1. Articles from Anthony Lee

    1-4 of 4
    1. Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

      Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

      Significance: Diagnosis of suspicious lung nodules requires precise collection of relevant biopsies for histopathological analysis. Using optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in parts of the lung inaccessible to larger imaging methods may allow for reducing complications related to the alternative of computed tomography-guided biopsy. Aim: Feasibility of OCT-AFI combined with a commercially available lung biopsy needle was demonstrated for visualization of needle puncture sites in airways with diameters as small as 1.9 mm. Approach: A miniaturized OCT-AFI imaging stylet was developed to be inserted through an 18G biopsy needle. We present design considerations ...

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    2. Submillimeter diameter rotary-pullback fiber-optic endoscope for narrowband red-green-blue reflectance, optical coherence tomography, and autofluorescence in vivo imaging

      Submillimeter diameter rotary-pullback fiber-optic endoscope for narrowband red-green-blue reflectance, optical coherence tomography, and autofluorescence in vivo imaging

      A fiber-based endoscopic imaging system combining narrowband red-green-blue (RGB) reflectance with optical coherence tomography (OCT) and autofluorescence imaging (AFI) has been developed. The system uses a submillimeter diameter rotary-pullback double-clad fiber imaging catheter for sample illumination and detection. The imaging capabilities of each modality are presented and demonstrated with images of a multicolored card, fingerprints, and tongue mucosa. Broadband imaging, which was done to compare with narrowband sources, revealed better contrast but worse color consistency compared with narrowband RGB reflectance. The measured resolution of the endoscopic system is 25  μm in both the rotary direction and the pullback direction. OCT ...

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    3. Systems For Optical Imaging Of Biological Tissues

      Systems For Optical Imaging Of Biological Tissues

      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment provides a system adapted to provide co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging. AF excitation light is introduced and collected AF light is extracted at a fiber optic rotary joint (FORJ ...

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    4. Optical coherence tomography imaging of preneoplastic lung lesion

      Although autofluorescence bronchoscopy improves the detection rate of high grade dysplasia and carcinoma in-situ compares to white-light examination, the natural history of preneoplastic bronchial lesions is still poorly understood because the biopsy procedure for histological confirmation can mechanically remove these small lesions. The lack of accurate information regarding the spontaneous progression and regression rates of preneoplastic lesions make if difficult to assess the effect of chemoprevention agents. It is therefore important to develop non-biopsy methods that can characterize preneoplastic lesions in the bronchial epithelium. Optical coherence tomography (OCT) is an optical imaging method that can visualize cellular and extra-cellular structures ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) British Columbia Cancer Agency
    2. (4 articles) Pierre M. Lane
    3. (3 articles) Stephen Lam
    4. (1 articles) Simon Fraser University
    5. (1 articles) Ryerson University
    6. (1 articles) University of British Columbia
    7. (1 articles) Hamid Pahlevaninezhad
    8. (1 articles) Victor X. D. Yang
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    Systems For Optical Imaging Of Biological Tissues Submillimeter diameter rotary-pullback fiber-optic endoscope for narrowband red-green-blue reflectance, optical coherence tomography, and autofluorescence in vivo imaging Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement Systems and methods for reflectance-based projection-resolved optical coherence tomography angiography Health collaborations forged at CIIE begin to bear fruit Method for determining the topography of the cornea of an eye Optical measurement system using multicore optical fiber Fiber optic rotary joints and methods of using and manufacturing same High performance OCTA enabled by combining features of shape, intensity, and complex decorrelation A Novel 3D Segmentation Approach for Extracting Retinal Layers from Optical Coherence Tomography Images Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography Albumin‐PEG‐Based Biomaterial for Laser‐Tissue Soldering and Its Real‐Time Monitoring With Swept‐Source Optical Coherence Tomography