1. Articles from david r. williams

    1-8 of 8
    1. Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye

      Cellular-scale evaluation of induced photoreceptor degeneration in the living primate eye

      Progress is needed in developing animal models of photoreceptor degeneration and evaluating such models with longitudinal, noninvasive techniques. We employ confocal scanning laser ophthalmoscopy, optical coherence tomography (OCT) and high-resolution retinal imaging to noninvasively observe the retina of non-human primates with induced photoreceptor degeneration. Photoreceptors were imaged at the single-cell scale in three modalities of adaptive optics scanning light ophthalmoscopy: traditional confocal reflectance, indicative of waveguiding; a non-confocal offset aperture technique visualizing scattered light; and two-photon excited fluorescence, the time-varying signal of which, at 730 nm excitation, is representative of visual cycle function. Assessment of photoreceptor structure and function using ...

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    2. Imaging and Measurement in the Eye: Now and Ahead

      Imaging and Measurement in the Eye: Now and Ahead

      Nearly all the eye's structures, from the retina at the back of the eye to the tear film at the front, can now be imaged and measured in vivo with outstanding resolution and precision. Imaging and measurement of the eye is fundamental to both research and clinical practice in optometry, and the technologies to do this have mushroomed exponentially in recent decades. The capabilities of these current imaging technologies are most impressive, allowing the visualization of the fine structure of the eye that was not conceivable 20 years ago. From the observation of corneal nerve fibers and epithelial cells ...

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    3. Imaging single cells in the living retina

      Imaging single cells in the living retina

      A quarter century ago, we were limited to a macroscopic view of the retina inside the living eye. Since then, new imaging technologies, including confocal scanning laser ophthalmoscopy, optical coherence tomography, and adaptive optics fundus imaging, transformed the eye into a microscope in which individual cells can now be resolved noninvasively. These technologies have enabled a wide range of studies of the retina that were previously impossible.

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    4. Method and apparatus for improving vision and the resolution of retinal images

      A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which ...

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    5. Method and apparatus for improving vision and the resolution of retinal images

      A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which ...

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    6. Method and apparatus for improving vision and the resolution of retinal images

      A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which ...

      Read Full Article
    7. Method and apparatus for improving vision and the resolution of retinal images

      A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which ...

      Read Full Article
    8. Method and apparatus for improving vision and the resolution of retinal images

      A method of and apparatus for improving vision and the resolution of retinal images is described in which a point source produced on the retina of a living eye by a laser beam is reflected from the retina and received at a lenslet array of a Hartmann-Shack wavefront sensor such that each of the lenslets in the lenslet array forms an aerial image of the retinal point source on a CCD camera located adjacent to the lenslet array. The output signal from the CCD camera is acquired by a computer which processes the signal and produces a correction signal which ...

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    1-8 of 8
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  2. Topics in the News

    1. (8 articles) University of Rochester
    2. (8 articles) David R. Williams
    3. (1 articles) University of Tübingen
    4. (1 articles) Nicolaus Copernicus University
    5. (1 articles) University of Pittsburgh
    6. (1 articles) Maciej Wojtkowski
    7. (1 articles) UC Davis
    8. (1 articles) Robert J. Zawadzki
    9. (1 articles) Mehdi Azimipour
    10. (1 articles) John S. Werner
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