1. Articles from jungtae rha

    1-9 of 9
    1. High-Resolution Images of Retinal Structure in Patients with Choroideremia

      High-Resolution Images of Retinal Structure in Patients with Choroideremia

      Purpose. To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. Methods. Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-field electroretinography, and fundus autofluorescence (FAF). High-resolution macular images were obtained with adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography (SD-OCT). Coding regions of the CHM gene were sequenced. Results. Molecular analysis of the CHM gene identified a deletion of exons 9 to 15 in family A, a splice site mutation at position 79+1 of ...

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    2. Adaptive Optics and Spectral-Domain Optical Coherence Tomography of Human Photoreceptor Structure After Short Pascal Macular Grid and Panretinal Laser Photocoagulation [Research Letters]

      Adaptive Optics and Spectral-Domain Optical Coherence Tomography of Human Photoreceptor Structure After Short Pascal Macular Grid and Panretinal Laser Photocoagulation [Research Letters]

      To understand the effect of therapeutic doses of laser application on the neurosensory retina, detailed histologic1-3 and optical coherence tomographic (OCT)4-10 evaluations have been used in both animal models and the human eye. We sought to evaluate photoreceptor structure associated with laser photocoagulation lesions using 2 high-resolution retinal imaging tools: adaptive optics (AO) and spectral-domain OCT (SD-OCT). Methods Two patients received short-duration (20-millisecond) Pascal laser therapy (532 nm; OptiMedica Corp) for clinical indications. Subject 1 was a 57-year-old woman with macular edema from hemicentral retinal vein occlusion. Treatment consisted of 3 x 3 grid laser applications with a 100-μm ...

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      Mentions: Abbot
    3. Assessing the Photoreceptor Mosaic over Drusen Using Adaptive Optics and SD-OCT

      Assessing the Photoreceptor Mosaic over Drusen Using Adaptive Optics and SD-OCT

      Drusen are extracellular deposits that accumulate between the retinal pigment epithelium and Bruch’s membrane. They are one of the earliest clinical manifestations of age-related macular degeneration and it is thought that they disrupt the overlying photoreceptors, leading to subsequent vision loss. The purpose of this study was to illustrate how spectral domain optical coherence tomography and adaptive optics fundus imaging can be used to quantitatively analyze the integrity of the overlying photoreceptors in a single subject with macular drusen. This imaging approach and the image analysis metrics introduced may serve as the foundation for valuable imaging-based biomarkers for detecting ...

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    4. Spectral Domain Optical Coherence Tomography and Adaptive Optics: Imaging Photoreceptor Layer Morphology to Interpret Preclinical Phenotypes

      Spectral Domain Optical Coherence Tomography and Adaptive Optics: Imaging Photoreceptor Layer Morphology to Interpret Preclinical Phenotypes

      Recent years have seen the emergence of advances in imaging technology that enable in vivo evaluation of the living retina. Two of the more promising techniques, spectral domain optical coherence tomography (SD-OCT) and adaptive optics (AO) fundus imaging provide complementary views of the retinal tissue. SD-OCT devices have high axial resolution, allowing assessment of retinal lamination, while the high lateral resolution of AO allows visualization of individual cells. The potential exists to use one modality to interpret results from the other. As a proof of concept, we examined the retina of a 32 year-old male, previously diagnosed with a red-green ...

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    5. Unusual Adaptive Optics Findings in a Patient With Bilateral Maculopathy

      Unusual Adaptive Optics Findings in a Patient With Bilateral Maculopathy

      Over the past decade there has been a rapid evolution in our ability to noninvasively image the living human retina. Of particular interest is adaptive optics (AO), a technique that corrects for the eye's monochromatic aberrations and allows nearly diffraction-limited imaging of the retina.1 There is increasing clinical application of AO imaging2-5 owing to the ability to resolve retinal pathological changes on a cellular level, although the future of AO imaging for clinical diagnosis is not clear. Of particular value in determining the potential diagnostic role of AO are cases in which the standard clinical picture is unclear ...

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    6. Spectral-Domain Optical Coherence Tomography and Adaptive Optics May Detect Hydroxychloroquine Retinal Toxicity Before Symptomatic Vision Loss

      Spectral-Domain Optical Coherence Tomography and Adaptive Optics May Detect Hydroxychloroquine Retinal Toxicity Before Symptomatic Vision Loss

      Purpose: To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity. Methods: Two patients with long-term hydroxychloroquine use, subtle perifoveal ophthalmoscopic pigmentary changes, and bilateral perifoveal defects on automated Humphrey visual field (HVF) 10-2 perimetry were imaged using SD-OCT and AO. Results: SD-OCT images demonstrated loss of photoreceptor inner segment/outer segment (IS/OS) junction and a downward “sink-hole” displacement of inner retinal structures in areas of hydroxychloroquine toxicity corresponding to HVF 10-2 defects and ophthalmoscopic clinical examination findings. SD-OCT irregularities in the IS/OS junction were also seen in areas not detected on ...

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    7. Variable optical activation of human cone photoreceptors visualized using a short coherence light source

      Variable optical activation of human cone photoreceptors visualized using a short coherence light source
      It has been shown that after a visible stimulus, optical oscillations of nearly all cone photoreceptors can be observed using long coherence length light and in a few cones using short coherence length light. Here, we show that after exposure to a visible stimulus, a short coherence length imaging source reveals light-evoked oscillation signals in a large number of cones. More than 80% of cones in a given retinal area are activated (modulation in the reflectance signal) after stimulation, and the pattern of their activation can be subjectively classified into one of four categories. The application of light-evoked signal detection ...
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    8. Retinal Imaging Using Commercial Broadband Optical Coherence Tomography

      Aims: To examine the practical improvement in image quality afforded by a broadband light source in a clinical setting and to define image quality metrics for future use in evaluating spectral domain optical coherence tomography (SD-OCT) images. Methods: A commercially available SD-OCT system, configured with a standard source as well as an external broadband light source was used to acquire 4mm horizontal line scans of the right eye of 10 normal subjects. Scans were averaged to reduce speckling and multiple retinal layers were analyzed in the resulting images. Results: For all layers a significant improvement in the mean local contrast ...

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    9. In vivo functional imaging of humancone photoreceptors

      We evaluate a novel non-invasive optical technique for observing fast physiological processes, in particular phototransduction, in single photoreceptor cells in the living human eye. The method takes advantage of the interference of multiple reflections within the outer segments (OS) of cones. ... [Opt. Express 15, 16141-16160 (2007)]

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    1-9 of 9
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    Spectral-Domain Optical Coherence Tomography and Adaptive Optics May Detect Hydroxychloroquine Retinal Toxicity Before Symptomatic Vision Loss Unusual Adaptive Optics Findings in a Patient With Bilateral Maculopathy Variable optical activation of human cone photoreceptors visualized using a short coherence light source Spectral Domain Optical Coherence Tomography and Adaptive Optics: Imaging Photoreceptor Layer Morphology to Interpret Preclinical Phenotypes Assessing the Photoreceptor Mosaic over Drusen Using Adaptive Optics and SD-OCT Adaptive Optics and Spectral-Domain Optical Coherence Tomography of Human Photoreceptor Structure After Short Pascal Macular Grid and Panretinal Laser Photocoagulation [Research Letters] High-Resolution Images of Retinal Structure in Patients with Choroideremia The Structural and Comparative Analysis of Intravitreal Dexamethasone Implant (Ozurdex) and Anti-VEGF Injection in Branched Retinal Vein Occlusion Patients by Optical Coherence Tomography Angiography Images Quantitation Vascular Responses to First-Generation Sirolimus-Eluting Stents and Bare-Metal Stents Beyond 10 Years Ocular Parameters Evaluation in Relation to the Refractive Error using Optical Coherence Topography Micro Optical Coherence Tomography for Coronary Imaging Macular Vessel Density in Diabetic Retinopathy Patients: How Can We Accurately Measure and What Can It Tell Us?