rotating optical probe provided images of the mucosa and submucosa through a 6-cm segment length and 360° scan of the distal esophagus. Main Outcome Measurements Acquisition of a complete, 6-cm scan from the distal esophagus ...

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    7. Common Path Side Viewing Monolithic Ball Lens Probe for Optical Coherence Tomography

      Common Path Side Viewing Monolithic Ball Lens Probe for Optical Coherence Tomography

      Common path probes are highly desirable for optical coherence tomography as they reduce system complexity and cost by eliminating the need of dispersion compensation and polarization controlling optics. In this work, we demonstrate a monolithic ball lens based, common path, side viewing probe that is suitable for Fourier domain optical coherence tomography. The probe design parameters were simulated in Zemax modeling software and the simulated performance parameters were compared with experimental results. We characterized the performance of the probe by measuring its collection efficiency, resolution, and sensitivity. Our results demonstrated that with a source input power of 25 mW, we ...

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    8. Interobserver Agreement for the Detection of Barrett’s Esophagus with Optical Frequency Domain Imagin

      Interobserver Agreement for the Detection of Barrett’s Esophagus with Optical Frequency Domain Imagin

      Background Optical frequency domain imaging (OFDI) is a second-generation form of optical coherence tomography (OCT) providing comprehensive cross-sectional views of the distal esophagus at a resolution of ~7 μm. Aim Using validated OCT criteria for squamous mucosa, gastric cardia mucosa, and Barrett’s esophagus (BE), the objective of this study was to determine the inter- and intra-observer agreements by a large number of OFDI readers for differentiating these tissues. Methods OFDI images were obtained from nine subjects undergoing screening and surveillance for BE. Sixty-four OFDI image regions of interest were randomly selected for review. A training set of 19 images ...

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    9. Fiber optic imaging endoscope interferometer with at least one faraday rotator

      Fiber optic imaging endoscope interferometer with at least one faraday rotator
      An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single ...
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    10. Interferometeric imaging with a grating based phase control optical delay line

      An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the ...
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    11. Grating based phase control optical delay line

      An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the ...
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    12. Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope

      Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
      An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single ...
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    13. Grating based phase control optical delay line

      An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the ...
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    1-13 of 13
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    1. (13 articles) Guillermo J. Tearney
    2. (8 articles) Massachusetts General Hospital
    3. (8 articles) Harvard University
    4. (6 articles) Brett E. Bouma
    5. (5 articles) Massachusetts Institute of Technology
    6. (5 articles) James G. Fujimoto
    7. (2 articles) Michalina J. Góra
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    Fiber optic imaging endoscope interferometer with at least one faraday rotator Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope Interobserver Agreement for the Detection of Barrett’s Esophagus with Optical Frequency Domain Imagin Common Path Side Viewing Monolithic Ball Lens Probe for Optical Coherence Tomography Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos) Comparative Diagnostic Performance of Volumetric Laser Endomicroscopy and Confocal Laser Endomicroscopy in the Detection of Dysplasia Associated with Barrett’s Esophagus Astigmatism corrected common path probe for optical coherence tomography Evaluation of Age-related Skin Changes and Instrument Reliability Using Clinical Probe Measurements and Imaging Modalities HP-OCT™ wins Victorian AEEA award – nominated for Sir William Hudson award Postdoctoral Scholar in High Resolution Retinal Imaging at The Ohio State University Cone Photoreceptor Integrity assessed with Adaptive Optics Imaging after Laser-Pointer-Induced Retinal Injury Quantitative assessment of macular microvasculature and radial peripapillary capillary plexus in the fellow eyes of patients with retinal vein occlusion using OCT angiography