1. Articles from mark brezinski

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    1. Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability

      Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability

      It is a widely believed paradigm that intimal angiogenesis in coronary atherosclerosis contributes to plaque instability through both hemorrhagic plaque expansion and cholesterol deposition. 1 However, this article supports an alternative concept in which angiogenesis is actually essential for plaque stabilization and healing. 2 , 3 The prevailing paradigm has its origins primarily in histopathology work from the 1980s by Barger’s group reported by Kamat et al. 4 We argue that misinterpretation of their results has skewed the understanding of vulnerable plaque for >35 years. This misconception still endures in recent plaque angiogenesis reviews, affecting understanding of acute coronary syndromes ...

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    2. Determination of a material characteristic with the use of second-order photon correlation

      Determination of a material characteristic with the use of second-order photon correlation

      An optical system and method for characterizing an object is provided. The system includes at least one light source configured to direct photons toward an object and an interferometer configured to receive photons from the object. The system also includes at least one detector system adapted to detect an optical signal at an output of the interferometer and to remove, from the detected optical signal, a signal portion representing first order photon correlations, when present. The system also includes a processor configured to receive data relating to second-order correlated photons from said at least one detector system, each photon or ...

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    3. Serving unmet needs with OCT Webcast with Dr. Mark Brezinski

      Serving unmet needs with OCT Webcast with Dr. Mark Brezinski

      To view this webcast click HERE . This webcast was originally broadcast on July 16, 2015 and is now available for on demand viewing. What Steve Jobs referred to as “the unmet need” is a barrier to effective treatment, scientific discovery—and equipment sales. Traditionally, developers (engineers) strive for precision, elegance, and maximum theoretical performance (e.g. resolution), whereas the end user (physician or researcher) often has very different requirements. Unfortunately, efforts to bridge this gap can easily become confused. In this webcast, biophotonics pioneer Mark Brezinski MD explores unmet needs in biomedicine, using examples in OCT to illustrate how developers ...

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    4. Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques

      Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques

      Serious concerns exist about the Review by Otsuka et al . (Clinical classification of plaque morphology in coronary disease. Nat. Rev. Cardiol. 11, 379–389; 2014 ), 1 some of which are discussed in this Correspondence. The concerns are predominately about the authors' understanding of the principles and application of optical coherence tomography (OCT),

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    5. Nonlocal Quantum Correlations: Beyond Entanglement

      Nonlocal Quantum Correlations: Beyond Entanglement

      The utilization and control of nonlocal quantum interactions is an area of active investigation. This is not limited to subatomic structures but extends to the macroscopic level. Nonlocal interactions can be from either entanglement or path indistinguishability (the path integral for larger systems), with the latter being further subdivided as discussed. These two distinct phenomenon have recently been treated often in the literature as essentially identical, which is problematic when utilizing them for practical applications. The confusion may lie in misunderstanding the physics of the type II spontaneous parameteric downconversion source (SPDS), which is used extensively with entanglement studies. This ...

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    6. Comparison of artifact generation with catheter bending using different PS-OCT approaches

      Comparison of artifact generation with catheter bending using different PS-OCT approaches
      Optical coherence tomography (OCT) is a promising biomedical imaging tool for detecting pathology at a micron scale. In addition to performing structural imaging, other adjuvant techniques are available with OCT. In particular, polarization-sensitive optical coherence tomography (PS-OCT) can be used, either through a single or dual detector approach, to assess collagen concentration and organization. In this paper, we compare the ability of single and dual detector PS-OCT with respect to catheter bending artifacts. It was found that even severe catheter bending resulted in no significant difference in quantitative birefringence measurement with the single detector approach. However, when the dual detector ...
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    7. Fiber optic needle probes for optical coherence tomography imaging

      Fiber optic needle probes for optical coherence tomography imaging

      A fiber optic needle probe for measuring or imaging the internal structure of a specimen includes a needle defining a bore, an optical fiber substantially positioned within the bore, and a beam director in optical communication with the optical fiber. At least a portion of the wall of the needle is capable of transmitting light. The beam director directs light from the optical fiber to an internal structure being imaged and receives light from the structure through a transparent portion of the wall. An actuating device causes motion of any, or all of, the needle, optical fiber, and beam director ...

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    8. Fiber optic imaging endoscope interferometer with at least one faraday rotator

      Fiber optic imaging endoscope interferometer with at least one faraday rotator
      An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single ...
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    9. Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope

      Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
      An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single ...
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    1-9 of 9
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  2. Topics in the News

    1. (9 articles) Mark E. Brezinski
    2. (4 articles) Brigham and Women’s Hospital
    3. (4 articles) Massachusetts Institute of Technology
    4. (3 articles) Eric A. Swanson
    5. (3 articles) James G. Fujimoto
    6. (3 articles) Stephen A. Boppart
    7. (2 articles) Harvard University
    8. (2 articles) Guillermo J. Tearney
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    11. (1 articles) University of Pennsylvania
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    Fiber optic needle probes for optical coherence tomography imaging Fiber optic imaging endoscope interferometer with at least one faraday rotator Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope Comparison of artifact generation with catheter bending using different PS-OCT approaches Nonlocal Quantum Correlations: Beyond Entanglement Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques Serving unmet needs with OCT Webcast with Dr. Mark Brezinski Determination of a material characteristic with the use of second-order photon correlation Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability Combining Deep Learning With Optical Coherence Tomography Imaging to Determine Scalp Hair and Follicle Counts Efficacy and Safety of Laser‐Assisted Combination Chemotherapy: An Explorative Imaging‐Guided Treatment With 5‐Fluorouracil and Cisplatin for Basal Cell Carcinoma A NOVEL FINDING OF HYPERREFLECTIVE MATERIAL IN THE SILICONE-RETINA INTERFACE: An Optical Coherence Tomographic and Histopathological Study