1. Articles from Pierre Lane

    1-24 of 32 1 2 »
    1. Post-Doctoral Fellowship at British Columbia Cancer Research Institute

      Post-Doctoral Fellowship at British Columbia Cancer Research Institute

      POST-DOCTORAL FELLOWSHIP The Optical Cancer Imaging Lab ( OCIL ) at the BC Cancer Research Institute ( BCCRI ) in Vancouver, Canada, has an opening for a Post-Doctoral Fellow. The OCIL develops and validates non-invasive high-resolution optical tools for the early detection and management of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo , ex vivo , and in silica evaluation of tissues from sites including lung, cervix, oral cavity, skin and colon. Further information is available online ( http://www.biophotonics.bccrc.ca). We are seeking a qualified individual to lead a funded research project to develop image-guided biopsy ...

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    2. software development TO OPTIMIZE THE minimal detectable difference IN huMAN AIRWAY IMAGES CAPTURED USING optical coherence tomography

      software development TO OPTIMIZE THE minimal detectable difference IN huMAN AIRWAY IMAGES CAPTURED USING optical coherence tomography

      Optical coherence tomography (OCT) is an imaging methodology that can be used to assess human airways. OCT avoids the harmful effects of ionizing radiation and has a high spatial resolution making it well suited for imaging the structure of small airways. Analysis of OCT airway images has typically been performed manually by tracing the airway with a relatively high coefficient of variation. The purpose of this study was to develop an analysis tool to reduce the inter- and intra-observer reproducibility of OCT and improve the ability to detect differences in airways. OCT images from healthy, young human volunteers were used ...

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    3. Airway luminal area and the resistive work of breathing during exercise in healthy young females and males

      Airway luminal area and the resistive work of breathing during exercise in healthy young females and males

      We examined the relationship between the work of breathing (W b ) during exercise and in vivo measures of airway size in healthy females and males. We hypothesized that sex-differences in airway luminal area (Ai) would explain the larger resistive W b during exercise in females. Healthy participants (n=11 females and n=11 males; 19-30 y) completed a cycle exercise test to exhaustion where W b was assessed using an esophageal balloon catheter. On a separate day, participants underwent a bronchoscopy procedure for optical coherence tomography measures of airways in the left (n=3) and right (n=4) lung. In ...

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    4. Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction

      Small airway dilation measured by endoscopic optical coherence tomography correlates with chronic lung allograft dysfunction

      Significance: Chronic lung allograft dysfunction (CLAD) is the leading cause of death in transplant patients who survive past the first year post-transplant. Current diagnosis is based on sustained decline in lung function; there is a need for tools that can identify CLAD onset. Aim: Endoscopic optical coherence tomography (OCT) can visualize structural changes in the small airways, which are of interest in CLAD progression. We aim to identify OCT features in the small airways of lung allografts that correlate with CLAD status. Approach: Imaging was conducted with an endoscopic rotary pullback OCT catheter during routine bronchoscopy procedures (n = 54), collecting ...

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    5. Higher-Order Core-Like Modes in Double-Clad Fiber Contribute to Multipath Artifacts in Optical Coherence Tomography

      Higher-Order Core-Like Modes in Double-Clad Fiber Contribute to Multipath Artifacts in Optical Coherence Tomography

      Double-clad fiber (DCF) has enabled the combination of endoscopic optical coherence tomography (OCT) with secondary optical modalities. While DCF offers an additional optical channel, it is widely understood that its use reduces the quality of OCT owing to the introduction of multipath artifacts. We show here that an unexpected higher-order mode (HOM) with its energy confined to the DCF core can contribute to these artifacts. The existence of this HOM is confirmed using the spatially and spectrally (S2) resolved imaging method. The group delay difference of the HOM is shown to be consistent with the delay of the diffuse ghost ...

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    6. Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise

      Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy and physiological function during dynamic exercise

      Airway luminal area (A i ) influences respiratory mechanics during dynamic exercise; however, previous studies have investigated the relationship between airway anatomy and physiological function in different groups of individuals. The purpose of this study was to determine the effect of A i on respiratory mechanics by making in vivo measures of airway dimensions and work of breathing (Wb) in the same individuals. Healthy participants (3F/2M; 23-45 years) completed a cycle exercise test to exhaustion. During exercise, Wb was assessed using an esophageal balloon catheter, while simultaneously assessing minute ventilation ( ˙ V E ). On a separate day, subjects underwent a bronchoscopy ...

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    7. Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

      Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement

      Significance: Diagnosis of suspicious lung nodules requires precise collection of relevant biopsies for histopathological analysis. Using optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in parts of the lung inaccessible to larger imaging methods may allow for reducing complications related to the alternative of computed tomography-guided biopsy. Aim: Feasibility of OCT-AFI combined with a commercially available lung biopsy needle was demonstrated for visualization of needle puncture sites in airways with diameters as small as 1.9 mm. Approach: A miniaturized OCT-AFI imaging stylet was developed to be inserted through an 18G biopsy needle. We present design considerations ...

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    8. Small airway dilation visualized by optical coherence tomography (OCT) correlates with the diagnosis of chronic lung allograft dysfunction (CLAD)

      Small airway dilation visualized by optical coherence tomography (OCT) correlates with the diagnosis of chronic lung allograft dysfunction (CLAD)

      Background: Small airways and the surrounding tissue of the lung allograft are often affected by pathological processes including acute cellular rejection (ACR), infections and different phenotypes of CLAD. OCT with superior resolution but shallow penetration, allows the visualization of these structures in contrast to routine radiographic imaging. Methods: We studied 54 lung transplant (LTx) recipients with OCT imaging during surveillance (n=36) or event (n=19) bronchoscopies. Volumetric images of 3 segmental airways were collected from each patient. OCT features were scored by 4 raters blinded to the clinical status of LTx recipients. Pearson correlation coefficients (R) were used to ...

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    9. Submillimeter diameter rotary-pullback fiber-optic endoscope for narrowband red-green-blue reflectance, optical coherence tomography, and autofluorescence in vivo imaging

      Submillimeter diameter rotary-pullback fiber-optic endoscope for narrowband red-green-blue reflectance, optical coherence tomography, and autofluorescence in vivo imaging

      A fiber-based endoscopic imaging system combining narrowband red-green-blue (RGB) reflectance with optical coherence tomography (OCT) and autofluorescence imaging (AFI) has been developed. The system uses a submillimeter diameter rotary-pullback double-clad fiber imaging catheter for sample illumination and detection. The imaging capabilities of each modality are presented and demonstrated with images of a multicolored card, fingerprints, and tongue mucosa. Broadband imaging, which was done to compare with narrowband sources, revealed better contrast but worse color consistency compared with narrowband RGB reflectance. The measured resolution of the endoscopic system is 25  μm in both the rotary direction and the pullback direction. OCT ...

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    10. Systems for optical imaging of biological tissues

      Systems for optical imaging of biological tissues

      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment provides a system adapted to provide co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging. AF excitation light is introduced and collected AF light is extracted at a fiber optic rotary joint (FORJ ...

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    11. Depth-multiplexed optical coherence tomography dual-beam manually-actuated distortion-corrected imaging (DMDI) with a micromotor catheter

      Depth-multiplexed optical coherence tomography dual-beam manually-actuated distortion-corrected imaging (DMDI) with a micromotor catheter

      We present a new micromotor catheter implementation of dual-beam manually-actuated distortion-corrected imaging (DMDI). The new catheter called a depth-multiplexed dual-beam micromotor catheter, or mDBMC, maintains the primary advantage of unlimited field-of-view distortion-corrected imaging along the catheter axis. The mDBMC uses a polarization beam splitter and cube mirror to create two beams that scan circularly with approximately constant separation at the catheter surface. This arrangement also multiplexes both imaging channels into a single optical coherence tomography channel by offsetting them in depth, requiring half the data bandwidth compared to previous DMDI demonstrations that used two parallel image acquisition systems. Furthermore, the ...

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    12. Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer

      Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer

      We recently demonstrated a new two-dimensional imaging paradigm called dual-beam manually actuated distortion-corrected imaging (DMDI). This technique uses a single mechanical scanner and two spatially separated beams to determine relative sample velocity and simultaneously corrects image distortions due to manual actuation. DMDI was first demonstrated using a rotating dual-beam micromotor catheter. Here, we present a new implementation of DMDI using a single axis galvanometer to scan a pair of beams in approximately parallel lines onto a sample. Furthermore, we present a method for automated distortion correction based on frame co-registration between images acquired by the two beams. Distortion correction is ...

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    13. Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration

      Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration

      We present a method for the correction of motion artifacts present in two- and three-dimensional in vivoendoscopic images produced by rotary-pullback catheters. This method can correct for cardiac/breathing-based motion artifacts and catheter-based motion artifacts such as nonuniform rotational distortion (NURD). This method assumes that en face tissue imaging contains slowly varying structures that are roughly parallel to the pullback axis. The method reduces motion artifacts using a dynamic time warping solution through a cost matrix that measures similarities between adjacent frames in en face images. We optimize and demonstrate the suitability of this method using a real and ...

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    14. PhD Studentship at British Columbia Cancer Agency

      PhD Studentship at British Columbia Cancer Agency

      The Optical Cancer Imaging Lab (OCIL) at the British Columbia Cancer Agency (BCCA) in Vancouver, Canada, has an opening for a PhD student (September 2018 start). The OCIL develops and validates non-invasive high-resolution optical tools for the early detection and management of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo , ex vivo , and in silica evaluation of tissues from different organ sites including lung, cervix, oral cavity, skin and colon. Further information is available online ( http://www.biophotonics.bccrc.ca ). We are seeking a qualified individual to work on a mutually beneficial project ...

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    15. Post-Doctoral Fellowship at BC Cancer Agency

      Post-Doctoral Fellowship at BC Cancer Agency

      The Optical Cancer Imaging Lab (OCIL) at the British Columbia Cancer Agency (BCCA) in Vancouver, Canada, has an opening for a Post-Doctoral Fellow (January 2018 start). The OCIL develops and validates non-invasive high-resolution optical tools for the early detection and management of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo , ex vivo , and in silica evaluation of tissues from different organ sites including lung, cervix, oral cavity, skin and colon. Further information is available online ( http://www.biophotonics.bccrc.ca ). We are seeking a qualified individual to lead mutually beneficial projects related to ...

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    16. Dual-beam manually-actuated distortion-corrected imaging (DMDI) with micromotor catheters

      Dual-beam manually-actuated distortion-corrected imaging (DMDI) with micromotor catheters

      e present a new paradigm for performing two-dimensional scanning called dual-beam manually-actuated distortion-corrected imaging (DMDI). DMDI operates by imaging the same object with two spatially-separated beams that are being mechanically scanned rapidly in one dimension with slower manual actuation along a second dimension. Registration of common features between the two imaging channels allows remapping of the images to correct for distortions due to manual actuation. We demonstrate DMDI using a 4.7 mm OD rotationally scanning dual-beam micromotor catheter (DBMC). The DBMC requires a simple, one-time calibration of the beam paths by imaging a patterned phantom. DMDI allows for distortion ...

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    17. PhD Studentship in The Optical Cancer Imaging Lab at the British Columbia Cancer Agency

      PhD Studentship in The Optical Cancer Imaging Lab at the British Columbia Cancer Agency

      The Optical Cancer Imaging Lab (OCIL) at the British Columbia Cancer Agency (BCCA) in Vancouver, Canada, has an opening for a PhD student (September 2017 start). The OCIL develops and validates non-invasive high-resolution optical tools for the early detection and management of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo , ex vivo , and in silica evaluation of tissues from different organ sites including lung, cervix, oral cavity, skin and colon. Further information is available online ( www.biophotonics.bccrc.ca ). The successful candidate will receive his/her degree from Simon Fraser University ( www.sfu ...

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    18. Reproducibility of optical coherence tomography airway imaging

      Reproducibility of optical coherence tomography airway imaging

      Optical coherence tomography (OCT) is a promising imaging technique to evaluate small airway remodeling. However, the short-term insertion-reinsertion reproducibility of OCT for evaluating the same bronchial pathway has yet to be established. We evaluated 74 OCT data sets from 38 current or former smokers twice within a single imaging session. Although the overall insertion-reinsertion airway wall thickness (WT) measurement coefficient of variation (CV) was moderate at 12%, much of the variability between repeat imaging was attributed to the observer; CV for repeated measurements of the same airway (intra-observer CV) was 9%. Therefore, reproducibility may be improved by introduction of automated ...

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    19. Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual presentation for the rapid identification of suspicious airway sites, while co-registered OCT provides detailed structural information to assess the airway morphology. We demonstrate the ability of AFI to visualize vascular ...

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    20. Systems For Optical Imaging Of Biological Tissues

      Systems For Optical Imaging Of Biological Tissues

      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment provides a system adapted to provide co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging. AF excitation light is introduced and collected AF light is extracted at a fiber optic rotary joint (FORJ ...

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    21. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Bronchial thermoplasty (BT) is a novel, nonpharmacological procedure for treatment of severe asthma. Recently, the Asthma Intervention Research 2 clinical trial demonstrated asthmatics had fewer hospitalisations following BT, which persisted 5 years after therapy [1]. However, it is well recognised that asthma is a heterogeneous disease with distinct asthma phenotypes and, not surprisingly, not all asthmatics in that trial benefited from BT [2].

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    22. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Polarization Sensitive Optical Coherence Tomography (PSOCT) is a functional extension of Optical Coherence Tomography (OCT) that is sensitive to well-structured, birefringent tissue such as scars, smooth muscle and cartilage. In this work, we present a novel completely fiber based swept source PSOCT system using a fiber-optic rotary pullback catheter. This PSOCT implementation uses only passive optical components and requires no calibration while adding minimal additional cost to a standard structural OCT imaging system. Due to its complete fiber construction, the system can be made compact and robust, while the fiber-optic catheter allows access to most endoscopic imaging sites. The 1 ...

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    23. Fiber-Based Polarization Diversity Detection for Polarization-Sensitive Optical Coherence Tomography

      Fiber-Based Polarization Diversity Detection for  Polarization-Sensitive Optical Coherence Tomography

      We present a new fiber-based polarization diversity detection (PDD) scheme for polarization sensitive optical coherence tomography (PSOCT). This implementation uses a new custom miniaturized polarization-maintaining fiber coupler with single mode (SM) fiber inputs and polarization maintaining (PM) fiber outputs. The SM fiber inputs obviate matching the optical lengths of the two orthogonal OCT polarization channels prior to interference while the PM fiber outputs ensure defined orthogonal axes after interference. Advantages of this detection scheme over those with bulk optics PDD include lower cost, easier miniaturization, and more relaxed alignment and handling issues. We incorporate this PDD scheme into a galvanometer-scanned ...

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    24. A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 µm diameter catheter ‒ consisting of a rotating lens assembly, double-clad fiber (DCF), and torque cable in a stationary plastic tube ‒ was fabricated to allow AF/OCT imaging of small airways ...

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    1-24 of 32 1 2 »
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    Postdoctoral Fellowship in the Integrative Oncolog Department at The Integrative Oncology Department at the British Columbia Cancer Agency Research Assistant OCT Engineer at The Integrative Oncology Imaging Unit at the British Columbia Cancer Fiber-optic polarization diversity detection for rotary probe optical coherence tomography Validation of Airway Wall Measurements by Optical Coherence Tomography in Porcine Airways A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography PhD Studentship in The Optical Cancer Imaging Lab at the British Columbia Cancer Agency Post-Doctoral Fellowship at BC Cancer Agency PhD Studentship at British Columbia Cancer Agency Post-Doctoral Fellowship at British Columbia Cancer Research Institute New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application Short-sighted woman assumes debilitating headaches mean she needs new glasses but discovers she has multiple sclerosis Shedding light on the impact of microplastics on lentil seedling growth