1. Articles from Gábor Holló

    1-20 of 20
    1. Circumpapillary structure-function relationships with microperimetry and spectral domain optical ...

      Circumpapillary structure-function relationships with microperimetry and spectral domain optical ...

      Purpose: To compare the relationships between circumpapillary microperimetry (MP)-sensitivity measurements and various circumpapillary retinal thickness parameters in healthy and primary open-angle glaucoma (POAG) eyes. Methods: In 14 eyes of 14 healthy subjects and 22 early–moderate POAG eyes of 22 patients, circumpapillary optical coherence tomography thickness measurements (RS-3000 Advance OCT, NIDEK) of the retinal nerve fiber layer (cpRNFL), total retina (cpTR), and ganglion cell complex (cpGCC) and outer retina (cpOR) and circumpapillary MP-sensitivity measurements (MP-3 microperimeter, NIDEK) were made in 12 sectors of identical circumpapillary circles. The structure-function relationship was investigated in each sector. Results: Statistically significant correlations with ...

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    2. Valsalva Maneuver and Peripapillary OCT Angiography Vessel Density

      Valsalva Maneuver and Peripapillary OCT Angiography Vessel Density

      Purpose: To investigate the potential influence of breath holding on the results of peripapillary vessel density (VD) measurement with optical coherence tomography angiography. Materials and Methods: Three peripapillary VD measurements were made at 2-minute intervals on the right eye of 12 healthy young volunteers using the Angiovue/RTvue-XR OCT (software version 2017.1, Phase 7 update) without changing the head and body positions. During the first 2 measurements the volunteers were breathing normally. Four seconds before the third measurement the participants started to perform the Valsalva maneuver and continued until the completion of the ∼17-second image acquisition. The whole image ...

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    3. Managing glaucoma with OCTA

      Managing glaucoma with OCTA

      Optical coherence tomography angiography (OCTA) is a new imaging technique that has the potential to move rapidly into routine clinical practice. OCTA comprises different OCT-based technologies, which enable the non-invasive assessment of retinal perfusion, based on red blood cell movement in the optic nerve head, the peripapillary and the macular retina. In addition to the benefits offered by the non-invasive nature of OCTA over invasive fluorescein angiography in macular diseases, including age-related macular degeneration and diabetic macula oedema, OCTA has been increasingly investigated for use in the detection of glaucoma and understanding the role of vascular alterations in the development ...

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    4. Optical Coherence Tomography Angiography to Better understand Glaucoma

      Optical Coherence Tomography Angiography to Better understand Glaucoma

      The term optical coherence tomography angiography (OCTA) comprises different OCT-based technologies which all allow noninvasive assessment of retinal perfusion, based on moving red blood cells. The main areas where OCTA is currently used are investigation of perfusion and vascular structure of the macular retina (e.g., in macular degenerations and diabetic macular diseases) and the disk and peripapillary retina (in glaucoma and other optic disk diseases). The current editorial provides a brief overview on the potential of OCTA and its use to measure perfusion in the peripapillary retina in glaucoma.

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    5. Relationship Between OCT Angiography Temporal Peripapillary Vessel-Density and Octopus Perimeter Paracentral Cluster Mean Defect

      Relationship Between OCT Angiography Temporal Peripapillary Vessel-Density and Octopus Perimeter Paracentral Cluster Mean Defect

      Purpose of the Study: The purpose of the study was to investigate the relationship between optical coherence tomography angiography angioflow vessel-density (PAFD) measured in the retinal nerve fiber layer in the temporal peripapillary sector and the average of the spatially corresponding superior and inferior paracentral cluster mean defect values (mean paracentral MD) measured with Octopus perimetry. Materials and Methods: Spaerman’s correlation between temporal peripapillary PAFD acquired with the Angiovue OCT and mean paracentral MD measured with the Normal and tendency-oriented perimetry strategy of Octopus G2 perimetry, respectively, was determined on 1 eye of 13 healthy participants, 22 medically controlled ...

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    6. Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values

      Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values

      Purpose To compare the relationship of Octopus perimeter cluster mean-defect (cluster MD) values with the spatially corresponding optical coherence tomography (OCT) sector peripapillary angioflow vessel-density (PAFD) and sector retinal nerve fiber layer thickness (RNFLT) values. Methods High quality PAFD and RNFLT images acquired on the same day with the Angiovue/RTVue-XR Avanti OCT (Optovue Inc., Fremont, USA) on 1 eye of 27 stable early-to-moderate glaucoma, 22 medically controlled ocular hypertensive and 13 healthy participants were analyzed. Octopus G2 normal visual field test was made within 3 months from the imaging. Results Total peripapillary PAFD and RNFLT showed similar strong positive ...

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    7. Influence of Large Intraocular Pressure Reduction on Peripapillary OCT Vessel Density in Ocular Hypertensive and Glaucoma Eyes

      Influence of Large Intraocular Pressure Reduction on Peripapillary OCT Vessel Density in Ocular Hypertensive and Glaucoma Eyes

      Background/Purpose: Optical coherence tomography (OCT) angiography is a new noninvasive method to measure peripapillary microcirculation in various retinal layers, separately. In this case series, we investigate whether large medical intraocular pressure (IOP) reduction (>50% of the untreated baseline value) to IOP<=18 mm Hg influences peripapillary angioflow density (PAFD, percentage of the analyzed retinal area) in the retinal nerve fiber layer in high pressure (IOP>=35 mm Hg) ocular hypertensive and glaucoma eyes. Methods: The AngioVue OCT (software version 2015.100.0.33) was used for PAFD measurements in 6 eyes of 4 consecutive newly detected young patients (age ...

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    8. Evaluation of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex Progression Rates in Healthy, Ocular Hypertensive, and Glaucoma Eyes With the Avanti RTVue-XR Optical Coherence Tomograph Based on 5-Year Follow-up

      Evaluation of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex Progression Rates in Healthy, Ocular Hypertensive, and Glaucoma Eyes With the Avanti RTVue-XR Optical Coherence Tomograph Based on 5-Year Follow-up

      Purpose: To determine retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex (GCC) progression rates for healthy eyes and undertreatment ocular hypertensive (OHT) and glaucoma eyes with the Avanti RTVue-XR optical coherence tomography. Materials and Methods: Seventeen healthy subjects (34 eyes), 17 medically treated OHT patients (34 eyes), and 67 medically treated glaucoma patients (122 eyes) were imaged prospectively at 6-month intervals (median follow-up 5.3 y, 11 visits). Results: A minimal negative correlation between baseline RNFLT and RNFLT progression was found in the glaucoma group (r=-0.1708, P=0.0493). In the other groups no correlation between ...

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    9. Influence of myelinated retinal nerve fibers on retinal vessel density measurement with AngioVue OCT angiography

      Influence of myelinated retinal nerve fibers on retinal vessel density measurement with AngioVue OCT angiography

      Myelinated retinal nerve fibers (MRNF) represent an asymptomatic developmental anomaly in which myelin sheaths extend to a group of retinal nerve fibers along their intraocular portion. The additional volume of the myelin sheaths causes displacement of the axons toward the vitreous body. We investigated the effect of localized MRNF on peripapillary vessel density measurement results using optical coherence tomography (OCT) angiography. Peripapillary angioflow density measurements (PAFD, % of the analyzed retinal area) were made with the AngioVue OCT (Optovue Inc., Fremont, USA). In both cases, the predominant position of MRNF was inferonasal to the disk. Vessel density was clearly greater in ...

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    10. Vessel density calculated from OCT angiography in 3 peripapillary sectors in normal, ocular hypertensive, and glaucoma eyes

      Vessel density calculated from OCT angiography in 3 peripapillary sectors in normal, ocular hypertensive, and glaucoma eyes

      Disturbed peripapillary microcirculation may have a role in the development of glaucoma. Recently, using noninvasive optical coherence tomography (OCT) angiography with the AngioVue OCT (Optovue Inc., ­Fremont, CA, USA), reduced peripapillary vessel density was found in glaucoma. In this case series, we investigate the relationship between retinal nerve fiber layer (RNFL) damage and peripapillary angioflow density (PAFD, % of the analyzed retinal area) in the superotemporal (ST), inferotemporal (IT), and temporal (T) peripapillary sectors in normal, ocular hypertensive (OHT), and primary open-angle glaucoma eyes. The AngioVue OCT and the 2015.100.0.33 software version was used for PAFD measurements. The ...

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    11. Combined use of Doppler OCT and en face OCT functions for discrimination of an aneurysm in the lamina cribrosa from a disc hemorrhage

      Combined use of Doppler OCT and en face OCT functions for discrimination of an aneurysm in the lamina cribrosa from a disc hemorrhage

      In addition to retinal nerve fiber layer thickness measurements, the recently introduced AngioVue optical coherence tomography (OCT) offers corresponding layer-by-layer Doppler OCT and en face OCT functions, for simultaneous evaluation of perfusion and structure of the optic nerve head. We investigated the clinical usefulness of combined use of Doppler and en face Fourier-domain OCT functions of the AngioVue Fourier-domain OCT for discrimination of a disc hemorrhage and a disc hemorrhage–like atypical vessel structure located deep in the lamina cribrosa. We present our findings with AngioVue OCT on a disc hemorrhage and a spatially related retinal nerve fiber layer bundle ...

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    12. Comparison of the current and a new RTVue OCT software version for detection of ganglion cell complex changes due to cataract surgery

      Comparison of the current and a new RTVue OCT software version for detection of ganglion cell complex changes due to cataract surgery

      The purpose was to compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue OCT) for ganglion cell complex (GCC) and retinal nerve fibre layer thickness (RNFLT) changes after phacoemulsification in healthy cataract eyes, and to investigate whether version 6.12, in which image segmentation is improved, provides benefits over version 6.3 for RNFLT and GCC imaging via mild cataract. One eye of 22 consecutive healthy cataract patients were imaged before and 1 month after uncomplicated cataract surgery using RTVue-100 OCT software version 6.3. The images were analysed with ...

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    13. Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on Ganglion Cell Complex Segmentation in Various Forms of Age-related Macular Degeneration

      Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on Ganglion Cell Complex Segmentation in Various Forms of Age-related Macular Degeneration

      Purpose: Previously, we have shown that age-related macular degeneration (AMD) influences glaucoma classification with the ganglion cell complex (GCC) parameters of the RTVue-100 optical coherence tomograph (RTVue-OCT) in nonglaucomatous eyes. Now, we reevaluated the influence of AMD on GCC image segmentation and classification for glaucoma on the same eyes, using a new version of the software. Methods: GCC images of nonglaucomatous eyes [30 healthy, 19 with early/intermediate AMD, 16 with subfoveal choroidal neovascularization (CNV), and 19 after intravitreal antiangiogenic treatment of CNV, CNV-anti-VEGF] were reanalyzed with software versions 6.3 (the currently available version) and 6.12 (a version ...

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    14. Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome

      Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome

      PurposeTo describe the characteristic optical coherence tomography (OCT) findings of the iris in Cogan-Reese syndrome.MethodsA 63-year-old woman was referred for consultation due to diffuse pigmentation of the iris and elevated intraocular pressure (IOP) in the left eye. The clinical examination revealed Cogan-Reese syndrome with pedunculated iris outcroppings on the entire iris surface, and no peripheral anterior synechia. The right eye was normal with normal IOP.ResultsImaging the left iris with the CAM-L cornea lens adapter of the Optovue Fourier-domain OCT (RTVue-OCT) showed a folded iris surface, an increased total iris thickness, and an increased distance between the anterior and ...

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    15. Structure-Function Relationship Between the Octopus Perimeter Cluster Mean Sensitivity and Sector Retinal Nerve Fiber Layer Thickness Measured With the RTVue Optical Coherence Tomography and Scanning Laser Polarimetry

      Structure-Function Relationship Between the Octopus Perimeter Cluster Mean Sensitivity and Sector Retinal Nerve Fiber Layer Thickness Measured With the RTVue Optical Coherence Tomography and Scanning Laser Polarimetry

      Purpose: To determine structure-function relationship between each of 16 Octopus perimeter G2 program clusters and the corresponding 16 peripapillary sector retinal nerve fiber layer thickness (RNFLT) values measured with the RTVue-100 Fourier-domain optical coherence tomography (RTVue OCT) and scanning laser polarimetry with variable corneal compensation (GDx-VCC) and enhanced corneal compensation (GDx-ECC) corneal compensation. Methods: One eye of 110 white patients (15 healthy, 20 ocular hypertensive, and 75 glaucoma eyes) were investigated. The Akaike information criterion and the F test were used to identify the best fitting model. Results: Parabolic relationship with logarithmic cluster mean sensitivity and linear sector RNFLT values ...

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    16. Detection of Early Glaucomatous Progression With Different Parameters of the RTVue Optical Coherence Tomography

      Detection of Early Glaucomatous Progression With Different Parameters of the RTVue Optical Coherence Tomography

      Purpose: To investigate the ability of different parameters of the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) to detect early glaucomatous progression. Methods: One eye of 17 healthy and 51 perimetric glaucoma patients was imaged prospectively at 6-month intervals for 1.5 to 3 years. Progression was determined by Octopus normal G2 visual field progression criteria. Results: Ten of the 51 glaucoma eyes progressed based on visual field criteria. Median visual field mean defect change was -0.300 dB/y for the controls, -0.120 dB/y for all glaucoma eyes (P=0.461 vs. controls), and 1.231 dB/y ...

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    17. Influence of Age-related Macular Degeneration on Macular Thickness Measurement Made With Fourier-domain Optical Coherence Tomography

      Influence of Age-related Macular Degeneration on Macular Thickness Measurement Made With Fourier-domain Optical Coherence Tomography

      Purpose: To evaluate the influence of age-related macular degeneration (AMD) on macular thickness measurement made with Fourier-domain optical coherence tomography (RTVue-OCT) to detect glaucoma. Methods: One nonglaucomatous eye of 79 white persons was imaged. This comprised 25 healthy eyes, 19 eyes with early/intermediate AMD (geographic atrophy excluded), 16 eyes with subfoveal choroidal neovascularization (CNV), and 19 CNV eyes after intravitreal antiangiogenic treatment [CNV-antivascular endothelial growth factor (VEGF)]. Results: Compared with the age-matched controls, no difference in any nerve fiber layer and optic disc parameter was seen for any AMD group. No macular retinal segmentation error was detected in the ...

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    18. Comparison of diagnostic accuracy of the RTVue Fourier-domain OCT and the GDx-VCC/ECC polarimeter to detect glaucoma

      Comparison of diagnostic accuracy of the RTVue Fourier-domain OCT and the GDx-VCC/ECC polarimeter to detect glaucoma
      Purpose. To compare sensitivity and specificity of retinal nerve fiber layer thickness (RNFLT) measurements made using RTVue-100 Fourier-domain optical coherence tomography (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) or enhanced compensation (GDx-ECC). Methods. One eye of each of 177 consecutive patients was imaged. Healthy (n=50) and ocular hypertensive (n=28) eyes were defined as structurally undamaged, preperimetric (n=33) and perimetric (n=66) glaucoma eyes as diseased. Results. For average RNFLT, sensitivity was higher (?2 test, p=0.002) with RTVue-OCT (65.7%) than with GDx-VCC (49.5%). For superior and inferior RNFLT, sensitivity was similar with all ...
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    19. Accuracy of the RTVue-100 Fourier-domain optical coherence tomograph in an optic neuropathy screening trial

      Accuracy of the RTVue-100 Fourier-domain optical coherence tomograph in an optic neuropathy screening trial
      The aim of this study was to evaluate the usefulness of the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-100 OCT) in screening for glaucoma and non-arteritic anterior ischemic optic neuropathy (NA-AION). In a non-population-based pre-publicised trial, self-recruited Caucasian participants were screened for glaucoma and NA-AION using the RTVue-100 OCT, and also by independent clinical examination. For the RTVue-100 OCT measurements, the optic nerve head (ONH) scan and the macular ganglion cell complex (GCC) scan were applied. Subjects with possible optic neuropathy (as indicated by any of the scans and/or by the clinical examination) underwent a detailed clinical investigation to verify ...
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    20. Reproducibility of Retinal Nerve Fiber Layer and Macular Thickness Measurement with the RTVue-100 Optical Coherence Tomography

      Purpose: To evaluate the reproducibility of peripapillary retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex (GCC) measurements made with the RTVue-100 Fourier-domain optical coherence tomography (OCT) device (Optovue, Inc., Fremont, CA) and to determine the influence of 4 factors: pupil dilation, subject age, experience in imaging examinations, and glaucoma severity.Design: Prospective study for evaluation of a diagnostic test.Participants: Thirty-seven hospital-based participants (14 normal and ocular hypertensive subjects, 11 patients with moderate and 12 with severe glaucoma), all experienced in imaging examinations, and 40 consecutive screening trial participants lacking such experience.Methods: One eye of all participants ...
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    1-20 of 20
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    Accuracy of the RTVue-100 Fourier-domain optical coherence tomograph in an optic neuropathy screening trial Comparison of diagnostic accuracy of the RTVue Fourier-domain OCT and the GDx-VCC/ECC polarimeter to detect glaucoma Influence of Age-related Macular Degeneration on Macular Thickness Measurement Made With Fourier-domain Optical Coherence Tomography Detection of Early Glaucomatous Progression With Different Parameters of the RTVue Optical Coherence Tomography Structure-Function Relationship Between the Octopus Perimeter Cluster Mean Sensitivity and Sector Retinal Nerve Fiber Layer Thickness Measured With the RTVue Optical Coherence Tomography and Scanning Laser Polarimetry Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome Influence of a New Software Version of the RTVue-100 Optical Coherence Tomograph on Ganglion Cell Complex Segmentation in Various Forms of Age-related Macular Degeneration Evaluation of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex Progression Rates in Healthy, Ocular Hypertensive, and Glaucoma Eyes With the Avanti RTVue-XR Optical Coherence Tomograph Based on 5-Year Follow-up Influence of Large Intraocular Pressure Reduction on Peripapillary OCT Vessel Density in Ocular Hypertensive and Glaucoma Eyes Chalcogenide-glass polarization-maintaining photonic crystal fiber for mid-infrared supercontinuum generation Supervised machine learning based multi-task artificial intelligence classification of retinopathies OCT-Detected Optic Nerve Head Neural Canal Direction, Obliqueness and Minimum Cross-Sectional Area in Healthy Eyes