1. Articles from Michael K. K. Leung

    1-4 of 4
    1. Optimized speckle variance OCT imaging of microvasculature

      Optimized speckle variance OCT imaging of microvasculature
      We optimize speckle variance optical coherence tomography (svOCT) imaging of microvasculature in high and low bulk tissue motion scenarios. To achieve a significant level of image contrast, frame rates must be optimized such that tissue displacement between frames is less than the beam radius. We demonstrate that higher accuracy estimates of speckle variance can enhance the detection of capillaries. These findings are illustrated in vivo by imaging the dorsal window chamber model (low bulk motion). We also show svOCT imaging of the nonstabilized finger (high bulk motion), using optimized imaging parameters, demonstrating better vessel detection than Doppler OCT.
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    2. Simultaneous 6-channel optical coherence tomography using a high-power telescope-less polygon-based swept laser in dual amplifier configuration

      Simultaneous 6-channel optical coherence tomography using a high-power telescope-less polygon-based swept laser in dual amplifier configuration
      Multichannel optical coherence tomography (MOCT) imaging is demonstrated using a high-power wavelength-swept laser source. The main benefit of MOCT is faster image acquisition rates without a corresponding increase in the laser tuning speed. The wavelength-swept laser was constructed using a compact telescope-less polygon-based filter in Littman arrangement. High output power, necessary for MOCT, was achieved by incorporating two serial semiconductor optical amplifiers in a ring laser cavity in Fourier domain mode-locked configuration. The laser has a measured wavelength tuning range of 111 nm centered at 1329 nm, coherence length of 5.5 mm, and total average output power of 131 ...
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    3. Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration

      Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration
      We demonstrate the potential of a forward-looking Doppler optical coherence tomography (OCT) probe for color flow imaging in several commonly seen narrowed artery morphologies. As a proof of concept, we present imaging results of a surgically exposed thrombotic occlusion model that was imaged superficially to demonstrate that Doppler OCT can identify flow within the recanalization channels of a blocked artery. We present Doppler OCT images in which the flow is nearly antiparallel to the imaging direction. These images are acquired using a flexible 2.2-mm-diam catheter that used electrostatic actuation to scan up to 30 deg ahead of the distal ...
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    4. In vivo endoscopic multi-beam optical coherence tomography

      In vivo endoscopic multi-beam optical coherence tomography
      multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 ┬Ám full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation ...
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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) University of Toronto
    2. (3 articles) Ryerson University
    3. (2 articles) Ontario Cancer Institute
    4. (2 articles) Sunnybrook Health Sciences Centre
    5. (1 articles) York University
    6. (1 articles) Massachusetts General Hospital
    7. (1 articles) Harvard University
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    In vivo endoscopic multi-beam optical coherence tomography Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration Simultaneous 6-channel optical coherence tomography using a high-power telescope-less polygon-based swept laser in dual amplifier configuration Optimized speckle variance OCT imaging of microvasculature Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma OCT-angiography follow-up of choroidal neovascularization treated with treat- and- extend aflibercept regimen to avoid over-treatment A Review of Spectroscopic and Non-Spectroscopic Techniques for Diagnosing Breast Cancer Collaboration Between Seno Medical and Cogmedix Drives GOLDEN Results for Innovative Medical Breast Imaging System Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness Changes of blood flow in macular zone of patients with diabetic retinopathy at different stages evaluated by optical coherence tomography angiography Very late stent thrombosis lacking findings of the typical causes on optical coherence tomography in a patient with SARS-CoV-2