1. Articles from Shanhui Fan

    1-9 of 9
    1. Dual band dual focus optical coherence tomography for imaging the whole eye segment

      Dual band dual focus optical coherence tomography for imaging the whole eye segment

      We developed an improved dual band dual focus spectral domain optical coherence tomography (SD-OCT) for in vivo 2D/3D imaging of the whole eye segment, including the whole anterior segment and retina. The system featured two OCT channels with two different bands centered at 840 nm and 1050 nm, which were designed to image the retina and the anterior segments of the eye, respectively. By combing the two probe light beams for co-axial scanning and separating them for focusing at different segments of the eye with a combination of three dichroic mirrors, we not only minimized the loss of the ...

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    2. PEGylated Aucore–Agshell Nanorods as Optical Coherence Tomography Signal Nanoamplifiers

      PEGylated Aucore–Agshell Nanorods as Optical Coherence Tomography Signal Nanoamplifiers

      Optimizing contrast enhancement in optical coherence tomography (OCT) is essential for producing specific image signals and realizing its potential use in various biomedical imaging fields besides ophthalmology and cardiology. Using nanoparticles as selective signal nanoamplifiers will be helpful to highlight the lesion sites and identify cancerous changes that are difficult to diagnose currently. In this study, a quantitatively detailed analysis on the improvement of contrast enhancement and penetration depth of Au core –Ag shell nanorods (Au@Ag NRs) as OCT contrast agent was performed. The average A-scan data of the tissue was extracted and investigated. The signal to noise ratio ...

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    3. Whole Eye Segment Imaging and Measurement With Dual-Channel Spectral-Domain OCT

      Whole Eye Segment Imaging and Measurement With Dual-Channel Spectral-Domain OCT

      BACKGROUND AND OBJECTIVES: To image and measure whole eye segments using dual-channel spectral-domain optical coherence tomography (SD-OCT) and to compare the results with those from the IOLMaster (Carl Zeiss Meditec, Dublin, CA). PATIENTS AND METHODS: Twenty eyes of 20 volunteers were recruited. Ocular dimensions, including cornea thickness, anterior chamber depth (ACD), lens thickness, anterior lens surface curvature, and axial length (AL), were calculated. The reproducibility of SD-OCT measurements, statistical significance of inter-instrument difference, correlation, and agreement were evaluated. RESULTS: No significant differences were found between independent SD-OCT measurements ( P > .05). The ACD and AL measured with IOLMaster were significantly shorter ...

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    4. Dual illumination OCT at 1050nm and 840nm for whole eye segment imaging

      Dual illumination OCT at 1050nm and 840nm for whole eye segment imaging

      We presented an improved dual channel dual focus spectral domain optical coherence tomography (SD-OCT) with two illuminations at 840 nm and 1050 nm for whole eye segment imaging and biometry in vivo. The two light beams were coupled and optically optimized to scan the anterior and posterior segment of the eye simultaneously. This configuration with dichroic mirrors integrated in the sample arm enables us to acquire images from the anterior segment and retina effectively with minimum loss of sample signal. In addition, the full resolved complex (FRC) method was applied to double the imaging depth for the whole anterior segment ...

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    5. Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography

      Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography

      To research retinal stretching or distortion with accommodation, accommodation-induced changes in retinal thickness (RT) in the macular area were investigated in a population of young adults ( n = 23 ) by using a dual-channel spectral domain optical coherence tomography (SD-OCT) system manufactured in-house for this study. This dual-channel SD-OCT is capable of imaging the cornea and retina simultaneously with an imaging speed of 24 kHz A-line scan rate, which can provide the anatomical dimensions of the eye, including the RT and axial length. Thus, the modification of the RT with accommodation can be calculated. A significant decrease in the RT ( 13.50 ...

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    6. Dual-channel spectral-domain optical-coherence tomography system based on 3 × 3 fiber coupler for extended imaging range

      Dual-channel spectral-domain optical-coherence tomography system based on 3 × 3 fiber coupler for extended imaging range

      We have demonstrated a dual-channel multiplexing spectral-domain optical-coherence tomography (SD-OCT) system based on a 3 × 3 fiber coupler for extended imaging range of whole human eye depth, with a single light source and spectrometer. OCT images of anterior segments of a human eye were sequentially performed and constructed to demonstrate an extended depth range as large as 15 mm in air. A good quality OCT image of the whole anterior segment of an eye was present. Furthermore, whole eye segmental imaging was performed and ocular distances were calculated to show the validation of the system for whole eye morphological measurement.

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    7. Noninvasive Imaging and Measurement of Accommodation Using Dual-Channel SD-OCT

      Noninvasive Imaging and Measurement of Accommodation Using Dual-Channel SD-OCT

      Purpose : To investigate the feasibility and practicality of real-time noninvasive imaging and measurement of ocular accommodation (0–5D with one diopter step) using dual-channel , dual-focus spectral domain optical coherence tomography ( SD-OCT ). Materials and Methods : A custom-built, dual-channel , dual-focus SD-OCT was used to image the anterior segment, including the cornea, iris, and anterior and posterior lens surfaces. Three consecutive measurements were taken in each accommodative session for each subject. Changes in ocular dimensions during accommodation were calculated based on the acquired SD-OCT images . A Friedman test was used to test sensitivity of ocular dimension changes per diopter of accommodation . Results : With ...

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    8. Feature Of The Week 3/18/12: Research Results from Shanghai Jiaotong University on Optical Coherence Tomography for Whole Eye Segment Imaging

      Feature Of The Week 3/18/12: Research Results from Shanghai Jiaotong University on Optical Coherence Tomography for Whole Eye Segment Imaging

      Researchers from Shanghai Jiao Tong University, Shanghai Institute of Technology, Peking University, and UCLA recently published a paper on “Optical coherence tomography for whole eye segment imaging". Below is a summary of their work. We proposed a dual focus dual channel spectral domain optical coherence tomography (SD-OCT) for simultaneous imaging of the whole eye segments from cornea to the retina. By using dual channels the system solved the problem of limited imaging depth of SD-OCT. By using dual focus the system solved the problem of simultaneous light focusing on the anterior segment of the eye and the retina. Dual focusing ...

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    9. Optical coherence tomography for whole eye segment imaging

      Optical coherence tomography for whole eye segment imaging

      We proposed a dual focus dual channel spectral domain optical coherence tomography (SD-OCT) for simultaneous imaging of the whole eye segments from cornea to the retina. By using dual channels the system solved the problem of limited imaging depth of SD-OCT. By using dual focus the system solved the problem of simultaneous light focusing on the anterior segment of the eye and the retina. Dual focusing was achieved by adjusting the collimating lenses so the divergence of the two probing beams was tuned to make them focused at different depth in the eye. We further achieved full range complex (FRC ...

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    1-9 of 9
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    1. (9 articles) Shanghai Jiao Tong University
    2. (9 articles) Chuanqing Zhou
    3. (8 articles) Qiushi Ren
    4. (8 articles) Cuixia Dai
    5. (4 articles) Peking University
    6. (4 articles) Shuliang Jiao
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    Optical coherence tomography for whole eye segment imaging Feature Of The Week 3/18/12: Research Results from Shanghai Jiaotong University on Optical Coherence Tomography for Whole Eye Segment Imaging Noninvasive Imaging and Measurement of Accommodation Using Dual-Channel SD-OCT Dual-channel spectral-domain optical-coherence tomography system based on 3 × 3 fiber coupler for extended imaging range Accommodation-induced variations in retinal thickness measured by spectral domain optical coherence tomography Dual illumination OCT at 1050nm and 840nm for whole eye segment imaging Whole Eye Segment Imaging and Measurement With Dual-Channel Spectral-Domain OCT PEGylated Aucore–Agshell Nanorods as Optical Coherence Tomography Signal Nanoamplifiers Dual band dual focus optical coherence tomography for imaging the whole eye segment Factors Associated with Changes in Retinal Layers Following Acute Optic Neuritis: A Longitudinal Study Using Optical Coherence Tomography Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma Historic Effort to 'End Blindness" Marks a Major Milestone with Leading Scientist Recognized for Pioneering Work at VIP Ceremony Featuring Tribute to Ruth Bader Ginsburg