1. Articles from ANDREA GIANI

    1-15 of 15
    1. COMPARISON BETWEEN SEVERAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES AND INDOCYANINE GREEN ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION

      COMPARISON BETWEEN SEVERAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES AND INDOCYANINE GREEN ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION

      Purpose: To compare indocyanine green angiography and four different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of choroidal neovascularization (CNV). Methods: This study was an observational case series of Type 1 and Type 2 CNV presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan, imaged with indocyanine green angiography and four different OCTA devices: prototype PlexElite (Carl Zeiss Meditec), prototype Spectralis OCTA (Spectralis; Heidelberg Engineering, Heidelberg, Germany), Optovue RTVue XR Avanti (Optovue, Inc, Fremont, CA), and AngioPlex (Cirrus 5000 HD-OCT; Carl Zeiss Meditec, Inc, Dublin ...

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    2. Looking Outside The Maculaa Wide-Field Optical Coherence Tomography Study

      Looking Outside The Maculaa Wide-Field Optical Coherence Tomography Study

      Purpose: To evaluate baseline features and morphologic changes of vitreoretinal adhesion and outer retinal layers outside the macula after intravitreal ocriplasmin injection. To study the relation between vitreous detachment and attenuation of retinal outer segments signal. Methods: Retrospective cases series of 15 eyes. Each eye was scanned with the 55° wide-field optical coherence tomography lens in 6 different locations, three horizontal B-scan (central, temporal, and nasal) and three vertical B-scan (central, superior, and inferior) at baseline, 1 week, 1 month, 3 months, and 6 months after injection. Results: After ocriplasmin injection, vitreomacular traction (VMT) resolved in 12 patients (80%), 3 ...

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    3. Reproducibility of vessel density, fractal dimension and foveal avascular zone using 7 different optical coherence tomography angiography devices

      Reproducibility of vessel density, fractal dimension and foveal avascular zone using 7 different optical coherence tomography angiography devices

      Purpose To evaluate the reproducibility of parafoveal microvascular anatomy of 7 different optical coherence tomography angiography (OCT-A) devices by comparing vessels density (VD), fractal dimension (FD) and foveal avascular zone (FAZ) of superficial and deep capillary plexus in healthy volunteers. Design Reliability analysis. Methods Consecutive healthy volunteers presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan in the same clinic visit were imaged by 7 different OCT-A devices: Optovue RTVue XR Avanti (Optovue, Inc, Fremont, CA), prototype Spectralis OCT-A (Spectralis Heidelberg Engineering, Heidelberg, Germany), AngioPlex (Cirrus 5000 HD-OCT, Carl Zeiss Meditec, Inc ...

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    4. Dark Atrophy: An Optical Coherence Tomography Angiography Study

      Dark Atrophy: An Optical Coherence Tomography Angiography Study

      Purpose To assess the status of choriocapillaris in eyes with macular atrophy secondary to age-related macular degeneration (AMD) (geographic atrophy [GA]) and Stargardt disease (STGD) using optical coherence tomography angiography (OCTA). Design Prospective, observational case series. Participants A total of 14 patients (20 eyes) affected by GA and 10 patients (20 eyes) affected by STGD. Methods Each patient underwent a complete ophthalmological examination including fundus autofluorescence (FAF), dynamic simultaneous fluorescein angiography (FA) and indocyanine green angiography (ICGA), enhanced-depth imaging optical coherence tomography (EDI-OCT) (HRA+OCT Spectralis, Heidelberg Engineering, Heidelberg, Germany), and OCTA using AngioVue technologies (Optovue Inc, Freemont, CA). Main ...

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    5. Enhanced Depth Imaging Optical Coherence Tomography Features of Choroidal Osteoma

      Enhanced Depth Imaging Optical Coherence Tomography Features of Choroidal Osteoma

      Purpose: To describe the choroidal findings in eyes affected by choroidal osteoma imaged by enhanced depth imaging optical coherence tomography. Methods: Retrospective case series. Results: Seven eyes from five patients with choroidal osteoma were included in the study. Patients mean age of presentation was 26 years (median, 34; range, 6-37 years) and mean best-corrected visual acuity was 20/32 (median, 20/20; range, 20/20-20/200). Enhanced depth imaging optical coherence tomography examination revealed normal inner retina in all the cases and normal outer retina in three eyes. Abnormalities included irregularities in external limiting membrane (n = 2), myoid zone (n ...

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    6. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography

      Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography

      Purpose: To evaluate differences between the retinal nerve fiber layer (RNFL) thickness and RNFL + ganglion cell layer (GCL) thickness in patients affected by Alzheimer's disease (AD) and healthy patients using spectral-domain optical coherence tomography (SD-OCT). Methods: This was a case-control prospective study. Twenty-one AD patients and 21 healthy subjects underwent neurological examination, clock drawing test (CDT), mini mental state examination (MMSE) and comprehensive ophthalmic evaluation with visual acuity. SD-OCT examination was performed using Spectralis (Heidelberg Engineering, Heidelberg, Germany), and RTVue-100 (Optovue Inc., Freemont, CA, USA). A RNFL thickness map was obtained using the Spectralis volume protocol with 19 lines ...

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    7. Retrobulbar Structure Visualization with Enhanced Depth Imaging Optical Coherence Tomography

      Retrobulbar Structure Visualization with Enhanced Depth Imaging Optical Coherence Tomography

      Purpose: To assess enhanced depth imaging optical coherence tomography (EDI-OCT) visualization of deep posterior pole structures and retrobulbar tissues in myopic eyes and evaluate ocular structural elements that influenced this capability. Methods: Thirty consecutive myopic eyes (>-6 diopters) from 21 patients were enrolled. Exclusion criteria included any pathological condition affecting the posterior pole. Patients underwent biometry to assess axial length, and irises were classified as darkly or lightly pigmented. EDI-OCT scans were obtained by spectral-domain OCT to image posterior pole and retrobulbar structures. Choroidal thickness was measured manually, and for eyes in which the sclera was fully visible, the thickness ...

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    8. Aligning scan locations from consecutive spectral-domain optical coherence tomography examinations: a comparison among different strategies

      Aligning scan locations from consecutive spectral-domain optical coherence tomography examinations: a comparison among different strategies

      Purpose: To compare intrasession repeatability values produced by different spectral-domain optical coherence tomography (SD-OCT) instruments when measuring macular retinal thickness from consecutive examinations. Methods: A total of 40 eyes from 23 healthy subjects and 47 eyes from 42 patients with macular edema were enrolled in the study. Subjects underwent two consecutive SD-OCT examinations using three instruments: Spectralis HRA+OCT (Heidelberg Engineering, Heidelberg, Germany), Cirrus (Carl Zeiss Meditec Inc., Dublin, CA, USA), and RS 3000 (Nidek, Gamagori, Japan). For the second SD-OCT examination, the scan location was aligned to the baseline exam using different strategies: (1) RS 3000 eye-tracking (pre-acquisition), (2 ...

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    9. The natural history of lamellar macular holes: a spectral domain optical coherence tomography study

      The natural history of lamellar macular holes: a spectral domain optical coherence tomography study

      BACKGROUND: To study the evolution of lamellar macular holes (LMHs) using spectral domain-optical coherence tomography (SD-OCT). METHODS: Thirty-four consecutive patients diagnosed with a LMH were followed prospectively at Sacco University Hospital from October 2008 to January 2011. Inclusion criteria were a foveal defect on SD-OCT with residual foveal tissue above the retinal pigment epithelium and corresponding hyperautofluorescence on fundus autofluorescence imaging. Epiretinal membranes (ERMs) were categorized by SD-OCT at baseline as two different types: normal and thicker than normal. Best corrected visual acuity (BCVA) and SD-OCT findings were collected and compared at baseline and every 6 months thereafter. Active eye ...

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    10. Repeatability and Reproducibility of Retinal Thickness Measurements With Spectral-Domain Optical Coherence Tomography Using Different Scan Parameters

      Repeatability and Reproducibility of Retinal Thickness Measurements With Spectral-Domain Optical Coherence Tomography Using Different Scan Parameters

      Purpose: To evaluate repeatability (test-retest) and reproducibility of retinal thickness measurements using spectral-domain optical coherence tomography with different densities of A-scans per B-scan and different frames per B-scan for real-time averaging. Methods: Twelve healthy subjects were analyzed by spectral-domain optical coherence tomography. Raster lines analysis with 19 B-scans over the examined area centered on the macula was performed. Images were acquired both in standard-density (768 A-scans/B-scan) and high-density (1,536 A-scans/B-scan) modalities. Moreover, images were acquired using 2 and 20 frames/B-scan for real-time averaging. Each analysis was repeated twice to test for repeatability. Results: Intersession repeatability was ...

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      Mentions: Andrea Giani
    11. Spectral-Domain Optical Coherence Tomography as an Indicator of Fluorescein Angiography Leakage from Choroidal Neovascularization

      Spectral-Domain Optical Coherence Tomography as an Indicator of Fluorescein Angiography Leakage from Choroidal Neovascularization

      Purpose: To evaluate spectral-domain optical coherence tomography (SD-OCT) findings that predict angiographic leakage in choroidal neovascularization (CNV). Methods: SD-OCT and fluorescein angiography (FA) images of 93 eyes of 93 patients were retrospectively analyzed. All patients were previously treated with anti-vascular endothelial growth factor agents for CNV from age-related macular degeneration. FA images were analyzed to assess the presence of leakage. SD-OCT images were analyzed to identify the overall presence of fluid, as well as specific patterns of fluid presentation including intraretinal cystic spaces (ICS), retinal pigment epithelium detachment (PED), and neurosensory detachment (NSD). The presence of ultrastructural features such as ...

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    12. Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

      Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization
      Purpose The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. Methods CNV lesions were induced in rats using laser photocoagulation. The utility of NP for in vivo imaging and gene delivery was evaluated by coupling the NP with a green fluorescing protein plasmid (NP-GFPg). Rhodamine labeling (Rd-NP) was used to localize NP in choroidal flatmounts. Rd-NP-GFPg particles were injected intravenously on weeks 1, 2, or 3. In the treatment arm, rats received NP containing a ...
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    13. In-vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography

      In-vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography
      Purpose. To describe the in-vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT) Methods. Laser photocoagulation was applied to the mouse fundus using a 532 nm diode-laser (100,150 and 200 mW, 100 μm diameter, 0.1 sec duration). SD-OCT examination was performed immediately after laser application, and at day 3, 5, 7, 14, 21 and 28 after laser. Fluorescein angiography (FA) was performed at day 5, 7, 14 and 28. Acquired SD-OCT images were analyzed to describe morphologic features, measure CNV size and retinal thickness, and assess the frequency of lesions resulting ...
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    14. Reproducibility of Retinal Thickness Measurements on Normal and Pathologic Eyes by Different Optical Coherence Tomography Instruments

      Reproducibility of Retinal Thickness Measurements on Normal and Pathologic Eyes by Different Optical Coherence Tomography Instruments

      Purpose:To compare retinal thickness measurements produced by different time-domain and spectral-domain optical coherence tomography (TD-OCT and SD-OCT) devices when imaging normal and pathologic eyes.Design:Prospective, observational study in an academic institutional setting.Methods:A total of 110 eyes were imaged by 6 different OCT devices: Stratus and Cirrus (Carl Zeiss Meditec Inc), Spectralis HRA+OCT (Heidelberg Engineering), RTVue-100 (Optovue Inc), SDOCT Copernicus HR (Optopol Technology S.A.), and 3D OCT-1000 (Topcon Corporation). Eyes were normal or affected by different pathologies of the retina, including exudative and nonexudative age-related macular degeneration, epiretinal membrane, cystoid macular edema, and macular hole ...

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    15. Artifacts In Automatic Retinal Segmentation Using Different Optical Coherence Tomography Instruments

      Purpose: The purpose of this study was to compare and evaluate artifact errors in automatic inner and outer retinal boundary detection produced by different time-domain and spectral-domain optical coherence tomography (OCT) instruments.Methods: Normal and pathologic eyes were imaged by six different OCT devices. For each instrument, standard analysis protocols were used for macular thickness evaluation. Error frequencies, defined as the percentage of examinations affected by at least one error in retinal segmentation (EF-exam) and the percentage of total errors per total B-scans, were assessed for each instrument. In addition, inner versus outer retinal boundary delimitation and central (1,000 ...

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    1-15 of 15
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    1. (13 articles) Andrea Giani
    2. (11 articles) Giovanni Staurenghi
    3. (10 articles) University of Milan
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    5. (6 articles) Harvard University
    6. (5 articles) Massachusetts Eye and Ear Infirmary
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    Reproducibility of Retinal Thickness Measurements on Normal and Pathologic Eyes by Different Optical Coherence Tomography Instruments In-vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization Spectral-Domain Optical Coherence Tomography as an Indicator of Fluorescein Angiography Leakage from Choroidal Neovascularization Repeatability and Reproducibility of Retinal Thickness Measurements With Spectral-Domain Optical Coherence Tomography Using Different Scan Parameters The natural history of lamellar macular holes: a spectral domain optical coherence tomography study Aligning scan locations from consecutive spectral-domain optical coherence tomography examinations: a comparison among different strategies Retrobulbar Structure Visualization with Enhanced Depth Imaging Optical Coherence Tomography Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography Competency-Based Assessment of Interventional Cardiology Fellows’ Abilities in Intracoronary Physiology and Imaging Real-time, non-contact, cellular imaging and angiography of human cornea and limbus with common-path Full-field/SD OCT In vivo brain imaging with multimodal optical coherence microscopy in a mouse model of thromboembolic photochemical stroke